Category: 89466-18-2

Application of 89466-18-2, Adding some certain compound to certain chemical reactions, such as: 89466-18-2, name is 6-Bromo-2-methoxypyridin-3-amine,molecular formula is C6H7BrN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89466-18-2.

Example Al 4 a) Preparation of intermediate 31A mixture of formic acid (12.8 ml, 340 mmol) and acetic acid anhydride (8.54 ml, (91 mmol) was stirred at r.t. for 40 min. Subsequently, a solution of 3-amino-6-bromo- 2-methoxy-pyridine (5 g, 24.6 mmol) in THF (30 ml) was added dropwise to the mixture. The resulting r.m. was stirred overnight at 60 0C, and was then cooled and poured into ice-water, resulting in the precipitation of a solid. The solid was filtered off, washed with water, and dried. Yield: 5.2 g of intermediate 31 (76 %).

According to the analysis of related databases, 89466-18-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC; BISCHOFF, Francois, Paul; GIJSEN, Henricus, Jacobus, Maria; PIETERS, Serge, Maria, Aloysius; MINNE, Garrett, Berlond; WO2010/145883; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89466-18-2, name is 6-Bromo-2-methoxypyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 6-Bromo-2-methoxypyridin-3-amine

At room temperature, 6-bromo-2-methoxypyridin-3-amine (12.00 g, 59.10 mmol),Acetic anhydride (48.67 g, 466.90 mmol) was terminated at 20 C for 1 h. The reaction solution was added with water (240 ml) and stirred for 1 h. A brown precipitate was precipitated, filtered with suction, and the filter cake was dried.The yield was 9.80 g of brown solid with a yield of 68%.

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Reference:
Patent; Jiangsu Weikaier Pharmaceutical Technology Co., Ltd.; Gong Yanchun; Meng Lei; Guo Qirun; Liu Yongqiang; (65 pag.)CN110642838; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89466-18-2, name is 6-Bromo-2-methoxypyridin-3-amine, the common compound, a new synthetic route is introduced below. SDS of cas: 89466-18-2

6-bromo-2-methoxy-3-amine (1.02g, WO2011068211 pamphlet) In acetonitrile (20mL) solution,At 0 , 37% aqueous solution of formaldehyde (1.22g)And the mixture was stirred for 10 minutes. The reaction mixture was cooled to room temperature, sodium triacetoxyborohydride (3.18g) was added,The reaction was stirred overnight at the same temperature.Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate,After filtered, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexaEmissions: ethyl acetate = 9: 1 ? 4: 1) was purified by,6-bromo-2-methoxy -N, N-dimethyl-3-amine and 6-bromo-2-methoxy -N- methyl-pyridin-3-amine 2 was obtained 1 mixture (475 mg).

The synthetic route of 89466-18-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAISHO PHARMACEUTICAL COMPANY LIMITED; NISSAN CHEMICAL INDUSTRIES LIMITED; KURODA, SHOICHI; USHIKI, YASUNOBU; KAWAGUCHI, TAKANORI; FUSEGI, KEIKO; BOHNO, MASAHIRO; IMAI, YUDAI; UNEUCHI, FUMITO; IWAKIRI, KANAKO; TANAKA, HIROAKI; BOHNO, AYAKO; CHONAN, TOMOMICHI; ITOH, SHIN; OTA, HIROFUMI; ISHIYAMA, SEISHI; OKADA, TAKUYA; SASAKO, SHIGETADA; MONMA, SOUICHI; NIWA, MARIE; OKADA, TAKUMI; (289 pag.)JP2015/231988; (2015); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 89466-18-2 ,Some common heterocyclic compound, 89466-18-2, molecular formula is C6H7BrN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Acetic anhydride (11.3 mL, 120 mmol) was added dropwise to formic acid (17.0 mL, 450 mmol) then stirred at room temperature for 24 minutes. The formic acid and acetic anhydride mixture was added to 6-bromo-2-methoxypyridin-3- amine (Y1) in 50 mL of THF via cannula. The reaction was stirred at room temperature for 30 minutes. An additional 10 mL of THF was used to aid the transfer. The reaction was stirred at room temperature for 2h. The reaction was quenched with 140 mL of ice cold water. This solution was then filtered leaving a white solid. The solid was rinsed with additional water, dried on the filter, then left under vacuum overnight to yield 5.04g (70%) of the formamide (Y2). 1H NMR (CDCI3 400 MHz) delta 8.45-8.43 (m, 2H), 7.61 (br s, 1 H), 7.08 (d, J = 8.0 Hz, 1 H), 4.03 (s, 3H). MS: M+1 = 231.0.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89466-18-2, its application will become more common.

Reference:
Patent; SCHERING CORPORATION; ZHU, Zhaoning; GREENLEE, William, J.; LI, Hongmei; VICAREL, Monica, L.; QIN, Jun; DHONDI, Pawan, Kumar; HUANG, Xianhai; PALANI, Anandan; LIU, Xiaoxiang; SUN, Zhong-Yue; JOSIEN, Hubert B.; XU, Ruo; COLE, David, James; BURNETT, Duane, A.; BENNETT, Chad, E.; MCCRACKEN, Troy, M.; MACCOSS, Malcolm; WO2010/56722; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem