Category: 89488-30-2

Application of 89488-30-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.89488-30-2, name is 5-Bromo-3-methylpyridin-2(1H)-one, molecular formula is C6H6BrNO, molecular weight is 188.0219, as common compound, the synthetic route is as follows.

5-Bromo- 1 ,3-dimethyl- 1H-pyridin-2-one B-i To a suspension of 5-bromo-2-hydroxy-3-methyl pyridine Al (1.000 g; 5.053mmo 1) and potassium carbonate (1.397 g; 10.105 mmo 1) in DMF (5.000 ml) iscarefully added iodomethane (0.346 ml; 5.558 mmol). The reaction mixture is stirred overnight (1 6h) at room temperature. The reaction mixture is then quenched with 10% ammonia solution (10 ml) and 30 ml water is added. It is extracted with 3×50 ml EtOAc. The combined organic layer is dried with Na2SO4, filtered andconcentrated under reduced pressure to afford the product.Yield: 98% (1.0 g; 4.95 mmol)HPLC-MS: (M+H) = 202/204; tRet = 0.65 mm; method LCMS BAS1

Statistics shows that 89488-30-2 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-3-methylpyridin-2(1H)-one.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ENGELHARDT, Harald; MARTIN, Laetitia; SMETHURST, Christian; WO2015/22332; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 89488-30-2, 5-Bromo-3-methylpyridin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 89488-30-2, blongs to pyridine-derivatives compound. Recommanded Product: 89488-30-2

To a mixture of compound 4b2 (2 g, 10.6 mmol) and CH2CI2 (100 mL) is added Ag2CO3 (8.8 g, 31.9 mmol) and CH3I (7 mL, 112 mmol). The reaction mixture is stirred at room temperature overnight, then filtered through diatomaceous earth (Celite). The filtrate is concentrated under reduced pressure to give compound4b3.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,89488-30-2, 5-Bromo-3-methylpyridin-2(1H)-one, and friends who are interested can also refer to it.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GmbH & CO KG; WO2008/67644; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 89488-30-2, Adding some certain compound to certain chemical reactions, such as: 89488-30-2, name is 5-Bromo-3-methylpyridin-2(1H)-one,molecular formula is C6H6BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89488-30-2.

Example 14i 5-Bromo-2-(tert-butyldimethylsilyloxy)-3-methylpyridine Triethylamine (29.4 mL, 211 mmol) was added to a suspension of 5-bromo-2-hydroxy-3-methylpyridine (15.9 g, 84.6 mmol) and tert-butyldimethylchlorosilane (15.29 g, 101 mmol) in CH2Cl2 (280 mL). After 4 h at r.t. water was added and the phases were separated. The organic phase was washed once with water, dried (Na2SO4), filtered, concentrated and co-evaporated twice with toluene to give the title compound (25.8 g, quant. yield): 1H NMR (400 MHz, DMSO-d6) delta ppm 0.26-0.29 (m, 6H), 0.96 (s, 9H), 2.12 (s, 3H), 7.80 (dd, 1H), 8.03 (d, 1H); MS (ES+) m/z 302, 304 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 89488-30-2, 5-Bromo-3-methylpyridin-2(1H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; US2012/165346; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 89488-30-2, name is 5-Bromo-3-methylpyridin-2(1H)-one. A new synthetic method of this compound is introduced below., Recommanded Product: 5-Bromo-3-methylpyridin-2(1H)-one

Example 509 5-{1-[2-(Difluoromethoxy)benzyl]-2-methyl-1H-benzimidazol-6-yl}-3-methylpyridin-2(1H)-one To Intermediate 57 (140 mg, 0.34 mmol) were added 5-bromo-3-methylpyridin-2-ol (76 mg, 0.41 mmol), Pd(PPh3)4 (20 mg, 0.016 mmol), 2M aqueous Na2CO3 solution (2 mL) and 1,4-dioxane (10 mL). The reaction mixture was stirred at 105 C. for 4 h. Further Pd(PPh3)4 (20 mg, 0.016 mmol) and Na2CO3 solution (1 mL) were added and the reaction mixture was stirred at 105 C. overnight. The reaction mixture was cooled to ambient temperature, diluted with water (1 mL) and extracted with ethyl acetate (2*20 mL). The combined organic layers were concentrated in vacuo and the crude residue was purified by silica flash column chromatography (0-10% MeOH/DCM) and then by preparative HPLC to yield, after freeze-drying, the title compound (3 mg, 2%) as a white solid. deltaH (d6-DMSO) 11.59-11.25 (1H, br s), 7.72 (1H, d, J 1.4 Hz), 7.63-7.49 (3H, m), 7.40-7.33 (3H, m), 7.26 (1H, d, J 7.6 Hz), 7.16-7.11 (1H, m), 6.68-6.65 (1H, m), 5.52 (2H, s), 2.45 (3H, s), 2.00 (3H, s). LCMS (pH 3) 396.8, MH+, RT 1.33 minutes, 100% UV. LCMS (pH 10) 396.8, MH+, RT 1.66 minutes, 100% UV.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 89488-30-2, 5-Bromo-3-methylpyridin-2(1H)-one.

Reference:
Patent; Brookings, Daniel Christopher; Calmiano, Mark Daniel; Gallimore, Ellen Olivia; Horsley, Helen Tracey; Hutchings, Martin Clive; Johnson, James Andrew; Kroeplien, Boris; Lecomte, Fabien Claude; Lowe, Martin Alexander; Norman, Timothy John; Porter, John Robert; Quincey, Joanna Rachel; Reuberson, James Thomas; Selby, Matthew Duncan; Shaw, Michael Alan; Zhu, Zhaoning; Foley, Anne Marie; US2015/152065; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 89488-30-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 89488-30-2, name is 5-Bromo-3-methylpyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 1-(1-benzyl-5-methyl-1H-pyrazol-4-yl)-2-bromoethan- 1-one (590 mg), 5-bromo-3-methylpyridin-2-ol (378 mg), K2CO3 (555.60 mg, 4.02 mmol) and DMSO (10 mL) was stirred at room temperature overnight. The mixture was quenched with water and the resulting solid was collected by filtration and washed with water. The solid was recrystallized from DMSO/water to give the target compound (460 mg) as a solid. (1380) [00534] 1H NMR (500 MHz, DMSO-d6): ^ 8.29 (s, 1H), 7.83 (dd, J = 2.7, 0.9 Hz, 1H), 7.53 (dq, J = 2.3, 1.1 Hz, 1H), 7.40-7.35 (m, 2H), 7.34-7.29 (m, 1H), 7.19-7.15 (m, 2H), 5.43 (s, 2H), 5.22 (s, 2H), 2.50 (s, 3H), 2.01 (t, J = 0.9 Hz, 3H).

According to the analysis of related databases, 89488-30-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; HLA, Timothy; JILISHITZ, Irina; MEINKE, Peter; STAMFORD, Andrew; FOLEY, Michael; SATO, Ayumu; WADA, Yasufimi; FUKASE, Yoshiyuki; KINA, Asato; TAKAHAGI, Hiroki; IGAWA, Hideyuki; POLVINO, William J.; (0 pag.)WO2019/173790; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 89488-30-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89488-30-2, name is 5-Bromo-3-methylpyridin-2(1H)-one, molecular formula is C6H6BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 11B 5-bromo-2-chloro-3-methylpyridine The product from Example 11A (4.1 g, 221.8 mmol) in DMF (40 mL) was treated with phosphorus oxychloride (10 g, 65.4 mmol) dropwise at 0 C. After heating at 120 C. for 2 hours, the mixture was cooled and poured onto ice/water. The mixture was made basic with NH4OH, filtered, and the filtercake washed with ice water. The obtained solid was dissolved in dichloromethane (100 mL), washed with brine, and dried (MgSO4). The dried solution was filtered through a pad of silica using dichloromethane and the filtrate concentrated to provide the title compound as a white solid (3.48 g, 78% yield): 1H NMR (CDCl3, 300 MHz) delta 2.39 (s, 3H), 7.70 (m, 1H), 8.31, d, J=3 Hz, 1H).

According to the analysis of related databases, 89488-30-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Schrimpf, Michael R.; Tietje, Karin R.; Toupence, Richard B.; Ji, Jianguo; Basha, Anwer; Bunnelle, William H.; Daanen, Jerome F.; Pace, Jennifer M.; Sippy, Kevin B.; US2002/19388; (2002); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 89488-30-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 89488-30-2, name is 5-Bromo-3-methylpyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 1-(1-benzyl-5-methyl-1H-pyrazol-4-yl)-2-bromoethan- 1-one (590 mg), 5-bromo-3-methylpyridin-2-ol (378 mg), K2CO3 (555.60 mg, 4.02 mmol) and DMSO (10 mL) was stirred at room temperature overnight. The mixture was quenched with water and the resulting solid was collected by filtration and washed with water. The solid was recrystallized from DMSO/water to give the target compound (460 mg) as a solid. (1380) [00534] 1H NMR (500 MHz, DMSO-d6): ^ 8.29 (s, 1H), 7.83 (dd, J = 2.7, 0.9 Hz, 1H), 7.53 (dq, J = 2.3, 1.1 Hz, 1H), 7.40-7.35 (m, 2H), 7.34-7.29 (m, 1H), 7.19-7.15 (m, 2H), 5.43 (s, 2H), 5.22 (s, 2H), 2.50 (s, 3H), 2.01 (t, J = 0.9 Hz, 3H).

According to the analysis of related databases, 89488-30-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; HLA, Timothy; JILISHITZ, Irina; MEINKE, Peter; STAMFORD, Andrew; FOLEY, Michael; SATO, Ayumu; WADA, Yasufimi; FUKASE, Yoshiyuki; KINA, Asato; TAKAHAGI, Hiroki; IGAWA, Hideyuki; POLVINO, William J.; (0 pag.)WO2019/173790; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 89488-30-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89488-30-2, name is 5-Bromo-3-methylpyridin-2(1H)-one, molecular formula is C6H6BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 11B 5-bromo-2-chloro-3-methylpyridine The product from Example 11A (4.1 g, 221.8 mmol) in DMF (40 mL) was treated with phosphorus oxychloride (10 g, 65.4 mmol) dropwise at 0 C. After heating at 120 C. for 2 hours, the mixture was cooled and poured onto ice/water. The mixture was made basic with NH4OH, filtered, and the filtercake washed with ice water. The obtained solid was dissolved in dichloromethane (100 mL), washed with brine, and dried (MgSO4). The dried solution was filtered through a pad of silica using dichloromethane and the filtrate concentrated to provide the title compound as a white solid (3.48 g, 78% yield): 1H NMR (CDCl3, 300 MHz) delta 2.39 (s, 3H), 7.70 (m, 1H), 8.31, d, J=3 Hz, 1H).

According to the analysis of related databases, 89488-30-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Schrimpf, Michael R.; Tietje, Karin R.; Toupence, Richard B.; Ji, Jianguo; Basha, Anwer; Bunnelle, William H.; Daanen, Jerome F.; Pace, Jennifer M.; Sippy, Kevin B.; US2002/19388; (2002); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 89488-30-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.89488-30-2, name is 5-Bromo-3-methylpyridin-2(1H)-one, molecular formula is C6H6BrNO, molecular weight is 188.0219, as common compound, the synthetic route is as follows.

(0592) To a solution of 5-bromo-2-hydroxy-3-methyl pyridine (376 mg, 2.00 mmol) in toluene (15 mL) were added Ag2C03 (827 mg, 3.00 mmol) and benzyl bromide ( 13 mg, 3.00 mmol), and the mixture was stirred at 40 C for 2 h. The insoluble material was filtered, and the filtrate was concentrated in vacuo. The residue was purified by silica gel column (eluent: dichloromethane/ methanol, 0-20%) to yield light yellow solid (436 mg, 78%). 1H NMR (400 MHz, chloroform-c ) delta 8.08 – 8.02 (m, 1H), 7.51 (m, 1H), 7.49 – 7.41 (m, 2H), 7.43- 7.28 (m, 3H), 5.38 (s, 2H), 2.22 (s, 3H).

Statistics shows that 89488-30-2 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-3-methylpyridin-2(1H)-one.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE; YIN, Hang Hubert; ZHANG, Shuting; HU, Zhenyi; (114 pag.)WO2019/89648; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 89488-30-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.89488-30-2, name is 5-Bromo-3-methylpyridin-2(1H)-one, molecular formula is C6H6BrNO, molecular weight is 188.0219, as common compound, the synthetic route is as follows.

(0592) To a solution of 5-bromo-2-hydroxy-3-methyl pyridine (376 mg, 2.00 mmol) in toluene (15 mL) were added Ag2C03 (827 mg, 3.00 mmol) and benzyl bromide ( 13 mg, 3.00 mmol), and the mixture was stirred at 40 C for 2 h. The insoluble material was filtered, and the filtrate was concentrated in vacuo. The residue was purified by silica gel column (eluent: dichloromethane/ methanol, 0-20%) to yield light yellow solid (436 mg, 78%). 1H NMR (400 MHz, chloroform-c ) delta 8.08 – 8.02 (m, 1H), 7.51 (m, 1H), 7.49 – 7.41 (m, 2H), 7.43- 7.28 (m, 3H), 5.38 (s, 2H), 2.22 (s, 3H).

Statistics shows that 89488-30-2 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-3-methylpyridin-2(1H)-one.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE; YIN, Hang Hubert; ZHANG, Shuting; HU, Zhenyi; (114 pag.)WO2019/89648; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem