Synthetic Route of 89182-17-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89182-17-2, name is 6-Chloro-3,4-pyridinediamine, molecular formula is C5H6ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Synthesis of (6-chloro-1H-imidazo[4,5-c]pyridin-2-yl)benzylamine A solution of benzylthioisocyanate (7.0 mL, 53.1 mmol) and 6-chloro-pyridine-3,4-diamine (7.6 g, 53.1 mmol) in CHCl3 (110 mL) was heated at 50 C for 12 h. After cooling to ambient temperature, the reaction mixture was treated with EDC (12.2 g, 63.7 mmol) and Et3N (8.9 mL, 63.7 mmol). The reaction mixture was then stirred at room temperature for additional 18 h. CHCl3 (110 mL) was added to the reaction mixture, followed by water (110 mL) and the organic phase was separated. The aqueous phase was re-extracted with CHCl3 (2 x 150 mL) and the combined organic layers were washed with brine (50 mL). The organic layers were dried over Na2SO4, then concentrated in vacuo and purified by column chromatography on silica gel (AcOEt ? 5% MeOH/AcOEt, then 90% DCM/MeOH) to give the product as a brown semi-solid. The solid was further purified by trituration with ice cold iPr2O ether to give the product as an off white solid, which was used without further purification (3.00 g, 22%). LC-MS: Rt = 2.31 min; [M+H]+ 259/261.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 89182-17-2, 6-Chloro-3,4-pyridinediamine.
Reference:
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.; Ullrich, Axel (Prof. Dr.); Falcenberg, Mathias (Dr.); EP2818472; (2014); A1;,
Pyridine – Wikipedia,
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