Category: 89488-29-9

Adding a certain compound to certain chemical reactions, such as: 89488-29-9, 2-Bromo-4-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 89488-29-9, blongs to pyridine-derivatives compound. Computed Properties of C6H6BrNO

PdCI2(dppf) (0.065 g, 0.08 mmol, 0.05 eq) was added to a solution of compound 52h (0.6 g, 1.58 mmol, 1 eq), potassium acetate (0.31 g, 3.17 mmol, 2 eq) and bis(pinacolato)diboron (0.8 g, 3.17 mmol, 2 eq) in dioxane that was stirred under Ar at rt. The reaction mixture was refluxed for 16 h, cooled to rt and filtered through a plug of celite. The filter was rinsed with EtOAc and the filtrate was washed with water (20 ml) and brine (20 ml), dried over Na2S04 and concentrated. The pinacol boronate (0.7 g) thus obtained was dissolved in dioxane (25 ml). 2-bromo-4-methoxypyridine (0.265 g, 1.41 mmol), 10% aqueous K2C03 solution (3.5 ml) and finally tetrakis(triphenylphosphine)palladium(0) (0.07 g, 0.06 mmol) were added. The mixture was refluxed for 16 h, cooled to rt and filtered through a plug of celite. The filter was rinsed with EtOAc and the filtrate was washed with water (20 ml), brine (20 ml), dried over Na2S04 and concentrated. The remnant was purified by column chromatography [EtOAc/hexane = 1 :1 ]. White solid. Yield: 0.27 g. m/z: [M+H]+ = 406.8.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89488-29-9, its application will become more common.

Reference:
Patent; GRUeNENTHAL GMBH; KONETZKI, Ingo; JAKOB, Florian; WAGENER, Markus; WELBERS, Andre; HESSLINGER, Christian; (168 pag.)WO2017/108204; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 89488-29-9, 2-Bromo-4-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 89488-29-9, blongs to pyridine-derivatives compound. Computed Properties of C6H6BrNO

PdCI2(dppf) (0.065 g, 0.08 mmol, 0.05 eq) was added to a solution of compound 52h (0.6 g, 1.58 mmol, 1 eq), potassium acetate (0.31 g, 3.17 mmol, 2 eq) and bis(pinacolato)diboron (0.8 g, 3.17 mmol, 2 eq) in dioxane that was stirred under Ar at rt. The reaction mixture was refluxed for 16 h, cooled to rt and filtered through a plug of celite. The filter was rinsed with EtOAc and the filtrate was washed with water (20 ml) and brine (20 ml), dried over Na2S04 and concentrated. The pinacol boronate (0.7 g) thus obtained was dissolved in dioxane (25 ml). 2-bromo-4-methoxypyridine (0.265 g, 1.41 mmol), 10% aqueous K2C03 solution (3.5 ml) and finally tetrakis(triphenylphosphine)palladium(0) (0.07 g, 0.06 mmol) were added. The mixture was refluxed for 16 h, cooled to rt and filtered through a plug of celite. The filter was rinsed with EtOAc and the filtrate was washed with water (20 ml), brine (20 ml), dried over Na2S04 and concentrated. The remnant was purified by column chromatography [EtOAc/hexane = 1 :1 ]. White solid. Yield: 0.27 g. m/z: [M+H]+ = 406.8.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89488-29-9, its application will become more common.

Reference:
Patent; GRUeNENTHAL GMBH; KONETZKI, Ingo; JAKOB, Florian; WAGENER, Markus; WELBERS, Andre; HESSLINGER, Christian; (168 pag.)WO2017/108204; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 89488-29-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89488-29-9, name is 2-Bromo-4-methoxypyridine, molecular formula is C6H6BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation 55 To a suspension of 2-bromo-4-methoxypyridine (1.21 g), 4-chlorophenylboronic acid (1.21 g) and tetrakis(triphenylphosphine)-palladium (372 mg) in 1,2-dimethoxyethane (20 ml) was added 2M aqueous solution of sodium carbonate (7.74 ml). The mixture was stirred at 80 C. for 12 hours under a nitrogen atmosphere, then cooled to room temperature and diluted with ethyl acetate. The organic layer was separated, washed with water and brine and dried over sodium sulfate. The solvent was evaporated under reduced pressure. 2-Propanol was added to the residue. The precipitate was collected by filtration and dried under reduced pressure to give 4-(4-methoxypyridin-2-yl)-chlorobenzene (1.03 g). 1H-NMR (CDCl3): delta3.91(3H,s), 6.78(1H,dd,J=5.7 Hz,2.4 Hz), 7.19(1H,d,J=2.4 Hz), 7.42(2H,d,J=8.6 Hz), 7.90(2H,d,J=8.0 Hz), 8.51(1H,d,J=5.7 Hz)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 89488-29-9, 2-Bromo-4-methoxypyridine.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US6521643; (2003); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 89488-29-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 89488-29-9, name is 2-Bromo-4-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows.

A Straus flask equipped with a stirrer bar was charged with 2-bromopyridine (1.0 equiv.), 1-naphthylboronic acid (1.1 equiv),Pd(PPh3)4 (4 mol%), 2 M aq Na2CO3 (2.5 mL/mmol), toluene(3.8 mL/mmol), and ethanol (1.3 mL/mmol). The mixture wasdegassed by three freeze-pump-thaw cycles and then refluxedunder inert conditions overnight. The mixture was cooled to r.t.and extracted with EtOAc (3 ¡Á 20 mL). The organic phases werecombined, dried (MgSO4), and concentrated. The pure ligandwas obtained by flash column chromatography [silica gel,EtOAc-hexane (1:4)].Compound was isolated as viscous liquid that solidified uponstanding. Yield: 1.6 g (99%).

According to the analysis of related databases, 89488-29-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Njogu, Rachael E.N.; Fodran, Peter; Tian, Yuxi; Njenga, Lydia W.; Kariuki, David K.; Yusuf, Amir O.; Scheblykin, Ivan; Wendt, Ola F.; Wallentin, Carl-Johan; Synlett; vol. 30; 7; (2019); p. 792 – 798;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem