With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.88482-17-1, name is 5-Amino-2-methylisonicotinic acid, molecular formula is C7H8N2O2, molecular weight is 152.15, as common compound, the synthetic route is as follows.Quality Control of 5-Amino-2-methylisonicotinic acid
Preparation 2 6-Methyl-pyrido[3,4-d]pyrimid-4-one 5-Amino-2-methyl-4pyridinecarboxylic acid was prepared according to Palt, K.; Celadnik, M.; Dvorackova, D.; Kubala, E., Cesk. Farm., 32(8), 275-278 (1983). This carboxylic acid was converted to the title product by heating in formamide at 165 C. according to the procedure of Robins, R.; Hitchings, G.; J. Am. Chem. Soc. 77, 2256 (1965).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,88482-17-1, 5-Amino-2-methylisonicotinic acid, and friends who are interested can also refer to it.
Reference:
Patent; Pfizer Inc; US6395733; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem