Category: 89510-90-7

Electric Literature of 89510-90-7 , The common heterocyclic compound, 89510-90-7, name is 2-Chloro-5-fluoro-4-pyridinamine, molecular formula is C5H4ClFN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 2-chloro-5-fluoropyridin-4-amine (900mg, 6.41 mmol, 1 eq) in Morpholine (9ml_) was irradiated under microwave at 180C for 90min in 30ml_ vial. TLC analysis indicated formation of polar spot. Then, the reaction mixture was cooled to RT and poured on ice-waterto give a off white precipitate; which was purified by column chromatography (Silica gel 100-200mesh) using 40% EtOAc in petroleum ether as an eluent to give 5-fluoro-2- morpholinopyridin-4-amine (720mg, 57.14% yield) as an off-white solid. LC- MS: m/z 198.0 (M+ H).

The synthetic route of 89510-90-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; ISAAC, Methvin; CHAU, Anh My; MAMAI, Ahmed; WATSON, Iain; PODA, Gennady; SUBRAMANIAN, Pandiaraju; WILSON, Brian; UEHLING, David; PRAKESCH, Michael; JOSEPH, Babu; MORIN, Justin-Alexander; (441 pag.)WO2019/153080; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 89510-90-7, 2-Chloro-5-fluoro-4-pyridinamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 89510-90-7, blongs to pyridine-derivatives compound. Recommanded Product: 89510-90-7

Intermediate 11A was synthesized employing the procedure described for Example 7C (Scheme 7). The crude compound was purified by silica gel column chromatography eluted with 55% Ethylacetate in Hexane to afford hA (120 mg, 0.112 mmol, 19.3 % yield) as a off white solid. LCMS: m/z 622.7(M+H); rt 1.60 mm;10 Conditions B.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,89510-90-7, 2-Chloro-5-fluoro-4-pyridinamine, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; HARIKRISHNAN, Lalgudi S.; FINK, Brian E.; BORZILLERI, Robert M.; TONUKUNURU, Gopikishan; WARRIER, Jayakumar Sankara; (111 pag.)WO2017/19757; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem