Category: 89076-64-2

El-Assal, Mona Ibrahim published the artcileNano-sponge novel drug delivery system as carrier of anti-hypertensive drug, Computed Properties of 89076-64-2, the publication is International Journal of Pharmacy and Pharmaceutical Sciences (2019), 11(10), 47-63, database is CAplus.

The study was designed to prepare Nano-sponge formulation loaded with nifedipine. Studying parameters which affecting the formulas in addition to pharmacokinetics and toxicity tests. Nine Nano-sponge formulations were prepared by the solvent evaporation technique. Different ratios of polymer ethylcellulose, COpolymers β-cyclodextrin and hydroxypropyl β-cyclodextrin in addition to solubilizing agent polyvinyl alc. were used. Thermal anal., X-ray powder diffraction (XRPD), shape and surface morphol., particle size, %production yield, %porosity, % swelling, and % drug entrapment efficiency of Nano-sponge were examined Release kinetic also studied beside comparison of pharmacokinetic parameters of the optimum choice formula and marketed one in addition to Toxicol. consideration. Particle size in the range of 119.1 nm to 529 nm which were increased due to the increase in the concentration of polymer to the drug. Nano-sponge revealed porous, spherical nature. Increased in the drug/polymer molar ratios (1:1 to 1:3) may increase their % production yield ranged from 62.1% to 92.4%. The drug content of different formulations was in the range of 77.9% to 94.7%, and entrapment efficiency was in the range of 82.72 % to 96.63%. Drug released in controlled sustained pattern and followed Higuchi, s diffusion mechanism. Pharmacokinetic parameters of optimized formula showed significant higher maximum plasma drug concentration, area under plasma concentration-time curve, volume of distribution and mean residence time. Nano-sponge loaded drug proved biol. safety at low concentrations Nano-sponge drug delivery system has showed small Nano size, porous with controlled drug release and significant-high plasma drug concentration that improved solubility, drug bioavailability and proved safety.

International Journal of Pharmacy and Pharmaceutical Sciences published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Computed Properties of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Asahara, Haruyasu published the artcileSubstituent Diversity-directed Synthesis of Nitropyridines and Nitroanilines by Three-component Ring Transformation, Quality Control of 89076-64-2, the publication is Procedia Engineering (2017), 1046-1057, database is CAplus.

A novel method for synthesis of various kinds of nitroarenes by using a three-component ring transformation (TCRT) of dinitropyridone with ketones in the presence of ammonium acetate as nitrogen source is developed. This method requires only simple manipulations and mild reaction conditions. Furthermore, the modification of obtained nitropyridine or nitroaniline frameworks can be easily obtained only changing a com. available substrates.

Procedia Engineering published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Quality Control of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Xing published the artcileNewly-generated Al(OH)₃-supported Pd nanoparticles-catalyzed Stille and Kumada coupling reactions of diazonium salts, (Het)aryl chlorides, Quality Control of 89076-64-2, the publication is Tetrahedron (2016), 72(1), 69-75, database is CAplus.

A ligand-free Pd/Al(OH)₃ nano-catalyst which is prepared by one-pot three-component method using Pd(PPh₃)₄, tetra (ethylene glycol), and aluminum tri-sec-butoxide exhibits excellent catalytic activity in Stille cross-couplings of (Het)aryl chlorides, arenediazonium tetrafluoroborate salts with phenyltributylstannane, resp., and Kumada couplings of (Het)aryl chlorides with various Grignard reagents. More importantly, these two processes show excellent functional group compatibility with moderate to good yields and they are also versatile with respect to not only (Het)aryl chlorides, but also diazonium salts, and heteroaryl Grignard reagents. The nano-catalyst could also be recycled and reused 5 times without loss of activity and decrease of yield.

Tetrahedron published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Quality Control of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Yu published the artcileA new tetraphosphine and its application in Pd-catalyzed Suzuki cross-coupling reaction, Recommanded Product: 5-Nitro-2-phenylpyridine, the publication is Youji Huaxue (2012), 32(4), 790-793, database is CAplus.

A new tetraphosphine, N,N,N’,N’-tetra(diphenylphosphinomethyl)-cyclohexane-1,2-diamine has been designed and synthesized from the com. available cyclohexane-1,2-diamine as starting material. This tetraphosphine in combination with [Pd(η³-C₃H₅)Cl]₂ is a very efficient catalyst for Suzuki cross-coupling reaction. Various aryl and heteroaryl chlorides or bromides could be successfully transformed to the desired products in up to 99% yield with 0.1 mol% catalyst loading.

Youji Huaxue published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C7H7ClN2S, Recommanded Product: 5-Nitro-2-phenylpyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Novak, Michael published the artcileNitrenium ions from food-derived heterocyclic arylamine mutagens, Name: 5-Nitro-2-phenylpyridine, the publication is Journal of the American Chemical Society (1998), 120(7), 1643-1644, database is CAplus.

The pivalic acid esters I (X = N, Y = CH, R = H, Me; X = CH, Y = N, R = H), models for the ultimate mutagenic and carcinogenic metabolites of heterocyclic arylamines, undergo spontaneous uncatalyzed hydrolysis under physiol. pH conditions, but become unreactive under acidic conditions in which the pyridyl N atom is protonated. Kinetic comparisons with the biphenyl ester I (X = Y = CH, R = H) show that the limiting hydrolysis rate constant, k₀, is reduced by substitution of an N atom for a C atom by ∼10⁴ for an ortho substitution and ∼30 for a meta substitution. The hydrolysis rates of these esters are insensitive to added N₃^–, but this nucleophile has considerable effect on reaction products. These results are consistent with a mechanism in which rate-limiting N-O bond heterolysis yields a nitrenium ion that is competitively trapped by solvent and N₃^–. The selectivity ratios, k_az/k_s, for the corresponding ions II (X ≠ Y) are ∼10-300-fold smaller than k_az/k_s for the 4-biphenylylnitrenium ion, II (X = Y = CH).

Journal of the American Chemical Society published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Name: 5-Nitro-2-phenylpyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

El-Assal, Mona Ibrahim published the artcileNano-sponge novel drug delivery system as carrier of anti-hypertensive drug, Computed Properties of 89076-64-2, the publication is International Journal of Pharmacy and Pharmaceutical Sciences (2019), 11(10), 47-63, database is CAplus.

The study was designed to prepare Nano-sponge formulation loaded with nifedipine. Studying parameters which affecting the formulas in addition to pharmacokinetics and toxicity tests. Nine Nano-sponge formulations were prepared by the solvent evaporation technique. Different ratios of polymer ethylcellulose, COpolymers β-cyclodextrin and hydroxypropyl β-cyclodextrin in addition to solubilizing agent polyvinyl alc. were used. Thermal anal., X-ray powder diffraction (XRPD), shape and surface morphol., particle size, %production yield, %porosity, % swelling, and % drug entrapment efficiency of Nano-sponge were examined Release kinetic also studied beside comparison of pharmacokinetic parameters of the optimum choice formula and marketed one in addition to Toxicol. consideration. Particle size in the range of 119.1 nm to 529 nm which were increased due to the increase in the concentration of polymer to the drug. Nano-sponge revealed porous, spherical nature. Increased in the drug/polymer molar ratios (1:1 to 1:3) may increase their % production yield ranged from 62.1% to 92.4%. The drug content of different formulations was in the range of 77.9% to 94.7%, and entrapment efficiency was in the range of 82.72 % to 96.63%. Drug released in controlled sustained pattern and followed Higuchi, s diffusion mechanism. Pharmacokinetic parameters of optimized formula showed significant higher maximum plasma drug concentration, area under plasma concentration-time curve, volume of distribution and mean residence time. Nano-sponge loaded drug proved biol. safety at low concentrations Nano-sponge drug delivery system has showed small Nano size, porous with controlled drug release and significant-high plasma drug concentration that improved solubility, drug bioavailability and proved safety.

International Journal of Pharmacy and Pharmaceutical Sciences published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Computed Properties of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Asahara, Haruyasu published the artcileSubstituent Diversity-directed Synthesis of Nitropyridines and Nitroanilines by Three-component Ring Transformation, Quality Control of 89076-64-2, the publication is Procedia Engineering (2017), 1046-1057, database is CAplus.

A novel method for synthesis of various kinds of nitroarenes by using a three-component ring transformation (TCRT) of dinitropyridone with ketones in the presence of ammonium acetate as nitrogen source is developed. This method requires only simple manipulations and mild reaction conditions. Furthermore, the modification of obtained nitropyridine or nitroaniline frameworks can be easily obtained only changing a com. available substrates.

Procedia Engineering published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Quality Control of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Xing published the artcileNewly-generated Al(OH)₃-supported Pd nanoparticles-catalyzed Stille and Kumada coupling reactions of diazonium salts, (Het)aryl chlorides, Quality Control of 89076-64-2, the publication is Tetrahedron (2016), 72(1), 69-75, database is CAplus.

A ligand-free Pd/Al(OH)₃ nano-catalyst which is prepared by one-pot three-component method using Pd(PPh₃)₄, tetra (ethylene glycol), and aluminum tri-sec-butoxide exhibits excellent catalytic activity in Stille cross-couplings of (Het)aryl chlorides, arenediazonium tetrafluoroborate salts with phenyltributylstannane, resp., and Kumada couplings of (Het)aryl chlorides with various Grignard reagents. More importantly, these two processes show excellent functional group compatibility with moderate to good yields and they are also versatile with respect to not only (Het)aryl chlorides, but also diazonium salts, and heteroaryl Grignard reagents. The nano-catalyst could also be recycled and reused 5 times without loss of activity and decrease of yield.

Tetrahedron published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Quality Control of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Yu published the artcileA new tetraphosphine and its application in Pd-catalyzed Suzuki cross-coupling reaction, Recommanded Product: 5-Nitro-2-phenylpyridine, the publication is Youji Huaxue (2012), 32(4), 790-793, database is CAplus.

A new tetraphosphine, N,N,N’,N’-tetra(diphenylphosphinomethyl)-cyclohexane-1,2-diamine has been designed and synthesized from the com. available cyclohexane-1,2-diamine as starting material. This tetraphosphine in combination with [Pd(η³-C₃H₅)Cl]₂ is a very efficient catalyst for Suzuki cross-coupling reaction. Various aryl and heteroaryl chlorides or bromides could be successfully transformed to the desired products in up to 99% yield with 0.1 mol% catalyst loading.

Youji Huaxue published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C7H7ClN2S, Recommanded Product: 5-Nitro-2-phenylpyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Novak, Michael published the artcileNitrenium ions from food-derived heterocyclic arylamine mutagens, Name: 5-Nitro-2-phenylpyridine, the publication is Journal of the American Chemical Society (1998), 120(7), 1643-1644, database is CAplus.

The pivalic acid esters I (X = N, Y = CH, R = H, Me; X = CH, Y = N, R = H), models for the ultimate mutagenic and carcinogenic metabolites of heterocyclic arylamines, undergo spontaneous uncatalyzed hydrolysis under physiol. pH conditions, but become unreactive under acidic conditions in which the pyridyl N atom is protonated. Kinetic comparisons with the biphenyl ester I (X = Y = CH, R = H) show that the limiting hydrolysis rate constant, k₀, is reduced by substitution of an N atom for a C atom by ∼10⁴ for an ortho substitution and ∼30 for a meta substitution. The hydrolysis rates of these esters are insensitive to added N₃^–, but this nucleophile has considerable effect on reaction products. These results are consistent with a mechanism in which rate-limiting N-O bond heterolysis yields a nitrenium ion that is competitively trapped by solvent and N₃^–. The selectivity ratios, k_az/k_s, for the corresponding ions II (X ≠ Y) are ∼10-300-fold smaller than k_az/k_s for the 4-biphenylylnitrenium ion, II (X = Y = CH).

Journal of the American Chemical Society published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Name: 5-Nitro-2-phenylpyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem