Category: 886365-56-6

Electric Literature of 886365-56-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 886365-56-6, name is 5-Fluoro-3-methylpyridin-2-ylamine. A new synthetic method of this compound is introduced below.

A mixture of 5-fluoro-3-methylpyridin-2-amine (3.3 g, 26.2 mmol) and dimethyl malonate (15.0 mL, 0.13 mol, 5.0 eq.) was heated at 210 C for 1.5 hours. After cooling to room temperature, the precipitate was filtered and washed with ACN (3x) to give 7-fluoro-2-hydroxy- 9-methyl-pyrido[1,2-a]pyrimidin-4-one as a dark solid (2.3 g), which was used directly in thenext step. MS m/z 195.1 [M+Hf?.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,886365-56-6, 5-Fluoro-3-methylpyridin-2-ylamine, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; ALSENZ, Jochem; GRASSMANN, Olaf; KUEHL, Peter; METZGER, Friedrich; MCCARTHY, Kathleen Dorothy; MORAWSKI VIANNA, Eduardo Paulo; WOODHOUSE, Marvin Lloyd; (130 pag.)WO2017/80967; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 886365-56-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 886365-56-6 as follows.

A mixture of 5-fluoro-3-methylpyridin-2-amine (3.3 g, 26.2 mmol) and dimethyl malonate(15.0 mL, 0.13 mol, 5.0 eq.) was heated at 210 C for 1.5 h. After cooling to room temperature,the precipitate was filtered and washed with ACN (3x) to give 7-fluoro-2-hydroxy-9-methyl- pyrido[1,2-a]pyrimidin-4-one as a dark solid (2.3 g), which was used directly in the next step. MS mlz 195.1 [M+H].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,886365-56-6, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GILLESPIE, Robert Jack; HASANE, Ratni; SARIE, Jerome Charles; (89 pag.)WO2016/184832; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem