884494-35-3 | Pyridine-derivatives

Some scientific research about 884494-35-3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 884494-35-3, 2-Chloro-5-fluoropyridin-3-ol, other downstream synthetic routes, hurry up and to see.

Electric Literature of 884494-35-3, Adding some certain compound to certain chemical reactions, such as: 884494-35-3, name is 2-Chloro-5-fluoropyridin-3-ol,molecular formula is C5H3ClFNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 884494-35-3.

Preparation 222 2-chloro-5-fluoro-3-methoxypyridine 2-chloro-5-fluoro-3-methoxypyridine (1.8 g, 72%) was prepared in an analogous manner to Preparation 153 using 2-chloro-5-fluoropyridin-3-ol (2.3 g, 16 mmol) and methanol (5 g, 156 mmol). 1H NMR (CDCl3, 400 MHz): delta 7.89 (d, J=2.70 Hz, 1H), 7.00 (dd, J=2.5, 9.1 Hz, 1H), 3.93 (s, 3H).

Reference:
Patent; Pfizer Inc.; Strohbach, Joseph Walter; Akama, Tsutomu; Blakemore, David Clive; Jacobs, Robert Toms; Jones, Peter; Limburg, David Christopher; Oderinde, Martins Sunday; Perry, Matthew Alexander; Plattner, Jacob John; Torella, Rubben Federico; Zhou, Yasheen; Yeoh, Thean Yeow; (200 pag.)US2020/108083; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some scientific research about 884494-35-3

A new synthetic route of 2-Chloro-5-fluoropyridin-3-ol

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,884494-35-3, its application will become more common.

Reference of 884494-35-3 ,Some common heterocyclic compound, 884494-35-3, molecular formula is C5H3ClFNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

tert-butyl 4-(2-chloroacetamido)piperidine-1-carboxylate (2.02 g, 7.3120 mmol) and 2-chloro-5-fluoropyridin-3-ol (1.08 g, 7.32 mmol) weredissolved in DMF (70 ml). Caesium carbonate (4.88 g, 15 mmol) was added and the mixture heated to 1 oooc for 18 hours. After cooling toroom temperature the mixture was partitioned between ethyl acetateand water and the organic phase washed with water. The organic layerwas then evaporated onto silica and purified by flash column5 chromatography eluting with 20 to 100% ethyl acetate/iso-hexane togive the title compound (2.19 g, 85% yield). 1H NMR (400 MHz, CDCb):o 7.80 (d, J=2.5 Hz, 1 H), 7.23 (dd, J=2.7, 9.0 Hz, 1 H), 4.70 (s, 2H), 4.43- 4.29 (m, 3H), 2.81 (m, 2H), 2.50 – 2.37 (m, 2H), 1.74 (dd, J=1.5, 11.6Hz, 2H), 1.50 (s, 9H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,884494-35-3, its application will become more common.

Reference:
Patent; AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.; OMBRATO, Rosella; MAGARO’, Gabriele; GAROFALO, Barbara; FURLOTTI, Guido; MANGANO, Giorgina; CAPEZZONE DE JOANNON, Alessandra; (182 pag.)WO2017/211759; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The origin of a common compound about 884494-35-3

At the same time, in my other blogs, there are other synthetic methods of this type of compound,884494-35-3, 2-Chloro-5-fluoropyridin-3-ol, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 884494-35-3, 2-Chloro-5-fluoropyridin-3-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Chloro-5-fluoropyridin-3-ol, blongs to pyridine-derivatives compound. Safety of 2-Chloro-5-fluoropyridin-3-ol

Example 319Synthesis of (1R,2S)-2-{{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}}-N-(5-fluoro-3-hydroxypyridin-2-yl)-2-(3-fluorophenyl)cyclopropanecarboxamide (319)(1) 2-chloro-5-fluoro-3-(methoxymethoxy)pyridine (319-1)A DMF (10 ml) solution of 2-chloro-5-fluoro-3-hydroxypyridine (500 mg) was cooled to 0 C. Sodium hydroxide (60% oil dispersion: 149 mg) was added to the reaction solution, and the obtained mixture was stirred at 0 C. for 15 minutes. Chloromethyl methyl ether (293 ul) was added to the reaction solution at the same temperature as described above, and the obtained mixture was heated to room temperature and stirred for 1 hour. Diethyl ether and water were added to the reaction solution, and the organic layer was successively washed with water and a saturated sodium chloride aqueous solution. The organic layer was dried over anhydrous magnesium sulfate and then filtered. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (n-heptane:ethyl acetate=19:1 to 7:3), so as to obtain the title compound (598 mg).1H-NMR (400 MHz, CDCl3) delta (ppm): 3.52 (s, 3H), 5.28 (s, 2H), 7.32 (dd, J=9.2, 2.8 Hz, 1H), 7.95 (dd, J=2.8, 0.8 Hz, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,884494-35-3, 2-Chloro-5-fluoropyridin-3-ol, and friends who are interested can also refer to it.

Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; US2012/95031; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem