Category: 884495-01-6

Synthetic Route of 884495-01-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.884495-01-6, name is 4-Bromo-5-fluoro-2-hydroxypyridine, molecular formula is C5H3BrFNO, molecular weight is 191.99, as common compound, the synthetic route is as follows.

2.08 mL (26.0 mmol) Ethyl iodide and 1 .08 g (3.91 mmol) Ag2CO3 are added to a mixture of 500mg (2.160 mmol) 4-bromo-5-fluoro-pyridin-2-ol in 10 mL DCM. The mixture is stirred at r.t. over night. Then the reaction mixture is quenched by the addition of water and DCM. After filtration the org. layer is separated, dried with Na2SO4 and the solvent is removed in vacuo.C7H7BrFNO (M = 220.0 g/mol)ESI-MS: 220 [M+H]+ Rt (HPLC) : 1 .27 mm (method X)

The chemical industry reduces the impact on the environment during synthesis 884495-01-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; ROTH, Gerald Juergen; NOSSE, Bernd; HEINE, Niklas; WO2013/92616; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 884495-01-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.884495-01-6, name is 4-Bromo-5-fluoro-2-hydroxypyridine, molecular formula is C5H3BrFNO, molecular weight is 191.99, as common compound, the synthetic route is as follows.

2.08 mL (26.0 mmol) Ethyl iodide and 1 .08 g (3.91 mmol) Ag2CO3 are added to a mixture of 500mg (2.160 mmol) 4-bromo-5-fluoro-pyridin-2-ol in 10 mL DCM. The mixture is stirred at r.t. over night. Then the reaction mixture is quenched by the addition of water and DCM. After filtration the org. layer is separated, dried with Na2SO4 and the solvent is removed in vacuo.C7H7BrFNO (M = 220.0 g/mol)ESI-MS: 220 [M+H]+ Rt (HPLC) : 1 .27 mm (method X)

The chemical industry reduces the impact on the environment during synthesis 884495-01-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; ROTH, Gerald Juergen; NOSSE, Bernd; HEINE, Niklas; WO2013/92616; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 884495-01-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 884495-01-6, name is 4-Bromo-5-fluoro-2-hydroxypyridine. This compound has unique chemical properties. The synthetic route is as follows.

4-Bromo-2-ethoxy-5-fluoro-pyridine 0.20 g (1.04 mmol) 4-bromo-5-fluoro-pyridin-2-ol, 0.83 mL (10.4 mmol) ethyliodide and 0.43 g (1.56 mmol) Ag2CO3 are added to 5 mL DCM and stirred at r.t. over night. The reaction is quenched by the addition of water. DCM is added, the resulting mixture is filtered and the organic layer is separted, dried over MgSO4, filtered again and the solvent is removed in vacuo. C7H7BrFNO (M=220.0 g/mol) ESI-MS: 220/222 [M+H]+Rt(HPLC):1.27 min (method B)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 884495-01-6, 4-Bromo-5-fluoro-2-hydroxypyridine.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; HEINE, Niklas; NOSSE, Bernd; ROTH, Gerald Juergen; US2014/213568; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 884495-01-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 884495-01-6, name is 4-Bromo-5-fluoro-2-hydroxypyridine. This compound has unique chemical properties. The synthetic route is as follows.

0.20 g (1.04 mmol) 4-bromo-5-fluoro-pyridin-2-ol, 0.83 mL (10.4 mmol) ethyliodide and 0.43 g ( .56 mmol) Ag2C03 are added to 5 mL DCM and stirred at r.t. over night. The reaction is quenched by the addition of water. DCM is added, the resulting mixture is filtered and the organic layer is separted, dried over MgS04, filtered again and the solvent is removed in vacuo. C7H7BrFNO (M= 220.0 g/mol) ESI-MS: 220/222 [M+H]+ Rt (HPLC):1.27 min (method B)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 884495-01-6, 4-Bromo-5-fluoro-2-hydroxypyridine.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; HEINE, Niklas; NOSSE, Bernd; ROTH, Gerald Juergen; WO2014/114578; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 884495-01-6 ,Some common heterocyclic compound, 884495-01-6, molecular formula is C5H3BrFNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

4-Bromo-2-ethoxy-5-fluoropyridine 2.08 mL (26.0 mmol) Ethyliodide and 1.08 g (3.91 mmol) Ag2CO3 are added to a mixture of 500 mg (2.160 mmol) 4-bromo-5-fluoro-pyridin-2-ol in 10 mL DCM. The mixture is stirred at r.t. over night. Then the reaction mixture is quenched by the addition of water and DCM. After filtration the org. layer is separated, dried with Na2SO4 and the solvent is removed in vacuo. C7H7BrFNO (M=220.0 g/mol) ESI-MS: 220 [M+H]+Rt (HPLC): 1.27 min (method X)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,884495-01-6, its application will become more common.

Reference:
Patent; FLECK, Martin; NOSSE, Bernd; HEINE, Niklas; ROTH, Gerald Juergen; US2013/158004; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 884495-01-6, Adding some certain compound to certain chemical reactions, such as: 884495-01-6, name is 4-Bromo-5-fluoro-2-hydroxypyridine,molecular formula is C5H3BrFNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 884495-01-6.

A mixture of 4-bromo-5-fluoropyridin-2-ol (442 mg, 2.31 mmol), ethyl 2-iodo-4-methylpentanoate (937 mg, 3.47 mmol) and K2CO3 (958 mg, 6.94 mmol) in MeCN (10 mL) was stirred at 85 C. overnight and filtered. The filtrate was concentrated in vacuo, and the residue was purified by silica gel column (pet. ether_EtOAc=4:1) to give the desired product ethyl 2-(4-bromo-5-fluoro-2-oxopyridin-1(2H)-yl)-4-methylpentanoate as a colorless oil (402 mg). Yield 52% (97% purity, UV=214 nm, ESI 334.0 (M+H)+).

According to the analysis of related databases, 884495-01-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Morphic Therapeutic, Inc.; Bursavich, Matthew G.; Troast, Dawn M.; Harrison, Bryce A.; Lippa, Blaise S.; Rogers, Bruce N.; Konze, Kyle D.; Gerasyuto, Aleksey I.; Day, Tyler; Lin, Fu-Yang; Hahn, Kristopher N.; Svensson, Mats A.; Kim, Byungchan; Zhong, Cheng; Lugovskoy, Alexey A.; Sosa, Brian; (263 pag.)US2019/315692; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem