Reference of 875-35-4, Adding some certain compound to certain chemical reactions, such as: 875-35-4, name is 2,6-Dichloro-4-methylnicotinonitrile,molecular formula is C7H4Cl2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 875-35-4.
Method 2 Concentrated nitric acid (14 mL) was added to cooled (0 C.) concentrated sulfuric acid (43 mL) maintaining the internal temperature below 10 C. After addition, the acid mixture was heated to 70 C. and commercially available (Avocado) 2,6-dichloro-4-methylnicotinonitrile (20.0 g, 107 mmol) was added. The temperature was raised until the internal temperature of the reaction reached 105 C. At this point the heating was stopped and after 2 h, TLC analysis revealed that the reaction was complete. The reaction mixture was cooled to room temperature, and slowly added to ice (100 g) with strong agitation. The solid was filtered and washed with cold water (10 mL). The solid was dissolved in EtOAc (100 mL) and the solution was dried over Na2SO4 and concentrated to give 2,6-dichloro-4-methyl-nicotinic acid (21.0 g, 96%) as a white solid: Rf=0.20 (1:1 EtOAc:Hex).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 875-35-4, 2,6-Dichloro-4-methylnicotinonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Wang, Yamin; Bullock, William H.; Chen, Libing; US6677352; (2004); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem