Category: 905563-79-3

Application of 905563-79-3 ,Some common heterocyclic compound, 905563-79-3, molecular formula is C7H6ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(S)-N- [( 1 Z -(2-Chloro-4-methoxypyridin-3 -yDmethylidene] -2-methylpropane-2- sulfmamide (0640) To a solution of 2-chloro-4-methoxypyridine-3-carbaldehyde (15 g, 87.4 mmol) in THF (180 mL) at 0C were added sequentially 2-methylpropane-2-sulfinamide (11.72 g, 96.7 mmol), tripotassium phosphate (56.0 g, 264 mmol) and dipotassium hydrogen phosphate (46.0 g, 264 mmol). The cooling bath was removed and the resultant suspension was stirred at r.t. for 18 h. The reaction mixture was filtered through celite, – – (0641) washing through with EtOAc. The filtrate was diluted with EtOAc (250 mL) and washed with brine (200 mL), then dried over anhydrous sodium sulfate, filtered and evaporated in vacuo. The crude material was purified by flash column chromatography (Si02, 0-50% EtOAc in heptane) to afford the title compound (22.0 g, 94%) as a pale yellow solid. 5H (500 MHz, CDCls) 8.88 (s, 1H), 8.33 (d, J5.8 Hz, 1H), 6.88 (d, J 5.8 Hz, 1H), 3.96 (s, 3H), 1.29 (s, 9H). LCMS Method 1 (ES+) RT 1.51 minutes, 275/277 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,905563-79-3, its application will become more common.

Reference:
Patent; UCB BIOPHARMA SPRL; SANOFI; DELIGNY, Michael Louis Robert; HEER, Jag Paul; (86 pag.)WO2017/167993; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 905563-79-3 ,Some common heterocyclic compound, 905563-79-3, molecular formula is C7H6ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(S)-N- [( 1 Z -(2-Chloro-4-methoxypyridin-3 -yDmethylidene] -2-methylpropane-2- sulfmamide (0640) To a solution of 2-chloro-4-methoxypyridine-3-carbaldehyde (15 g, 87.4 mmol) in THF (180 mL) at 0C were added sequentially 2-methylpropane-2-sulfinamide (11.72 g, 96.7 mmol), tripotassium phosphate (56.0 g, 264 mmol) and dipotassium hydrogen phosphate (46.0 g, 264 mmol). The cooling bath was removed and the resultant suspension was stirred at r.t. for 18 h. The reaction mixture was filtered through celite, – – (0641) washing through with EtOAc. The filtrate was diluted with EtOAc (250 mL) and washed with brine (200 mL), then dried over anhydrous sodium sulfate, filtered and evaporated in vacuo. The crude material was purified by flash column chromatography (Si02, 0-50% EtOAc in heptane) to afford the title compound (22.0 g, 94%) as a pale yellow solid. 5H (500 MHz, CDCls) 8.88 (s, 1H), 8.33 (d, J5.8 Hz, 1H), 6.88 (d, J 5.8 Hz, 1H), 3.96 (s, 3H), 1.29 (s, 9H). LCMS Method 1 (ES+) RT 1.51 minutes, 275/277 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,905563-79-3, its application will become more common.

Reference:
Patent; UCB BIOPHARMA SPRL; SANOFI; DELIGNY, Michael Louis Robert; HEER, Jag Paul; (86 pag.)WO2017/167993; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 905563-79-3, name is 2-Chloro-4-methoxynicotinaldehyde. A new synthetic method of this compound is introduced below., Quality Control of 2-Chloro-4-methoxynicotinaldehyde

(2) Synthesis of 2-chloro-4-methoxy-3-(2-methoxyvinyl)pyridine Under nitrogen atmosphere, 4.07g of (methoxymethyl) triphenylphosphonium chloride was suspended in 50ml of tetrahydrofuran, 1.37g of potassium tert-butoxide was added in an ice-cooling, which was stirred for 10 minutes. 1.02g of 2-chloro-4-methoxypyridine-3-carbaldehyde was dissolved in 20ml of tetrahydrofuran, which was added to reaction liquid, and was stirred for another 40 minutes. Water and diethyl ether were added to reaction liquid, and the organic layer was separated. The resulting organic layer was washed with brine and then dried over anhydrous sodium sulfate. The reaction liquid was concentrated under a reduced pressure after removal of drying agent by filtration. The residue was purified by NH silica gel column chromatography (hexane-ethyl acetate) to give 1.18g of the title compound as a mixture of the geometric isomers.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 905563-79-3, 2-Chloro-4-methoxynicotinaldehyde.

Reference:
Patent; Eisai R&D Management Co., Ltd.; EP1847535; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 905563-79-3, name is 2-Chloro-4-methoxynicotinaldehyde. A new synthetic method of this compound is introduced below., Quality Control of 2-Chloro-4-methoxynicotinaldehyde

(2) Synthesis of 2-chloro-4-methoxy-3-(2-methoxyvinyl)pyridine Under nitrogen atmosphere, 4.07g of (methoxymethyl) triphenylphosphonium chloride was suspended in 50ml of tetrahydrofuran, 1.37g of potassium tert-butoxide was added in an ice-cooling, which was stirred for 10 minutes. 1.02g of 2-chloro-4-methoxypyridine-3-carbaldehyde was dissolved in 20ml of tetrahydrofuran, which was added to reaction liquid, and was stirred for another 40 minutes. Water and diethyl ether were added to reaction liquid, and the organic layer was separated. The resulting organic layer was washed with brine and then dried over anhydrous sodium sulfate. The reaction liquid was concentrated under a reduced pressure after removal of drying agent by filtration. The residue was purified by NH silica gel column chromatography (hexane-ethyl acetate) to give 1.18g of the title compound as a mixture of the geometric isomers.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 905563-79-3, 2-Chloro-4-methoxynicotinaldehyde.

Reference:
Patent; Eisai R&D Management Co., Ltd.; EP1847535; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 905563-79-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 905563-79-3, name is 2-Chloro-4-methoxynicotinaldehyde, molecular formula is C7H6ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 2: 2-Chloro-4-methoxypyridin-3-yl)methanol (26) A solution of 2-chloro-4-methoxynicotinaldehyde (0.190 g, 1.11 mmol) in methanol (10 mL) was treated with sodium borohydride (0.044 g, 1.2 mmol) and stirred at RT for 1 hour. The reaction was concentrated in vacuo, redissolved in ethyl acetate, washed with water and brine, dried over sodium sulfate, filtered and concentrated, providing the crude title compound which was used without further purification. LRMS m/z (M+H) 174.2 found, 174.1 required.

According to the analysis of related databases, 905563-79-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; SKUDLAREK, Jason, W.; WO2014/176144; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem