Application of 898746-35-5, Adding some certain compound to certain chemical reactions, such as: 898746-35-5, name is 1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid,molecular formula is C8H6N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 898746-35-5.
To a solution of lH-pyrrolo[2,3-b]pyridine-6-carboxylic acid (1 g, 6.17 mmol, 1 eq) in MeCN (10 mL) was added HOBt (1.67 g, 12.33 mmol, 2 eq), EDCI (2.36 g, 12.33 mmol, 2 eq), N- hydroxyacetamidine (913.77 mg, 12.33 mmol, 2 eq), and DIPEA (3.99 g, 30.84 mmol, 5.37 mL, 5 eq). The mixture was stirred at 30 C for 12 h. Then it was concentrated under reduced pressure to afford the title compound (1.5 g, crude) as white solid which was used directly without further purification.
According to the analysis of related databases, 898746-35-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SYROS PHARMACEUTICALS, INC.; MARINEAU, Jason J.; CHUAQUI, Claudio; CIBLAT, Stephane; KABRO, Anzhelika; PIRAS, Henri; WHITMORE, Kenneth Matthew; LUND, Kate-Lyn; (200 pag.)WO2019/143719; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem