Category: 89076-64-2

Guo, Peng-Fei published the artcileC-H Arylation of Pyridines: High Regioselectivity as a Consequence of the Electronic Character of C-H Bonds and Heteroarene Ring, HPLC of Formula: 89076-64-2, the publication is Journal of the American Chemical Society (2011), 133(41), 16338-16341, database is CAplus and MEDLINE.

A new catalytic protocol for highly selective C-H arylation of pyridines containing common and synthetically versatile electron-withdrawing substituents (NO₂, CN, F and Cl) is reported. The new protocol expands the scope of catalytic azine functionalization as the excellent regioselectivity at the 3- and 4-positions well complements the existing methods for C-H arylation and Ir-catalyzed borylation, as well as classical functionalization of pyridines. Another important feature of the new method is its flexibility to adapt to challenging substrates by a simple modification of the carboxylic acid ligand or the use of silver salts. The regioselectivity can be rationalized on the basis of the key electronic effects (repulsion between the nitrogen lone pair and polarized C-Pd bond at C2-/C6-positions and acidity of the C-H bond) in combination with steric effects (sensitivity to bulky substituents).

Journal of the American Chemical Society published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, HPLC of Formula: 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Quan, Zheng-Jun published the artcilePalladium(II) catalyzed Suzuki/Sonogashira cross-coupling reactions of sulfonates: an efficient approach to C2-functionalized pyrimidines and pyridines, Synthetic Route of 89076-64-2, the publication is European Journal of Organic Chemistry (2013), 2013(31), 7175-7183, database is CAplus.

Pyrimidin-2-yl sulfonates, as a reaction partner, can be easily prepared from inexpensive com. materials and are efficiently cross-coupled with arylboronic acids and terminal alkynes by using Pd(OAc)₂-catalyzed Suzuki and Sonogashira reactions. A wide array of C2-functionalized pyrimidines have been prepared in good to excellent yields. 2-Arylpyridines and 2-(oct-1-ynyl)pyridine were also synthesized.

European Journal of Organic Chemistry published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Synthetic Route of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Metin, Oender published the artcileNi/Pd core/shell nanoparticles supported on graphene as a highly active and reusable catalyst for Suzuki-Miyaura cross-coupling reaction, Product Details of C11H8N2O2, the publication is Nano Research (2013), 6(1), 10-18, database is CAplus.

Monodisperse Ni/Pd core/shell nanoparticles (NPs) have been synthesized by sequential reduction of nickel(II) acetate and palladium(II) bromide in oleylamine (OAm) and trioctylphosphine (TOP). The Ni/Pd NPs have a narrow size distribution with a mean particle size of 10 nm and a standard deviation of 5% with respect to the particle diameter Mechanistic studies showed that the presence of TOP was essential to control the reductive decomposition of Ni-TOP and Pd-TOP, and the formation of Ni/Pd core/shell NPs. Using the current synthetic protocol, the composition of the Ni/Pd within the core/shell structure can be readily tuned by simply controlling the initial molar ratio of the Ni and Pd salts. The as-synthesized Ni/Pd core/shell NPs were supported on graphene (G) and used as catalyst in Suzuki-Miyaura cross-coupling reactions. Among three different kinds of Ni/Pd NPs tested, the Ni/Pd (Ni/Pd = 3/2) NPs were found to be the most active catalyst for the Suzuki-Miyaura cross-coupling of arylboronic acids with aryl iodides, bromides and even chlorides in a dimethylformamide/water mixture by using K₂CO₃ as a base at 110 °C. The G-Ni/Pd was also stable and reusable, providing 98% conversion after the 5th catalytic run without showing any noticeable Ni/Pd composition change. The G-Ni/Pd structure reported in this paper combines both the efficiency of a homogeneous catalyst and the durability of a heterogeneous catalyst, and is promising catalyst candidate for various Pd-based catalytic applications.

Nano Research published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Product Details of C11H8N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Nappi, Manuel published the artcileSelective Chemical Functionalization at N6-Methyladenosine Residues in DNA Enabled by Visible-Light-Mediated Photoredox Catalysis, Computed Properties of 89076-64-2, the publication is Journal of the American Chemical Society (2020), 142(51), 21484-21492, database is CAplus and MEDLINE.

Selective chem. that modifies the structure of DNA and RNA is essential to understanding the role of epigenetic modifications. We report a visible-light-activated photocatalytic process that introduces a covalent modification at a C(sp³)-H bond in the Me group of N6-Me deoxyadenosine and N6-Me adenosine, epigenetic modifications of emerging importance. A carefully orchestrated reaction combines reduction of a nitropyridine to form a nitrosopyridine spin-trapping reagent and an exquisitely selective tertiary amine-mediated hydrogen-atom abstraction at the N6-Me group to form an α-amino radical. Cross-coupling of the putative α-amino radical with nitrosopyridine leads to a stable conjugate, installing a label at N6-methyl-adenosine. We show that N6-Me deoxyadenosine-containing oligonucleotides can be enriched from complex mixtures, paving the way for applications to identify this modification in genomic DNA and RNA.

Journal of the American Chemical Society published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Computed Properties of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Liu, Chun published the artcileA General and Highly Efficient Method for the Construction of Aryl-Substituted N-Heteroarenes, Application In Synthesis of 89076-64-2, the publication is European Journal of Organic Chemistry (2010), 5548-5551, S5548/1-S5548/23, database is CAplus.

A general, simple and highly efficient method for the synthesis of heteroarylbenzenes has been developed via Pd(OAc)₂-catalyzed ligand-free and aerobic Suzuki coupling reaction of N-heteroaryl halides with arylboronic acids and the reaction is strongly dependent on the mol. structure of solvent.

European Journal of Organic Chemistry published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Application In Synthesis of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Liu, Lei published the artcilePalladium-catalyzed C-H trifluoromethylselenolation of arenes with [Me₄N][SeCF₃] and an oxidant, Application In Synthesis of 89076-64-2, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(66), 9238-9241, database is CAplus and MEDLINE.

Trifluoromethylselenolation of arenes with [Me₄N][SeCF₃] in the presence of an oxidant through Pd-catalyzed C(sp²)-H activation under the assistance of a directing group is established for the first time. The reaction tolerates different directing groups and a variety of functional groups, enabling selective installation of a SeCF₃ moiety onto the ortho positions of arenes. Mechanistic studies revealed that the CF₃SeSeCF₃ intermediate in situ generated from oxidation of [Me₄N][SeCF₃] might be the real SeCF₃ reagent in the reaction.

Chemical Communications (Cambridge, United Kingdom) published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Application In Synthesis of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Georgescu, Florentina C. published the artcilePyrimidinium ylides. V. Reactions of some 4-phenylpyrimidinium monosubstituted-carbanion ylides with nitromethane, Application of 5-Nitro-2-phenylpyridine, the publication is Revue Roumaine de Chimie (1983), 28(6), 653-7, database is CAplus.

Ylides I (R = Ph, O₂NC₆H₄, BrC₆H₄, anisyl, OEt) were treated with MeNO₂ and base to yield a pyridine II. I (R = Ph) (obtained from 4-phenyl-1-phenacylpyrimidinium bromide and base) was treated with Na₂CO₃ to give II.

Revue Roumaine de Chimie published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Application of 5-Nitro-2-phenylpyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Petiot, Pauline published the artcilePalladium-catalyzed cross-coupling reaction of functionalized aryl- and hetero-arylbismuthanes with 2-halo(or 2-triflyl)-azines and -diazines, Synthetic Route of 89076-64-2, the publication is European Journal of Organic Chemistry (2013), 2013(24), 5282-5289, database is CAplus.

The palladium-catalyzed cross-coupling of highly functionalized organobismuthanes with 2-halo(or 2-triflyl)pyridines, -pyrimidines, -pyrazines, and -pyridazines is reported. The reaction tolerates numerous functional groups, including aldehydes. The synthesis of a shelf-stable (formylphenyl)bismuth reagent and its use in a cross-coupling reaction is also described.

European Journal of Organic Chemistry published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Synthetic Route of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Xitao published the artcileTransition-Metal-Free Decarboxylative Arylation of 2-Picolinic Acids with Arenes under Air Conditions, Recommanded Product: 5-Nitro-2-phenylpyridine, the publication is Organic Letters (2018), 20(22), 7095-7099, database is CAplus and MEDLINE.

A facile, transition-metal-free, and direct decarboxylative arylation of 2-picolinic acids with simple arenes is described. The oxidative decarboxylative arylation of 2-picolinic acids with arenes proceeds readily via N-chloro carbene intermediates to afford 2-arylpyridines in satisfactory to good yields under transition-metal-free conditions. This new type of decarboxylative arylation is operationally simple and scalable and exhibits high functional-group tolerance. Various synthetically useful functional groups, such as halogen atoms, methoxycarbonyl, and nitro, remain intact during the decarboxylative arylation of 2-picolinic acids.

Organic Letters published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C7H6FNO3, Recommanded Product: 5-Nitro-2-phenylpyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Tohda, Yasuo published the artcileNucleophilic reaction upon electron-deficient pyridone derivatives. X. One-pot synthesis of 3-nitropyridines by ring transformation of 1-methyl-3,5-dinitro-2-pyridone with ketones or aldehydes in the presence of ammonia, Application In Synthesis of 89076-64-2, the publication is Bulletin of the Chemical Society of Japan (1990), 63(10), 2820-7, database is CAplus.

The reaction of 1-methyl-3,5-dinitro-2-pyridone (I) with aldehydes, ketones, or enamines in the presence of NH₃ gave alkyl and/or aryl-substituted 3-nitropyridine derivatives Enamines derived from ketones gave better results than the ketones themselves; enamines derived from aldehydes did not react. I reacted as an equivalent of NaO₂N:C(CHO)₂. A mechanistic pathway was discussed.

Bulletin of the Chemical Society of Japan published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C15H15OP, Application In Synthesis of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem