Category: 886364-86-9

Related Products of 886364-86-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 886364-86-9, name is 5-Bromo-4-methylpicolinonitrile. A new synthetic method of this compound is introduced below.

A mixture of (±)-trans-N-(6-bromo-8-chloroisoquinolin-3-yl)-2-cyanocyclopropane-1-carboxamide (125 mg, 0.571 mmol), bis(pinacolato)diboron (222 mg, 0.856 mmol), potassium acetate (168 mg, 1.711 mmol), and Pd(dppf)Cl2 (42.2 mg, 0.0571 mmol) in 1,4-dioxane (3 mL) was heated in a microwave at 130 C. for 45 minutes to give (±)-(8-chloro-3-((trans-2-cyanocyclopropane-1-carboxamido)isoquinolin-6-yl)boronic acid. LCMS (ESI): [M+H]+=316.0. (0975) 5-Bromo-4-methylpicolinonitrile (168 mg, 0.856 mmol) and sodium carbonate (1 mol/L) in water (2.85 ml, 2.852 mmol) were then added. The reaction mixture was heated in a microwave at 90 C. for 55 minutes. The organic layer was purified with silica gel column chromatography (0.5 to 9% methanol in dichloromethane) to give (±)-(trans-N-(8-chloro-6-(6-cyano-4-methylpyridin-3-yl)isoquinolin-3-yl)-2-cyanocyclopropane-1-carboxamide (187 mg, 86.5% yield). LCMS (ESI) [M+H]+=388.0.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,886364-86-9, 5-Bromo-4-methylpicolinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Genentech, Inc.; Chan, Bryan; Drobnick, Joy; Gazzard, Lewis; Heffron, Timothy; Liang, Jun; Malhotra, Sushant; Mendonca, Rohan; Rajapaksa, Naomi; Stivala, Craig; Tellis, John; Wang, Weiru; Wei, BinQing; Zhou, Aihe; Cartwright, Matthew W.; Lainchbury, Michael; Gancia, Emanuela; Seward, Eileen; Madin, Andrew; Favor, David; Fong, Kin Chiu; Hu, Yonghan; Good, Andrew; US2018/282282; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 886364-86-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 886364-86-9, name is 5-Bromo-4-methylpicolinonitrile, molecular formula is C7H5BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5-bromo-4-methyl-2-(2H-tetrazol-5-yl)-pyridine:To a mixture of 5-bromo-4-methylpicolinonitrile (2.5 g, 12.7 mmol, Eq: 1.00), sodium azide (1.07 g, 16.5 mmol, Eq: 1.3) and triethylamine hydrochloride (2.27 g, 16.5 mmol, Eq: 1.3) was added xylene (25 ml). The reaction mixture was heated at 140 C. overnight, and upon cooling was concentrated under reduced pressure. To the white residue was added water and an aq. HCl solution. These solids were filtered, washed with water, and dried to give 5-bromo-4-methyl-2-(2H-tetrazol-5-yl)-pyridine (2.43 g, 80% yield) as an off-white solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 886364-86-9, 5-Bromo-4-methylpicolinonitrile.

Reference:
Patent; Hoffmann-La Roche Inc; Bhagirath, Niala; Brameld, Kenneth Albert; Kennedy-Smith, Joshua; US2013/90334; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 886364-86-9, Adding some certain compound to certain chemical reactions, such as: 886364-86-9, name is 5-Bromo-4-methylpicolinonitrile,molecular formula is C7H5BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 886364-86-9.

A mixture of 4-chloro-N-(2-hydroxy-phenyl)-N-methyl-3-(4,4,5,5- tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-benzamide (100 mg, 0.26 mmol), 5-bromo-4- methyl-pyridine-2-carbonitrile (61 mg, 0.31 mmol), Pd(PPh3)4 (15 mg, 0.013 mmol), K2CO3 (90 mg, 0.65 mmol) in dioxane (1.2 mL), was heated at 95 0C for 12 hrs. The mixture was diluted with EtOAc, washed with water and brine, dried (Na2SO4) and concentrated in vacuo. Silica gel column chromatography (eluent: ethyl acetate/hexane(1/4 up to 4/1 )) yielded 4-chloro-3-(6-cyano-4-methyl-pyridin-3-yl)-N-(2- hydroxy-phenyl)-N-methyl-benzamide 8-1 (68 mg).

According to the analysis of related databases, 886364-86-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NEUROCRINE BIOSCIENCES, INC.; WO2008/124610; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem