Category: 88912-25-8

Synthetic Route of 88912-25-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 88912-25-8, name is 4,6-Dichloropicolinic acid. A new synthetic method of this compound is introduced below.

Preparation of 1-72: A stirred solution of 1-71 (20.0 g, 104.1 mmol) in CH3OH (200 mL) was charged with cone H2SO4 (1.0 mL) at RT. The reaction mixture was heated at 70C for 2 h. The reaction mixture was concentrated under reduced pressure, diluted with EtOAc (100 mL) and poured into saturated NaHCC solution (80 mL). The layers were separated and the aqueous layer was extracted with EtOAc (2 chi 150 mL). The combined organic layer was washed with water (100 mL) and brine (100 mL). The organic layer was dried over anhydrous Na2S04 and concentrated under reduced pressure to afford 1-72 as a liquid. (0264) MS (MM) m/z 207.1 [M + H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,88912-25-8, 4,6-Dichloropicolinic acid, and friends who are interested can also refer to it.

Reference:
Patent; IOMET PHARMA LTD.; MERCK SHARP & DOHME CORP.; COWLEY, Phillip, M.; MCGOWAN, Meredeth Ann; BROWN, Thomas, J.; HAN, Yongxin; LIU, Kun; PU, Qinglin; WISE, Alan; ZHANG, Hongjun; ZHOU, Hua; (70 pag.)WO2017/189386; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 88912-25-8, name is 4,6-Dichloropicolinic acid. A new synthetic method of this compound is introduced below., SDS of cas: 88912-25-8

To a stirred solution of 71 (20.0 g, 104.1 mmol) in CH3OH (200 mL) was charged with conc H2S04 (1.0 mL) at room temperature. The reaction mixture was heated at 70C for 2 h. The reaction mixture was concentrated under reduced pressure, diluted with EtOAc (100 mL) and poured into saturated NaHCO3 solution (80 mL). The layers wereseparated and the aqueous layer was extracted with EtOAc (2450 mL). The combined organic layer was washed with water (100 mL) and brine (100 mL). The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford 72 [20.0 g (crude)j as a liquid. MS (MM) m/z 207.1 [M + Hj.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 88912-25-8, 4,6-Dichloropicolinic acid.

Reference:
Patent; IOMET PHARMA LTD.; MERCK SHARP & DOHME CORP.; COWLEY, Phillip, M.; WISE, Alan; BROWN, Thomas, J.; MCGOWAN, Meredeth, A.; ZHOU, Hua; HAN, Yongxin; (223 pag.)WO2017/7700; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem