Category: 89-00-9

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.89-00-9, name is Pyridine-2,3-dicarboxylic acid, molecular formula is C7H5NO4, molecular weight is 167.1189, as common compound, the synthetic route is as follows.COA of Formula: C7H5NO4

Pyridine-2,3-dicarboxylic acid 43.1 (20 g, 121 mmol) was dissolved in methanol (400 ml) then concentrated sulfuric acid (12.9 ml, 242 mmol) was added and the mixture was stirredreflux for 18 h. The volatiles were removed, and the liquid poured carefully into saturatedsodium carbonate. The pH was adjusted to 7 with sodium carbonate then extracted threetimes with ethyl acetate. The organic layer was dried over magnesium sulfate, filtered andevaporated to provide compound 43.2 (19.5 g, 83percent) as an oil. 1H NMR (CDCI3, 300 MHz)3.96 (5, 3H), 4.04 (5, 3H), 7.50 (dd, 1H), 8.17 (d, 1H), 8.76 (d, 1H). UPLC (CSH 2-50percent)0.57 (196 [M+H]) 99percent.

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Reference:
Patent; THE UNIVERSITY OF SHEFFIELD; RICHARDS, Gareth; SKERRY, Timothy, M.; HARRITY, Joseph, P.A.; ZIRIMWABAGABO, Jean-Olivier; TOZER, Matthew, J.; GIBSON, Karl, Richard; PORTER, Roderick, Alan; BLANEY, Paul, Matthew; GLOSSOP, Paul, Alan; (369 pag.)WO2018/211275; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89-00-9, name is Pyridine-2,3-dicarboxylic acid, the common compound, a new synthetic route is introduced below. category: pyridine-derivatives

A solution of pyridine-2,3-dicarboxylic acid (0.5 g, 3 mmol) and NaOH (0.24 g, 6 mmol) in water (25 mL) was added dropwise with stirring at 60 C to a solution of CdSO4·8/3H2O (0.77 g, 3 mmol) in water (25 mL). A precipitate immediately formed and stirring was continued for 4 h at 50 C. The addition of the 2-meim ligand (0.49 g, 6 mmol) in water (10 mL) to the precipitate mixture resulted in a clear solution. The mixture was stirred for 2 h at 60 C and then cooled to room temperature. The crystals that formed were filtered, washed with 10 mL of water, and dried in air. The crystals were collected for 1 in 69.3% yield. Anal. Calc. for C11H9CdN3O4: C, 36.74; H, 2.52; N, 11.68. Found: C, 36.67; H, 2.71; N, 11.52%.

The synthetic route of 89-00-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Semerci, Fatih; Ye?ilel, Okan Zafer; Soylu, Mustafa Serkan; Keskin, Seda; Bueyuekguengoer, Orhan; Polyhedron; vol. 50; 1; (2013); p. 314 – 320;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 89-00-9 , The common heterocyclic compound, 89-00-9, name is Pyridine-2,3-dicarboxylic acid, molecular formula is C7H5NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Pyridine-2,3-dicarboxylic acid (8.40 g, 50.30 mmol, 1 eq) was suspended in acetic anhydride (11.0 mL, 116.50 mmol, 2.3 eq) and the mixture was heated at 120 C, distilling 9.5 mL of acetic acid. After cooling at 100 C the acetamide (6.70 g, 113.60 mmol, 2.2 eq) was added portionwise in 5 min. The reaction was then heated at reflux for 2.5 h. After cooling at room temperature, the precipitate was filtered off and washed with water (2 * 12 mL) to give the desired product as grey solid after crystallization with EtOH/H2O 95:5 (3.46 g, 47%). Mp. 230-231 C. 1H NMR (300 MHz, DMSO-d6) delta 11.63 (br s, NH), 8.93 (d, J = 4.9 Hz, 1-H), 8.22 (d, J = 7.7 Hz, 1-H), 7.74 (dd, J = 7.6/4.9 Hz, 1-H). IR (KBr) 3483, 3189, 3100, 1735, 1704 cm-1.

The synthetic route of 89-00-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Galli, Ubaldina; Mesenzani, Ornella; Coppo, Camilla; Sorba, Giovanni; Canonico, Pier Luigi; Tron, Gian Cesare; Genazzani, Armando A.; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 58 – 66,9;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 89-00-9, Pyridine-2,3-dicarboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Pyridine-2,3-dicarboxylic acid, blongs to pyridine-derivatives compound. Safety of Pyridine-2,3-dicarboxylic acid

Synthesis of complex III was similar to that of II except that BaCl2 (0.105 g, 0.5 mmol) was used instead of FeCl2*4H2O (0.1268 g, 1 mmol). The pH was adjusted into 6, the mixture keep under autogenous pressure in 120C for 78 h, and then slowly cooled to room temperature at a rate of 5C/h. Then white crystals suitable for X-ray diffraction were separated and washed with water, which were stable in air and insoluble in water and common white solvents. The yield was 58% based on Ba.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,89-00-9, Pyridine-2,3-dicarboxylic acid, and friends who are interested can also refer to it.

Reference:
Article; Huang; Shi; Liu; Xiao; Yin; Russian Journal of Coordination Chemistry; vol. 41; 5; (2015); p. 325 – 333; Koord. Khim.; vol. 41; 5; (2015); p. 325 – 333,9;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 89-00-9 , The common heterocyclic compound, 89-00-9, name is Pyridine-2,3-dicarboxylic acid, molecular formula is C7H5NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

take 1mol2,3-pyridinedicarboxylic acid, 1.15mol urea ground into a fine powder mixture,Add 1000ml three-necked flask, purged with nitrogen and heated to 189 ,After melting, stirring for 20 min, cooling to room temperature, to give2,3-pyridine diimide;

The synthetic route of 89-00-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shanghai Wokai Biological Co., Ltd.; Lu Huiyi; Guo Jianguo; Wang Tao; Zhou Yin; (5 pag.)CN106083846; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 89-00-9, Name is Pyridine-2,3-dicarboxylic acid, SMILES is O=C(C1=NC=CC=C1C(O)=O)O, in an article , author is Zhong, Xiuli, once mentioned of 89-00-9, Formula: https://www.ambeed.com/products/89-00-9.html.

A mitochondria-targeted fluorescent probe based on coumarin-pyridine derivatives for hypochlorite imaging in living cells and zebrafish

Hypochlorite plays a critical role in various physiological processes and is involved in many diseases. Thus, real-time, rapid, and accurate monitoring of hypochlorite has important medical and physiological significance. Herein, a novel coumarin-pyridine derivative (CPD) probe was designed and synthesized, which exhibited fantastic advantages, such as a rapid response (within 10 s), naked eye recognition, large Stokes shift (185 nm), dual-channel detection, and high selectivity and sensitivity toward OCl- (detection limit 0.012 mu M, S/N = 3). Furthermore, the current CPD probe was successfully used to image OCl- in the mitochondria of both A549 cells and zebrafish, which further demonstrated its suitability for practical applications in biological systems.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Rawat, Deepa, once mentioned the application of 89-00-9, Name is Pyridine-2,3-dicarboxylic acid, molecular formula is C7H5NO4, molecular weight is 167.1189, MDL number is MFCD00006295, category is pyridine-derivatives. Now introduce a scientific discovery about this category, Application In Synthesis of Pyridine-2,3-dicarboxylic acid.

Pd-Catalyzed ortho Selective C-H Acyloxylation and Hydroxylation of Pyridotriazoles

An efficient protocol for the palladium-catalyzed direct ortho C-H acyloxylation of 3-phenyl-pyridotriazoles is described. The reaction was facilitated by PhI(OAc)(2) (PIDA) as an oxidant and with carboxylic acids as acyloxylation reagents. The reaction is highly selective for mono acyloxylation of pyridotriazoles with various acids such as aliphatic, branched, and cyclic including adamantane carboxylic acids. When acetic anhydride was employed as acylation reagent, interesting 2-oxo-1-phenyl-1-(pyridin-2-yl)propyl acetates were obtained through the ring opening of pyridotriazoles. The key strategy is the employment of pyridotriazoles as a modifiable heterocycle; acyloxylation followed by the hydrolysis in one pot to yield the potential drug intermediates [(2-hydroxyphenyl)pyridin-2-yl]methanone in good yields.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 89-00-9, Name is Pyridine-2,3-dicarboxylic acid. In a document, author is Nde, H. Soh, introducing its new discovery. SDS of cas: 89-00-9.

Comparison of HCl and H2SO4 for the acid activation of a cameroonian smectite soil clay: palm oil discolouration and landfill leachate treatment

Vertisols occupy approximately 1,200,000 ha in Northern Cameroon. Their richness in smectites allows for the production of bleaching earths necessary for refining palm oil, and their effluent is used for leachate treatment. In the present work, two mineral acids (HCl and H2SO4) were compared, and the most efficient acid with the lowest cost was determined for use in industrial applications. Under similar experimental conditions (ratio of acid solution/clay mass = 5/1, temperature = 97 degrees C, stirring time = 4 h), the quantity of cations (Fe2+, Fe3+, Al3+) solubilised during acid activation, palm oil discolouration rate by each activated sample and the financial cost of 5 L of acid solution that is required for the acid activation of one kilogram of smectite clay were compared. It was found that 2N H2SO4 was more efficient than 1N HCl and 1N H2SO4, considering palm oil bleaching efficiency and cost. The filtrate collected after the acid activation of vertisols was rich in H+ (2.04.10(-1)M), Fe2+ (2.8.10(-3)M), Fe3+ (4.2.10(-2)M) and Al3+ (9.2.10(-2)M) ions. One gram of smectite clay material produced 9 mL of this filtrate that was used for the treatment of leachate from a controlled landfill. The leachate colour decreased from 4262 to 285 PtCo units, while the corresponding chemical oxygen demand (COD) decreased from 802 to 128 mg/L. Thus, the most effective acid for industrial bleaching earth production from vertisol is 2N H2SO4 acid.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 89-00-9 help many people in the next few years. SDS of cas: 89-00-9.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is an experimental science, Name: Pyridine-2,3-dicarboxylic acid, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 89-00-9, Name is Pyridine-2,3-dicarboxylic acid, molecular formula is C7H5NO4, belongs to pyridine-derivatives compound. In a document, author is Nagaraj, K..

Microheterogeneous mediated electron transfer reaction (ETR) of surfactant cobalt(III) complexes by Fe2+ : Effect of pyridine substituent as co ligand

The outer sphere electron transfer reaction of surfactant cobalt(III) complexes, Cis[Co(en)(2)(4CNP)(C12H25NH2)](ClO4)(3) 1, Cis-[Co(trien)(4CNP)(C12H25NH2)](ClO4)(3) 2 and Cis[Co(trien)(4AMP)(C12H25NH2)](ClO4)(3) 3 (en: ethylenediamine, trien: triethylenetetramine, 4CNP: 4-cyanopyridine, 4AMP: 4-aminopyridine, C12H25NH2: dodecylamine) have been investigated by Fe2+ ion in liposome vesicles (DPPC) and ionic liquids medium at different temperatures under pseudo first order conditions using an excess of the reductant. In the presence of ionic liquid medium the second order rate constant for this electron transfer reaction was found to increase with increasing concentration of ionic liquids. Below the phase transition temperature of DPPC, the rate decreased with increasing concentration of DPPC, while above the phase transition temperature the rate increased with increasing concentration of DPPC for the same complexes has also been studied. Experimentally the reactions were found to be second order and the electron transfer postulated as outer sphere. The results have been discussed in terms of increased hydrophobic effect, self aggregation and the presence of pyridine ligand containing 4-amino and 4-cyano substituent. Crown Copyright (C) 2014 Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 89-00-9, in my other articles. Name: Pyridine-2,3-dicarboxylic acid.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry, like all the natural sciences, Product Details of 89-00-9, begins with the direct observation of nature¡ª in this case, of matter.89-00-9, Name is Pyridine-2,3-dicarboxylic acid, SMILES is O=C(C1=NC=CC=C1C(O)=O)O, belongs to pyridine-derivatives compound. In a document, author is Wan, Yuejuan, introduce the new discover.

Highly efficient photocatalytic hydrogen evolution based on conjugated molecular micro/nano-crystalline sheets

A novel conjugated organic molecule was constructed from an electron-donating unit (electron-donating benzo[1,2-b:5,4-b ‘]dithiophene) and electron-withdrawing groups (cyano and pyridine) and fabricated into sheet-shaped crystals. Intramolecular and intermolecular donor-acceptor interactions in crystals are beneficial to charge separation. A long-range ordered stacking mode through strong intermolecular interactions is conducive to electron migration (mu(e) = 0.25 cm(2) V-1 s(-1)) from the bulk to the surface of crystals and suppressing exciton recombination. The rugged surface and semitransparent feature of micro/nano-sheets improve the light capture and utilization efficiency of the photocatalyst. The high-crystallinity micro/nano-sheets exhibit a superior hydrogen evolution rate of 8143 mu mol g(-1) h(-1), which is far beyond that of most reported organic conjugated molecular photocatalysts. Such an organic conjugated compound with a definite molecular structure offers a new prototype for further developing high-performance photocatalysts towards solar-to-chemical energy conversion.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 89-00-9. Product Details of 89-00-9.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem