Adding a certain compound to certain chemical reactions, such as: 89943-11-3, 5-Ethoxypyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 5-Ethoxypyridin-2-amine, blongs to pyridine-derivatives compound. Recommanded Product: 5-Ethoxypyridin-2-amine
A mixture of {1 -[4-(2-bromo-2-phenyl-acetyl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester [lnt-1 -A] (0.87 g, 2.0 mmol), 2-amino-5-ethoxypyridine (0.54 g, 3.9 mmol, 2 equiv) and powdered activated 3A sieves (10 g) in ethanol (7.3 mL) was heated for 5 h at the reflux temperature with monitoring by UPLC-MS. The resulting solution was separated between CH2CI2 (25 mL) and an saturated aqueous NaHCO3 solution (25 mL). The organic phase was washed with a saturated aqueous NaCI solution (25 mL), dried (Na2SO4 anh), and concentrated under reduced pressure. The remaining material was purified using MPLC (Biotage Isolera; 25 g SNAP cartridge: 100% hexane for 1 .5 min., gradient to 80% hexane / 20% EtOAc over 2.2 min., gradient to 70% hexane / 30% EtOAc over 10.6 min., 70% hexane / 30% EtOAc for 2.8 min., gradient to 65% hexane / 35% EtOAc over 2.2 min., 65% hexane / 35% EtOAc for 4.8 min.) to give {1 -[4-(6-ethoxy-3-phenyl-imidazo[1 ,2- a]pyridin-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester (0.26 g, 28%): UPLC-MS (Method 2): RT = 1 .58 min; m/z (rel intensity) 484 (100, (M+H)+).MS: m/z (rel intensity) 484 (100, (M+H)+).1 H-NMR (d6-DMSO): delta 1 .1 1 (br s, 3H), 1 .33 (br s, 6H), 1 .39 (t, J=6.9 Hz, 3H), 1 .77 (br s, 1 H), 1 .93-2.00 (m, 1 H), 2.31 -2.42 (m, 4H), 4.15 (q, J=7.1 Hz, 2H), 6.58 (dd, J=7.5, 2.6 Hz, 1 H), 7.03 (d, J=2.3 Hz, 1 H), 7.26 (d, J=8.3 Hz, 2H), 7.48 (d, J=7.2 Hz, 2H), 7.50-7.60 (m, 5H), 7.84 (br s, 1 H) ppm.
The synthetic route of 89943-11-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; INCE, Stuart; HAEGEBARTH, Andrea; POLITZ, Oliver; NEUHAUS, Roland; BOeMER, Ulf; SCOTT, William; WO2012/7345; (2012); A2;,
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