Related Products of 887147-19-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 887147-19-5 as follows.
General procedure: Similar to as described in General Procedure U, 4,6-dichloro-1-methyl-1H-imidazo[4,5-c]pyridine was reacted with potassium(R)-trifluoro(3 -((3-hydroxy- 1 -methyl-2-oxopyrrolidin-3-yl)ethynyl)phenyl)borate to give the titlecompound (80 mg, 20%) as a yellow solid. LC-MS (ES, m/z): 381 [M+H]. A tube containing a solution of arylchloride/bromide (1 eq) and aryltrifluoroborate (1 eq) in Ethanol was purged with nitrogen before addition of Pd(OAc)2 (0.06 eq), RuPhos (0.12 eq), and Sodium Carbonate (2 eq). The tube was sealed with a cap lined with a disposable Teflon septum was heated at 85 C for 12-20 hours. The reaction mixture was allowedto cool to room temperature and was either filtered through Celite and submitted directly to reverse phase HPLC purification or extracted with dichloromethane and a solution of saturated ammonium chloride before drying, evaporating and submitting to reverse phase purification or using in the subsequent step without purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,887147-19-5, its application will become more common.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BLAQUIERE, Nicole; BURCH, Jason; CASTANEDO, Georgette; FENG, Jianwen A.; HU, Baihua; LIN, Xingyu; STABEN, Steven; WU, Guosheng; YUEN, Po-wai; WO2015/25026; (2015); A1;,
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