Category: 876919-08-3

Bregman, Howard; Chakka, Nagasree; Guzman-Perez, Angel; Gunaydin, Hakan; Gu, Yan; Huang, Xin; Berry, Virginia; Liu, Jingzhou; Teffera, Yohannes; Huang, Liyue; Egge, Bryan; Mullady, Erin L.; Schneider, Steve; Andrews, Paul S.; Mishra, Ankita; Newcomb, John; Serafino, Randy; Strathdee, Craig A.; Turci, Susan M.; Wilson, Cindy; DiMauro, Erin F. published the artcile< Discovery of Novel, Induced-Pocket Binding Oxazolidinones as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors>, Recommanded Product: Methyl 3-fluoroisonicotinate, the main research area is preparation SAR oxazolidinone orally bioavailable tankyrase inhibitor mol modeling.

Tankyrase (TNKS) is a poly-ADP-ribosylating protein (PARP) whose activity suppresses cellular axin protein levels and elevates β-catenin concentrations, resulting in increased oncogene expression. The inhibition of tankyrase (TNKS1 and 2) may reduce the levels of β-catenin-mediated transcription and inhibit tumorigenesis. Compound I is a previously described moderately potent tankyrase inhibitor that suffers from poor pharmacokinetic properties. Herein, we describe the utilization of structure-based design and mol. modeling toward novel, potent, and selective tankyrase inhibitors with improved pharmacokinetic properties (II, III).

Journal of Medicinal Chemistry published new progress about Axins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 876919-08-3 belongs to class pyridine-derivatives, and the molecular formula is C7H6FNO2, Recommanded Product: Methyl 3-fluoroisonicotinate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wagener, Tobias; Heusler, Arne; Nairoukh, Zackaria; Bergander, Klaus; Daniliuc, Constantin G.; Glorius, Frank published the artcile< Accessing (Multi)Fluorinated Piperidines Using Heterogeneous Hydrogenation>, Category: pyridine-derivatives, the main research area is fluoropiperidine diastereoselective preparation; palladium heterogeneous catalyst stereoselective hydrogenation fluoropyridine.

Fluorinated piperidines are desirable motifs for pharmaceutical and agrochem. research. Nevertheless, general synthetic access remains out of reach. Herein, we describe a simple and robust cis-selective hydrogenation of abundant and cheap fluoropyridines to yield a broad scope of (multi)fluorinated piperidines. This protocol enables the chemoselective reduction of fluoropyridines while tolerating other (hetero)aromatic systems using a com. available heterogeneous catalyst. Fluorinated derivatives of important drug compounds are prepared, and a straightforward strategy for the synthesis of enantioenriched fluorinated piperidines is disclosed.

ACS Catalysis published new progress about Aryl fluorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (fluoropyridines). 876919-08-3 belongs to class pyridine-derivatives, and the molecular formula is C7H6FNO2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wagener, Tobias; Heusler, Arne; Nairoukh, Zackaria; Bergander, Klaus; Daniliuc, Constantin G.; Glorius, Frank published the artcile< Accessing (Multi)Fluorinated Piperidines Using Heterogeneous Hydrogenation>, Category: pyridine-derivatives, the main research area is fluoropiperidine diastereoselective preparation; palladium heterogeneous catalyst stereoselective hydrogenation fluoropyridine.

Fluorinated piperidines are desirable motifs for pharmaceutical and agrochem. research. Nevertheless, general synthetic access remains out of reach. Herein, we describe a simple and robust cis-selective hydrogenation of abundant and cheap fluoropyridines to yield a broad scope of (multi)fluorinated piperidines. This protocol enables the chemoselective reduction of fluoropyridines while tolerating other (hetero)aromatic systems using a com. available heterogeneous catalyst. Fluorinated derivatives of important drug compounds are prepared, and a straightforward strategy for the synthesis of enantioenriched fluorinated piperidines is disclosed.

ACS Catalysis published new progress about Aryl fluorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (fluoropyridines). 876919-08-3 belongs to class pyridine-derivatives, and the molecular formula is C7H6FNO2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nacsa, Eric D.; MacMillan, David W. C. published the artcile< Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols>, Formula: C7H6FNO2, the main research area is chiral aldehyde enantioselective preparation; aldehyde alc enantioselective benzylation photoredox organocatalyst photocatalyst.

Nature routinely engages alcs. as leaving groups, as DNA biosynthesis relies on the removal of water from ribonucleoside diphosphates by a radical-mediated “”spin-center shift”” (SCS) mechanism. Alcs., however, remain underused as alkylating agents in synthetic chem. due to their low reactivity in two-electron pathways. We report herein an enantioselective α-benzylation of aldehydes using alcs. as alkylating agents based on the mechanistic principle of spin-center shift. This strategy harnesses the dual activation modes of photoredox and organocatalysis, engaging the alc. by SCS and capturing the resulting benzylic radical with a catalytically generated enamine. Mechanistic studies provide evidence for SCS as a key elementary step, identify the origins of competing reactions, and enable improvements in chemoselectivity by rational photocatalyst design.

Journal of the American Chemical Society published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 876919-08-3 belongs to class pyridine-derivatives, and the molecular formula is C7H6FNO2, Formula: C7H6FNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tjosaas, Freddy; Fiksdahl, Anne published the artcile< A simple synthetic route to methyl 3-fluoropyridine-4-carboxylate by nucleophilic aromatic substitution>, Product Details of C7H6FNO2, the main research area is fluoride nucleophilic aromatic substitution nitro group nitropyridinecarboxylate.

