Category: 89284-11-7

Reference of 89284-11-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89284-11-7, name is 5,6-Dibromopyridin-2-amine, molecular formula is C5H4Br2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 5,6-dibromopyridin-2-amine (80 g, 318 mmol), ethynylbenzene (78 ml, 698 mmol), copper(I) iodide (1.51 g, 7.94 mmol), Dichlorobis(triphenylphosphine)- palladium(II) (5.79 g, 7.94 mmol) and triethylamine (110 ml, 794 mmol) is stirred under argon atmosphere in ACN (500 ml) with THF (250 ml) for 21 h at 50C. The mixture is diluted with water and extracted with DCM. The combined organic layers are dried over MgS04, concentrated in vacuo and the product purified by NP chromatography. Yield: 82 g (94%). HPLC-MS: M+H=273/275; tR=1.34 min (*Method_l).

According to the analysis of related databases, 89284-11-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; REISER, Ulrich; BADER, Gerd; SPEVAK, Walter; STEFFEN, Andreas; PARKES, Alastair L.; WO2013/127729; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 89284-11-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 89284-11-7, name is 5,6-Dibromopyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 5,6-dibromo-pyridin-2-ylamine (10 kg, 39.7 mol) A and methylcyclohexane (40 L) is heated to 65 C. At this temperature is added N,N- dimethylformamide dimethyl acetal (4.97 kg, 41.7 mol) over a period of 30 min rinsing with methylcyclohexane (10 L). The reaction mixture is heated to 100 C for 1 h or until the reaction is complete while removing 10 L of solvent under reduced pressure. Then, methylcyclohexane (20 L) is added and the mixture is cooled to about 60-55 C. Crystallization is initiated by addition of seeding crystals and the resulting suspension is cooled to 20 C over a period of 4 h and then stirred for additional 15 min at this temperature. The title product B is isolated by filtration, washed with methylcyclohexane (2 x 15 L) and dried under vacuum at 50 C. Yield 80 %. MS (ESI+) m/z = 306/308/310 [M+H]+.

According to the analysis of related databases, 89284-11-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; LU, Guanghua; HUCHLER, Guenther; KRUEGER, Thomas; PANGERL, Michael; SANTAGOSTINO, Marco; DESROSIERS, Jean-Nicolas; (71 pag.)WO2017/198734; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 89284-11-7 ,Some common heterocyclic compound, 89284-11-7, molecular formula is C5H4Br2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 5,6-dibromopyridin-2-amine (9.50 g, 37.71 mmol) in methanol (100 mL) was added NaOMe solution (30% in MeOH, 100 g, 555.55 mmol) at room temperature. The resulting mixture was stirred for 1 h at 120 C. When the reaction was done, it was quenched by the addition of phosphate buffer solution (200 mL, pH = 7). The solids precipitated out from the resulting mixture were collected by filtration and dried under reduced pressure to yield 5-bromo-6-methoxypyridin-2-amine as orange solid (5.40 g, 71 %). MS: m/z = 202.8 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89284-11-7, its application will become more common.

Reference:
Patent; MERCK PATENT GMBH; KARRA, Srinivasa R.; XIAO, YuFang; SHERER, Brian A.; (380 pag.)WO2019/79373; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 89284-11-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 89284-11-7, name is 5,6-Dibromopyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 5,6-dibromopyridin-2-amine (9.50 g, 37.71 mmol) in methanol (100 mL) was added NaOMe solution (30% in MeOH, 100 g, 555.55 mmol) at room temperature. The resulting mixture was stirred for 1 h at 120 C. When the reaction was done, it was quenched by the addition of phosphate buffer solution (200 mL, pH = 7). The solids precipitated out from the resulting mixture were collected by filtration and dried under reduced pressure to yield 5-bromo-6-methoxypyridin-2-amine as orange solid (5.40 g, 71 %). MS: m/z = 202.8 [M+H]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 89284-11-7, 5,6-Dibromopyridin-2-amine.

Reference:
Patent; MERCK PATENT GMBH; KARRA, Srinivasa R.; XIAO, YuFang; SHERER, Brian A.; (380 pag.)WO2019/79373; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem