Category: 909036-46-0

Synthetic Route of 909036-46-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 909036-46-0, name is 2-Chloro-3-iodopyridin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.

Into a 250 mL round bottom flask was placed the 2-chloro-3-iodo-4-aminopyridine (3.0 g, 11.8 mmol), thiophenol (1.3 g, 11.8 mmol), copper(I) iodide (0.11 g, 0.58 mmol), ethylene glycol (1.5 g, 24 mmol) and potassium carbonate (3.3 g, 24 mol). 100 mL of 2-propanol was then added to the reaction mixture and the mixture was heated at reflux for 18 h. The reaction mixture was cooled to room temperature and was filtered under vacuum. The filtrate was diluted with 200 mL of water then was extracted two times with 150 mL of ethyl acetate. The extracts were dried over magnesium sulfate then were filtered and stripped under vacuum. The product was purified using Silica gel chromatography with 2-15% ethyl acetate/dichloromethane as the mobile phase. 2.0 g (72% yield of product was collected.

According to the analysis of related databases, 909036-46-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Universal Display Corporation; Rayabarapu, Dinesh; Xia, Chuanjun; Kwong, Raymond; Ma, Bin; Yeager, Walter; Alleyne, Bert; (82 pag.)CN102449107; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 909036-46-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 909036-46-0, name is 2-Chloro-3-iodopyridin-4-amine. A new synthetic method of this compound is introduced below.

10.4 Synthesis of N-(2-chloro-3-iodo-pyridin-4-yl)methanesulfonamide 3a* 2-Chloro-3-iodo-pyridin-4-ylamine 2a* (5.1 g, 20 mmol) and triethylamine (14 mL, 100 mmol) were stirred in DCM (100 mL) and cooled in an ice water bath. Methanesulphonyl chloride (7.7 mL, 100 mmol) was added dropwise and stirred at room temperature for two h. The reaction mixture was washed with water (100 mL), dried over MgSO4 and concentrated in vacuo. The crude product was purified by column chromatography using 1% AcOEt in DCM to yield N-methanesulfonamide-N-(2-chloro-3-iodo-pyridin-4-yl)-methanesulfonamide (4.2 g, 51 %). 1H NMR (400 MHz, DMSO) delta(ppm): 8.53 (1 H, d, J = 5.1 Hz), 7.74 (1 H, d, J = 5.1 Hz), 3.70 (6 H, s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,909036-46-0, 2-Chloro-3-iodopyridin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.; Ullrich, Axel (Prof. Dr.); Falcenberg, Mathias (Dr.); EP2818472; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem