With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.884494-34-2, name is 2-Ethynyl-5-fluoropyridine, molecular formula is C7H4FN, molecular weight is 121.11, as common compound, the synthetic route is as follows.category: pyridine-derivatives
Step 3: Preparation of ethyl 5-(5-fluoropyridin-2-yl)isoxazole-3-carboxylate To a solution of 2-ethynyl-5-fluoropyridine (1.5 g, 12.4 mmol) in N,N-dimethylformamide (20 mL) at 23 C. was added (Z)-Ethyl 2-chloro-2-(hydroxyimino)acetate (2.81 g, 18.6 mmol). The reaction mixture stirred for 1 h before triethylamine (1.88 g, 18.6 mmol) was added. The mixture was heated at 90 C. for 16 h. The mixture was diluted with brine (100 mL), extracted with ethyl acetate (100 mL*2) and purified by column chromatography (silica, petroleum ether/ethyl acetate=20/1) to give ethyl 5-(5-fluoropyridin-2-yl)isoxazole-3-carboxylate (300 mg, 1.27 mmol, 10%) as a gray oil. LCMS (ESI) m/z: 237.1 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,884494-34-2, 2-Ethynyl-5-fluoropyridine, and friends who are interested can also refer to it.
Reference:
Patent; Yumanity Therapeutics, Inc.; WRONA, Iwona; TIVITMAHAISOON, Parcharee; TARDIFF, Daniel; PANDYA, Bhaumik; OZBOYA, Kerem; LUCAS, Matthew; BOURDONNEC, Bertrand Le; (259 pag.)US2019/330198; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem