Category: 889676-37-3

Electric Literature of 889676-37-3 ,Some common heterocyclic compound, 889676-37-3, molecular formula is C6H5BrN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 1-11: tert-Butyl 6-r5-carbamoylpyridin-2-ylV4-oxospirorchroman-2,4′-pirhoeridmel-r-carboxylatel’-tert-butoxycarbonyl-6-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)spiro[chroman-2,4′-piperidm]-4-one (40.0 g, 90.0 mmol), 6-chloronicotinamide (17.0 g, 108 mmol), Pd(PPh3)4 (5.21 g, 4.51 mmol), and aqueous 2M Na2CO3 (100 ml) solution were suspended in dioxane (300 ml) and heated at 100C for 16 h. The reaction mixture was diluted with CEtaCI3 and H2O, the aqueous layer was extracted with CHCI3. The combined organic layer was washed with brine, dried over MgSCvj. and silicagel. The desiccant was removed through celite filtration and the filtrate was concentrated under reduced pressure. The resulting residue was purified by crystallization (CHCI3 -EtOAc) to obtain the intended compound as a colorless solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,889676-37-3, its application will become more common.

Reference:
Patent; BANYU PHARMACEUTICAL CO.,LTD.; JONA, Hideki; SHIBATA, Yoshihiro; YAMAKAWA, Takeru; WO2010/2010; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 889676-37-3 ,Some common heterocyclic compound, 889676-37-3, molecular formula is C6H5BrN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-methoxybenzofuran boronic acid (1.2 mmol), 6-bromonicotinamide (1.0 mmol), Pd(PPh3)2Cl2 (0.024 mmol) and NEt3 (317 muL) were mixed in EtOH (10 mL) in a 20 mL microwave vial. The mixture was stirred at 140 C. for 10 min in a microwave reactor. The mixture was filtered, the obtained precipitate was washed with water and EtOAc and dried under vacuum to afford the title compound (85 mg). 1H NMR delta ppm 9.14 (d, 1H) 8.42 (dd, 1H) 7.97-8.25 (m, 2H) 7.63-7.80 (m, 2H) 7.58 (d, 1H) 7.22 (d, 1H) 6.98 (dd, 1H) 3.81 (s, 3H); MS m/z 269 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 889676-37-3, 6-Bromonicotinamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AstraZeneca AB; US2008/221149; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem