Category: 886365-28-2

Adding a certain compound to certain chemical reactions, such as: 886365-28-2, Methyl 5-bromo-2-chloroisonicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: Methyl 5-bromo-2-chloroisonicotinate, blongs to pyridine-derivatives compound. name: Methyl 5-bromo-2-chloroisonicotinate

To a mixture of methyl 5-bromo-2-chloroisonicotinate (10 g, 39.9 mmol) and Pd(Ph3P)4(4.61 g, 3.99 mmol) in THF (100 mL) was added trimethylaluminum (26.0 mL, 51.9 mmol) at 25C. The mixture was then heated to and stirred at 80 C for 6 h. Water (5 mL) was added toquench the reaction and the mixture was concentrated in vacuum. The residue was purified by flash silica gel chromatography (eluting with ethyl acetate/pet. ether gradient) to give methyl 2- chloro-5-methylisonicotinate as a colorless oil. MS: 186 (M + 1). ?HNMR (400 MHz, CDC13) 8.29 (s, 1H), 7.70 (s, 1H), 3.91 (s, 3H), 2.49 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,886365-28-2, Methyl 5-bromo-2-chloroisonicotinate, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; CTXT PTY. LTD.; MACHACEK, Michelle, R.; WITTER, David, J.; REUTERSHAN, Michael Hale; ALTMAN, Michael, D.; STUPPLE, Paul Anthony; (67 pag.)WO2019/94311; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 886365-28-2, name is Methyl 5-bromo-2-chloroisonicotinate. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 886365-28-2

Methyl 5-bromo-2-chloro isonicotinate (30 g, 120 mmol) was dissolved in 1,4-dioxane (300 mL), and 3,5-dimethoxyphenylacetylene (20.4 g, 120 mmol), CuI (2.28 g, 12 mmol), Pd(dppf)Cl2 (4.2 g, 6 mmol) and Et3N (12.0 g, 120 mmol) were added, and the mixture was heated to 60 C. under N2, for 6 h. The reaction was complete, and the mixture was filtered and concentrated. The crude product was separated by silica gel column chromatography (DCM:PE=20:1) to obtain compound methyl 2-chloro-5-((3,5-dimethoxyphenyl)ethynyl)isonicotinate (22 g, yield: 55%). MS (ESI): m/z 332.1 [M+1]+.

With the rapid development of chemical substances, we look forward to future research findings about 886365-28-2.

Reference:
Patent; Abbisko Therapeutics Co., Ltd.; YANG, Fei; DENG, Haibing; YING, Haiyan; YU, Hongping; CHEN, Zhui; XU, Yaochang; (604 pag.)US2019/270742; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem