Synthetic Route of 885269-66-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.885269-66-9, name is 6-Methyl-1H-pyrazolo[3,4-b]pyridine, molecular formula is C7H7N3, molecular weight is 133.15, as common compound, the synthetic route is as follows.
To a brown solution of 6-methyl-1H-pyrazolo[3,4-bjpyridine (1.3 g, 9.4 mmol) and iodine (4.8 g, 19 mmol) in DMF (30 mL) at 0 C was KOH (2.lg, 38 mmol). The reaction was allowed to warm to ambient temperature and stir for an hour. The resultant mixture was poured into ice/water (200 mL) and extracted with EtOAc (3 x 200 mL). The combined organic layers were dried over Na2504, filtered and concentrated in vacuo. Purification using silica gel chromatography (30-50% EtOAc/hexanes gradient) afforded 3-iodo-6-methyl- 1H- pyrazolo[3,4-bjpyridine as a light yellow solid (1.8 g, 74% yield).
The chemical industry reduces the impact on the environment during synthesis 885269-66-9, I believe this compound will play a more active role in future production and life.
Reference:
Patent; IRONWOOD PHARMACEUTICALS, INC.; RENNIE, Glen, Robert; BARDEN, Timothy, Claude; LEE, Thomas, Wai-Ho; IYENGAR, Rajesh, R.; NAKAI, Takashi; MERMERIAN, Ara; JIA, James; IYER, Karthik; IM, G-Yoon, Jamie; RENHOWE, Paul, Allan; JUNG, Joon; GERMANO, Peter; TANG, Kim; (240 pag.)WO2018/89330; (2018); A2;,
Pyridine – Wikipedia,
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