The nitro group of Me 3-nitropyridine-4-carboxylate has successfully been replaced by a fluoride anion via nucleophilic aromatic substitution to give the 3-fluoropyridine-4-carboxylate.

Molecules published new progress about 876919-08-3. 876919-08-3 belongs to class pyridine-derivatives, and the molecular formula is C7H6FNO2, Product Details of C7H6FNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Grozavu, Alexandru; Hepburn, Hamish B.; Smith, Philip J.; Potukuchi, Harish K.; Lindsay-Scott, Peter J.; Donohoe, Timothy J. published the artcile< The reductive C3 functionalization of pyridinium and quinolinium salts through iridium-catalysed interrupted transfer hydrogenation>, Category: pyridine-derivatives, the main research area is pyridinium salt formaldehyde iridium catalyst regioselective reductive hydroxymethylation; quinolinium salt formaldehyde iridium catalyst regioselective reductive hydroxymethylation; tetrahydropyridine preparation; tetrahydroquinoline preparation.

Aromatic rings are ubiquitous in organic chem. and form the basis of many com. products. Despite the numerous routes available for the preparation of aromatic compounds, there remain few methods that allow their conversion into synthetically useful partially saturated derivatives and even fewer that allow new C-C bonds to be formed at the same time. Here we set out to address this problem and uncover a unique catalytic partial reduction reaction that forms partially saturated azaheterocycles from aromatic precursors. In this reaction, methanol and formaldehyde are used for the reductive functionalization of pyridines and quinolines using catalytic iridium; thus, inexpensive and renewable feedstocks are utilized in the formation of complex N-heterocycles. By harnessing the formation of a nucleophilic enamine intermediate, the C-C bond-forming process reverses the normal pattern of reactivity and allows access to the C3 position of the arene. Mechanistic investigations using D-labeling experiments reveal the source of hydride added to the ring and show the reversible nature of the iridium-hydride addition

Nature Chemistry published new progress about C-C bond formation. 876919-08-3 belongs to class pyridine-derivatives, and the molecular formula is C7H6FNO2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Khlebnikov, Vladimir; Patel, Kalpesh; Zhou, Xiaojian; Reddy, M. Madhava; Su, Zhuoyi; Chiacchia, Fabrizio S.; Hansen, Henrik C. published the artcile< Synthesis of 2-aryl-4H-pyrano[2,3-b]pyridin-4-ones by a one-pot deprotection-cyclization reaction>, Category: pyridine-derivatives, the main research area is arylpyranopyridinone preparation deprotection cyclization.

Preparation of 2-aryl-4H-pyrano[2,3-b]pyridin-4-ones is reported. A one-pot, two-step process starting with substituted 2-alkoxynicotinates and acetophenones in the presence of pyridinium hydrochloride is used. The methodol. is compatible with a series of functional groups useful for the synthesis of second generation analogs, as part of our structure/activity relationship program. The method proved to be scalable (>100 g), allowing for efficient synthesis of material to support animal studies.

Tetrahedron published new progress about Flavonoids Role: SPN (Synthetic Preparation), PREP (Preparation). 876919-08-3 belongs to class pyridine-derivatives, and the molecular formula is C7H6FNO2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 876919-08-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 876919-08-3, name is Methyl 3-fluoroisonicotinate, molecular formula is C7H6FNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution ofPreparation 69A (100 mg, 0.42 mmol) in DMA (5 mL) wasadded methyl3-fluoroisonicotinate (65 mg, 0.42 mmol) at rt. The reaction was stirred at170 oc for 1 h in a microwave. The reaction mixture was diluted with water extracted with EtOAc. Organics were washed with brine, dried (Na2 S04), and concentrated. Purification by silica gel chromatography (5:1 PE/EtOAc) gave 50 mg (32%) of the titlecompound as a yellow solid. 1H NMR (300 MHz, CDCh): 8 3.92 (3H, s), 4.27-4.28 (2H,m), 4.81-4.82 (2H, m), 5.78-5.80 (1H, m), 7.00-7.08 (3H, m), 7.65-7.69 (2H, m), 7.97 (1H, d, J = 5.1 Hz), 8.20 (1H, s).

According to the analysis of related databases, 876919-08-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; QUANTICEL PHARMACEUTICALS, INC.; CHEN, Young, K.; KANOUNI, Toufike; NIE, Zhe; STAFFORD, Jeffrey, Alan; VEAL, James, Marvin; WALLACE, Michael, Brennan; WO2014/100818; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 876919-08-3, Adding some certain compound to certain chemical reactions, such as: 876919-08-3, name is Methyl 3-fluoroisonicotinate,molecular formula is C7H6FNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 876919-08-3.

To a suspension ofPreparation 54A (480 mg, 2.7 mmol) in DMA (5 mL) was added methyl3-fluoroisonicotinate at rt. The reaction mixture was stirred at 170 oc for 1 h in a microwave. Concentration in vacuo followed by purification by silica gelchromatography gave 395 mg (47%) of the title compound as a yellow gum. [M+H]calc’d for C1sH19FNzOz, 315; found 315.

According to the analysis of related databases, 876919-08-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; QUANTICEL PHARMACEUTICALS, INC.; CHEN, Young, K.; KANOUNI, Toufike; NIE, Zhe; STAFFORD, Jeffrey, Alan; VEAL, James, Marvin; WALLACE, Michael, Brennan; WO2014/100818; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem