Category: 884494-54-6

Related Products of 884494-54-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 884494-54-6 as follows.

Step A N-r(2-chloro-5-fluoropyridin-4-yl’)methylidenel-2-methylpropane-2-sulfinamide (1-8); A solution of 2-cMoro-5-fluoroisonicotinaldehyde (1-7, 5.0 g, 31.34 mmol), 2-methyl-2- propanesulfmamide (4.18 g, 34.47 mmol) and Ti(OEt)4 in THF (50 ml) was heated at 60 0C for 18 h. The reaction mixture was cooled to -20 0C and then 60 ml MeOH was added. The cooling bath was removed. CELITE was then added followed by a 200 ml brine wash. The resulting solids were filtered through a fritted glass funnel and washed with EtOAc. The organic portion was separated, dried (MgSO4) and concentrated in vacuo. Chromatography (hexanes to 50% EtOAc/hexanes) afforded 1-8.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,884494-54-6, its application will become more common.

Reference:
Patent; MERCK & CO., INC.; WO2007/16358; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 884494-54-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 884494-54-6 as follows.

Production Example 21-[(2-Chloro-5-fluoropyridin-4-yl)methyl]-4-methylpiperazine1-Methylpiperazine (0.42 mL), and sodium triacetoxyborohydride (811 mg) were added to a 1% acetic acid-chloroform solution (10 mL) of commercially available 2-chloro-5-fluoroisonicotinaldehyde (555 mg), and the mixture was stirred at room temperature for 5 hours. After addition of a 1 N sodium hydroxide aqueous solution, the reaction mixture was extracted with chloroform, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give a crude product of the title compound (850 mg).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,884494-54-6, its application will become more common.

Reference:
Patent; MSD K.K.; US2012/22078; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem