Category: 88912-26-9

Application of 88912-26-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 88912-26-9 as follows.

THF (25 ml_), 2-{4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2- fluorophenyl}acetohydrazide (700 mg, 1.98 mmol), 2,5-dichloro-4-pyridinecarboxylic acid (380 mg, 1.98 mmol), HATU (380 mg, 1.98 mmol) and DIPEA (0.700 ml_, 3.96 mmol) were combined and stirred at rt for 45 min. Burgess Reagent (2.36 g, 9.90 mmol) was added and the reaction stirred overnight. The reaction mixture was diluted with ethyl acetate and washed with water. The solvent was removed and the crude material purified via silica gel chromatography to give 340 mg of the title compound. 1H NMR (DMSO-d6) delta 8.74 (s, 1 H), 7.98 (s, 1 H), 7.77 (m, 1 H), 7.50 (m, 3 H), 7.46 (m, 1 H), 4.50 (s, 2 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,88912-26-9, its application will become more common.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/157273; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 88912-26-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.88912-26-9, name is 2,5-Dichloroisonicotinic acid, molecular formula is C6H3Cl2NO2, molecular weight is 192, as common compound, the synthetic route is as follows.

To a 10000-mL 4-necked round-bottom flask, purged and maintained with an inert atmosphere of nitrogen, was placed 2,5-dichloropyridine-4-carboxylic acid (200 g, 1.04 mol, 1.00 equiv) and tetrahydrofuran (2000 mL), followed by the addition of BH3-THF (3140 mL, 3.00 equiv, 1M) dropwise with stirring at 0 C. The resulting solution was stirred at room temperature for 2 h, quenched by the addition of 2000 mL of water, and extracted with 3×1500 mL of ethyl acetate. The combined organic layers were washed with 2×1500 mL of water, 3×1500 mL of brine, dried over anhydrous sodium sulfate and concentrated under vacuum to afford 140 g (75percent) of (2,5- dichloropyridin-4-yl)methanol as a white solid.

The chemical industry reduces the impact on the environment during synthesis 88912-26-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; VERMA, Vishal; SHORE, Daniel; VOLGRAF, Matthew; ESTRADA, Anthony A.; LYSSIKATOS, Joseph; (153 pag.)WO2018/15410; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 88912-26-9, Adding some certain compound to certain chemical reactions, such as: 88912-26-9, name is 2,5-Dichloroisonicotinic acid,molecular formula is C6H3Cl2NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 88912-26-9.

To a methanolic solution of 2, 5-dichloro- isonicotinic acid was added H2SO4 (cone) (0.5 mL) and the solution was heated to reflux for 12 h. The mixture was cooled to room temperature, neutralized with aqueous NaHCO3, extracted into EtOAc and evaporated to afford the methyl ester (6-2) in 89% yield.

According to the analysis of related databases, 88912-26-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIOTA SCIENTIFIC MANAGEMENT PTY LTD; WO2008/141385; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem