Category: 877133-54-5

Adding a certain compound to certain chemical reactions, such as: 877133-54-5, 4-Bromo-2,6-diethylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 4-Bromo-2,6-diethylpyridine, blongs to pyridine-derivatives compound. Recommanded Product: 4-Bromo-2,6-diethylpyridine

Zinc cyanide (546 mg, 4.67 mmol) was added to a degassed solution of 4-bromo-2,6- diethylpyridine (500 mg, 10.8 mmol) and tetrakis(triphenylphoshpine) palladium (137 mg, 0.17 mmol) in dry DMF (5 ml_). The resulting reaction mixture was heated at 100C for 16 h. The mixture was cooled to room temperature, diluted with ethyl acetate (15 ml_) and filtered through Celite. The filter cake was washed with ethyl acetate (2 x 10 ml_). The combined organic filtrate was washed with water (10 ml_) and saturated aqueous NaCI, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The crude product was purified by flash chromatography, eluting with 40% to 60% ethyl acetate in petroleum ether, to afford 2,6-diethylisonicotinonitrile (270 mg, 73%). 1H NMR: 6H (300 MHz, DMSO-c/6) 7.56 (2H, s), 2.77 (4H, q, J 7.5), 1.23 (6H, t, 7.5).

The synthetic route of 877133-54-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MIRONID LIMITED; ADAM, Julia Mary; ADAMS, David Roger; KULKARNI, Santosh Shripad; NANDURDIKAR, Rahul Shripad; (131 pag.)WO2019/193342; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 877133-54-5, 4-Bromo-2,6-diethylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 877133-54-5, blongs to pyridine-derivatives compound. SDS of cas: 877133-54-5

-Bromo-2,6-diethylpyridine (2.9 g, 13.55 mmol), dichlorobis(trirhohenylphosphine)palladium (477 mg, 0.68 mmol) and copper(I) iodide (130 mg, 0.68 mmol) were placed in a vial and flushed with argon. Ethynyl(trimethyl)silane (2.34 mL, 16.9 mmol) and anhydrous lambdazetaiV-dimethylformamide (20 mL) were added followed by diisoproylamine (5.75 mL, 40.7 mmol). The reaction was divided into two 25 mL vials and irradiated in a microwave at 100 0C for 15 min. Water was added and the mixture was extracted with dichloromethane. The combined organic phases were concentrated in vacuo and purified by column chromatography, using a gradient of ethyl acetate (0 to 30%) in r°-heptane as the eluent, to give 1.64 g (63% yield) of the title compound: MS (ESI) m/z 111 [M+l]+.

The synthetic route of 877133-54-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTEX THERAPEUTICS LTD; WO2008/76046; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem