Category: 887583-90-6

Adding a certain compound to certain chemical reactions, such as: 887583-90-6, 4-Bromo-2-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H3BrF3N, blongs to pyridine-derivatives compound. COA of Formula: C6H3BrF3N

A solution of isopropylmagnesium chloride/lithium chloride complex (1.3 M in THF, 10.6 mL, 13.8 mmol) was added dropwise by syringe to a solution of 4-bromo-2-(trifluoromethyl)pyridine (3.12 g, 13.8 mmol) in dry THF (50 mL) at 0 C. After 30 minutes, a solution of 1-methyl-1H-imidazole-5-carbaldehyde (1.38 g, 12.5 mmol) in THF (28.5 mL) was added to the Grignard solution by syringe at 0 C. The reaction mixture was warmed to room temperature over 2 hours after which it was quenched with saturated aqueous ammonium chloride solution. The mixture was partitioned between water and ethyl acetate. The separated aqueous phase was further extracted with ethyl acetate and washed with saturated aqueous NaCl solution. The organic phase was dried (MgSO4), filtered, and concentrated. The crude product was purified by flash column chromatography (silica gel, 0-10% MeOH-DCM) to provide the title compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,887583-90-6, 4-Bromo-2-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; Janssen Pharmaceutica NV; Leonard, Kristi A.; Barbay, Kent; Edwards, James P.; Kreutter, Kevin D.; Kummer, David A.; Maharoof, Umar; Nishimura, Rachel; Urbanski, Maud; Venkatesan, Hariharan; Wang, Aihua; Wolin, Ronald L.; Woods, Craig R.; Fourie, Anne; Xue, Xiaohua; Cummings, Maxwell D.; Jones, William Moore; Goldberg, Steven; US2015/105366; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 887583-90-6, name is 4-Bromo-2-(trifluoromethyl)pyridine, the common compound, a new synthetic route is introduced below. name: 4-Bromo-2-(trifluoromethyl)pyridine

To a solution of 4-bromo-2- (trifluoromethyl) pyridine (190 g, 840.7 mmol) in THF (1300 mL) cooled to 0 under nitrogen was added isopropylmagnesium chloride (THF, 2N, 462mL, 924.8 mmol) dropwise over 30 min while maintaining the temperature below 5 . After addition, the mixture was stirred below 10 for 30 min and recooled to 0 . Acetaldehyde (55.48 g, 1261 mmol) was added dropwise while maintaining the temperature below 10 . After addition, the mixture was stirred below 10 for 30 min before quenching with aqeous NH4Cl (saturated, 500mL) . The mixture was concentrated in vacuo to remove most THF. The aqueous phase was extracted with EtOAc (1.0 L ¡Á 3) . The combined organic extracts were washed with H2O (500 mL ¡Á 3) , brine (500 mL ¡Á 2) , dried over anhydrous sodium sulfate, filtered off, and concentrated in vacuo to give the crude title compound (150 g, yield: 93%) , which was used in the next step without further purification..

The synthetic route of 887583-90-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JS INNOPHARM (SHANGHAI) LTD; ZHANG, Jintao; XU, Wen; JIAN, Shanzhong; LI, Qun; (166 pag.)WO2019/37640; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem