Category: 87674-21-3

Adding a certain compound to certain chemical reactions, such as: 87674-21-3, 1-(3-Fluoropyridin-4-yl)ethanone, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H6FNO, blongs to pyridine-derivatives compound. Computed Properties of C7H6FNO

To a stirred solution of 3-fluoro-4-acetylpyridine (5.3 g, 38.1 mmol) in glacial acetic acid (14 mL) and 48% hydrobromic acid (5.3 mL), bromine (2 mL, 38 mmol) in glacial acetic acid (5.3 mL) was added slowly and dropwise. After addition, the solution was stirred at 60 C. for 2.5 h then it was cooled down and ethylacetate (70 mL) was added. After 30′ stirring the mixture was filtered and the solid was washed thoroughly with ethylacetate and dried. The title compound was obtained in 82% yield (9.4 g). 1H NMR (DMSO-d6/400 MHz) delta ppm 4.88 (s, 2 H) 7.83 (dd, 1 H) 8.62 (dd, 1 H) 8.81 (d, 1 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,87674-21-3, 1-(3-Fluoropyridin-4-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Patent; Pharmacia Italia S.p.A.; US2007/142414; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 87674-21-3, 1-(3-Fluoropyridin-4-yl)ethanone, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H6FNO, blongs to pyridine-derivatives compound. Computed Properties of C7H6FNO

To a stirred solution of 3-fluoro-4-acetylpyridine (5.3 g, 38.1 mmol) in glacial acetic acid (14 mL) and 48% hydrobromic acid (5.3 mL), bromine (2 mL, 38 mmol) in glacial acetic acid (5.3 mL) was added slowly and dropwise. After addition, the solution was stirred at 60 C. for 2.5 h then it was cooled down and ethylacetate (70 mL) was added. After 30′ stirring the mixture was filtered and the solid was washed thoroughly with ethylacetate and dried. The title compound was obtained in 82% yield (9.4 g). 1H NMR (DMSO-d6/400 MHz) delta ppm 4.88 (s, 2 H) 7.83 (dd, 1 H) 8.62 (dd, 1 H) 8.81 (d, 1 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,87674-21-3, 1-(3-Fluoropyridin-4-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Patent; Pharmacia Italia S.p.A.; US2007/142414; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 87674-21-3, Adding some certain compound to certain chemical reactions, such as: 87674-21-3, name is 1-(3-Fluoropyridin-4-yl)ethanone,molecular formula is C7H6FNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 87674-21-3.

[0378] 3-Fluoro-l-(2-bromo-4-pyridinyl)ethanone Hydrobromide (169). l-(3- Fluoro-4-pyridinyl)ethanone (168) (880 mg, 6.33 mmol) was dissolved in glacial acetic acid (20 mL) and treated with bromine (0.36 mL, 7.0 mmol) followed by HBr/AcOH (30% w/v, 1.4 mL, 7.0 mmol) at 5-10 0C. The reaction mixture was stirred at 20 0C for 3 h, it was then diluted with Et2O (100 mL) and the precipitate was filtered off, washed with Et2O and dried under high vacuum to afford the crude bromoketone 169 (1.65 g) as a pale yellow solid that was used without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 87674-21-3, 1-(3-Fluoropyridin-4-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; AUCKLAND UNISERVICES LIMITED; WO2009/114552; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 87674-21-3, 1-(3-Fluoropyridin-4-yl)ethanone, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 87674-21-3, blongs to pyridine-derivatives compound. HPLC of Formula: C7H6FNO

To a stirred solution of 3-fluoro-4-acetylpyridine (5.3 g, 38.1 mmol) in glacial acetic acid (14 mL) and 48% hydrobromic acid (5.3 mL), bromine (2 mL, 38 mmol) in glacial acetic acid (5.3 mL) was added slowly and dropwise. After addition, the solution was stirred at 60 C. for 2.5 hour. This solution was cooled down and ethylacetate (70 mL) was added. After 30 minutes of stirring, the mixture was filtered and the solid was washed thoroughly with ethylacetate and dried. The title compound was obtained in 82% yield (9.4 g). 1H NMR (DMSO-d6/400 MHz) delta ppm 4.88 (s, 2 H) 7.83 (dd, 1 H) 8.62 (dd, 1 H) 8.81 (d, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,87674-21-3, its application will become more common.

Reference:
Patent; Pharmacia Italia S.p.A.; US2007/142415; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 87674-21-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.87674-21-3, name is 1-(3-Fluoropyridin-4-yl)ethanone, molecular formula is C7H6FNO, molecular weight is 139.13, as common compound, the synthetic route is as follows.

To a stirred solution of 3-FLUORO-4-ACETYLPYRIDINE (5.3 g, 38.1 MMOL) in glacial acetic acid (14 mL) and 48% HYDROBROMIC acid (5.3 mL), bromine (2 mL, 38 MMOL) in glacial acetic acid (5.3 mL) was added slowly and dropwise. After addition, the solution was stirred at 60C for 2.5 h then it was cooled down and ethylacetate (70 mL) was added. After 30’stirring the mixture was filtered and the solid was washed thoroughly with ethylacetate and dried. The title compound was obtaind in 82% yield (9.4 g). ‘H NMR (DMSO-D6/300 MHz) 5 ppm 4.88 (s, 2 H) 7.83 (dd, 1 H) 8.62 (DD, 1 H) 8.81 (d, 1 H).

The chemical industry reduces the impact on the environment during synthesis 87674-21-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; PHARMACIA ITALIA S.P.A.; WO2005/13986; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 87674-21-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.87674-21-3, name is 1-(3-Fluoropyridin-4-yl)ethanone, molecular formula is C7H6FNO, molecular weight is 139.13, as common compound, the synthetic route is as follows.

To a stirred solution of 3-FLUORO-4-ACETYLPYRIDINE (5.3 g, 38.1 MMOL) in glacial acetic acid (14 mL) and 48% HYDROBROMIC acid (5.3 mL), bromine (2 mL, 38 MMOL) in glacial acetic acid (5.3 mL) was added slowly and dropwise. After addition, the solution was stirred at 60C for 2.5 h then it was cooled down and ethylacetate (70 mL) was added. After 30’stirring the mixture was filtered and the solid was washed thoroughly with ethylacetate and dried. The title compound was obtaind in 82% yield (9.4 g). ‘H NMR (DMSO-D6/300 MHz) 5 ppm 4.88 (s, 2 H) 7.83 (dd, 1 H) 8.62 (DD, 1 H) 8.81 (d, 1 H).

The chemical industry reduces the impact on the environment during synthesis 87674-21-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; PHARMACIA ITALIA S.P.A.; WO2005/13986; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem