Category: 905273-87-2

Reference of 905273-87-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 905273-87-2 as follows.

The compound 49.2 (24.0 g, 100 mmol, 1.0 eq) was dissolved in diethyl ether (200 mL) and cooled to -75 C. N, N-Diisopropyl amine (72 mL, 500 mmol, 5 eq.) and n-BuLi (200 ml, 500 mmol, 5.0 eq.) were added dropwise to the reaction mixture at -78 C. Reaction was stirred for 15 minutes at -78 C., then DMF (12 ml, 150 mmol, 1.5 eq.) was added at -78 C. and reaction was stirred for 1 h. After completion of the reaction, mixture was poured into water, quenched with 10% citric acid and extracted with diethyl ether. Organic layers were combined, dried over Na2SO4 and concentrated under reduced pressure to obtain crude which is purified by column chromatography to furnish 49.3 (23.3 g, 86.8%). MS (ES): m/z 268.74 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,905273-87-2, its application will become more common.

Reference:
Patent; Nimbus Lakshmi, Inc.; Dahlgren, Markus; Greenwood, Jeremy Robert; Harriman, Geraldine C.; Kennedy-Smith, Joshua Jahmil; Masse, Craig E.; Romero, Donna L.; Shelley, Mee; Wester, Ronald T.; (131 pag.)US2016/251376; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 905273-87-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 905273-87-2 as follows.

The compound 49.2 (24.0 g, 100 mmol, 1.0 eq) was dissolved in diethyl ether (200 mL) and cooled to -75 C. N, N-Diisopropyl amine (72 mL, 500 mmol, 5 eq.) and n-BuLi (200 ml, 500 mmol, 5.0 eq.) were added dropwise to the reaction mixture at -78 C. Reaction was stirred for 15 minutes at -78 C., then DMF (12 ml, 150 mmol, 1.5 eq.) was added at -78 C. and reaction was stirred for 1 h. After completion of the reaction, mixture was poured into water, quenched with 10% citric acid and extracted with diethyl ether. Organic layers were combined, dried over Na2SO4 and concentrated under reduced pressure to obtain crude which is purified by column chromatography to furnish 49.3 (23.3 g, 86.8%). MS (ES): m/z 268.74 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,905273-87-2, its application will become more common.

Reference:
Patent; Nimbus Lakshmi, Inc.; Dahlgren, Markus; Greenwood, Jeremy Robert; Harriman, Geraldine C.; Kennedy-Smith, Joshua Jahmil; Masse, Craig E.; Romero, Donna L.; Shelley, Mee; Wester, Ronald T.; (131 pag.)US2016/251376; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 905273-87-2, name is 6-Chloro-N,N-diisopropylnicotinamide, molecular formula is C12H17ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyridine-derivatives

To a stirred solution of diisopropylamine (1 g, 9.88 mmol, 4.76 equiv) in ether (30 mL) at -50C maintained under nitrogen was added a 2.5 M solution of n-BuLi (5 mL) in hexanes dropwise The reaction mixture was stirred for 30 min a -50C then solid 6- chloro-N,N-bis(propan-2-yl)pyridine-3-carboxamide (500 mg, 2.08 mmol, 1.00 equiv) was added in a single portion. The resulting solution was stirred for 30 min at -50C DMF (1 mL) was then added dropwise with stirring. The reaction mixture was stirred at -50C for 3 h and then warmed to rt and stirred overnight. The reaction was quenched by the addition of 10% aqueous citric acid solution (30 mL) and then extracted with 2×50 mL of ether. The combined organic layers were dried over anhydrous sodium sulfate and concentrated under vacuum to give 0.5 g of crude 6-chloro-4-formyl-N,N-bis(propan-2-yl)pyridine-3-carboxamide as a yellow solid. LC/MS (Method G, ESI): RT= 1.40 min, m/z = 269.0 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 905273-87-2.

Reference:
Patent; GENENTECH,INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; BUCKMELTER, Alexandre J.; CLODFELTER, Kanl H.; DRAGOVICH, Peter; HAN, Bingsong; LIN, Jian; LIU, Xiongcai; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; YUEN, Po-Wai; ZAK, Mark; ZHANG, Yamin; ZHENG, Xiaozhang; ZHAO, Guiling; WO2013/127268; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem