Category: 91-02-1

Supramolecular assemblies of new pseudohalide end-to-end bridged copper(II) complex and molecular structural variety of penta and hexa-coordinated metal(II) complexes with hydrazido-based ligand was written by Singh, Yogendra;Patel, R. N.;Patel, S. K.;Jadeja, R. N.;Patel, A. K.;Patel, N.;Roy, H.;Bhagriya, P.;Singh, Rita;Butcher, R. J.;Jasinski, Jerry P.;Herrero, S.;Cortijo, M.. And the article was included in Inorganica Chimica Acta in 2020.SDS of cas: 91-02-1 This article mentions the following:

With an hydrazido-based ligand, C₁₄H₁₃N₂O and Cu, Ni metal(II) salts, three new mononuclear [Ni(HL)(NO₃)(H₂O)]NO₃,C₁₄H₁₅N₅NiO₈ (1), [Cu(HL)(H₂O)₂].2NO₃, C₁₄H₁₇CuN₅O₄ (2), [Ni(HL)₂].2ClO₄, C₂₈H₃₀Cl₂N₆NiO₁₂ (3) and one binuclear end-to-end thiocynate bridged [Cu₂(μ-SCN)₂(L)₂], C₃₀H₂₄Cu₂N₈O₂S₂ (4) complexes have been synthesized and characterized by physico-chem. techniques. All of the complexes were structurally characterized using single crystal X-ray diffraction. Complexes 1 and 2 have a penta-coordinated environment around the metal(II) center, whereas complex 3 has a distorted hexa-coordinated geometry. In complex 4 two symmetry related, adjacent copper(II) coordination moieties are joined end-to-end in an unprecedented manner forming a thiocynate bridged, yielding a dicopper entity. The presence of two “sym.” thiocynate bridges with Cu-SCN and Cu-NCS distances of 2.832 Å and 1.925 Å, resp., results in a Cu···Cu distance of 5.503 Å. Binuclear complex, 4 exhibits a weak antiferromagnetic interaction between adjacent copper(II) centers. These copper(II) mononuclear and binuclear complexes have also been studied by X-band EPR. The crystal packing of these new complexes is stabilized by H-bonding, weak intermol. interactions, CH···π and π···π interactions. Electrochem. data (CV and DPV) for the complexes shows M^II → M^I reduction activity. Electronic spectroscopy and computational features are examined by quantum chem. studies. The inhibitory effect of the complexes were tested on a cell population with IMR 32 (neuroblastoma), MCF 7 (breast cancer), HepG2 (hepatocellular carcinoma), L132 (lung cells) cell lines by MTT assay. Complex 3 showed a prominent cytotoxicity against the all cell lines. Expression levels of the Bax (pro-apoptotic) and Bcl2 (anti-apoptotic) genes were also studied, wherein the genes of interest showed a moderate down regulation after treatment with complexes 1 and 3. Finally, antioxidant superoxide dismutase activity measurements show that the complexes behave as superoxide dismutase mimics. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1SDS of cas: 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.SDS of cas: 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Metal-free oxidative C(sp³)-H functionalization: a facile route to quinoline formaldehydes from methyl-azaheteroarenes was written by Weng, Wei-Zhao;Guo, Jiang-Shan;Liu, Kai-Xuan;Shao, Tian-Qi;Song, Li-Qun;Zhu, Yan-Ping;Sun, Yuan-Yuan;Meng, Qing-Guo. And the article was included in Canadian Journal of Chemistry in 2020.HPLC of Formula: 91-02-1 This article mentions the following:

A facile protocol for the synthesis of quinoline formaldehydes, e.g., I via direct oxidative C-H bond functionalization of methyl-azaheteroarenes in the presence of I₂-DMSO has been described. This method is metal-free and easy to operate. This reaction provided a convenient route for the preparation of a range of important quinoline formaldehydes. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1HPLC of Formula: 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. HPLC of Formula: 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis, Study, and Application of Pd(II) Hydrazone Complexes as the Emissive Components of Single-Layer Light-Emitting Electrochemical Cells was written by Emami, Marzieh;Shahroosvand, Hashem;Bikas, Rahman;Lis, Tadeusz;Daneluik, Cody;Pilkington, Melanie. And the article was included in Inorganic Chemistry in 2021.Application In Synthesis of Phenyl(pyridin-2-yl)methanone This article mentions the following:

For the first time, square planar Pd(II) complexes of hydrazone ligands have been investigated as the emissive components of light-emitting electrochem. cells (LECs). The neutral transition metal complex, [Pd(L¹)₂]·2CH₃OH (1), (HL¹ = (E)-N′-(phenyl(pyridin-2-yl)methylene)isonicotinhydrazide), was prepared and structurally characterized. Complex 1 displays quasireversible redox properties and is emissive at room temperature in solution with a λ_max of 590 nm. As a result, it was subsequently employed as the emissive material of a single-layer LEC with configuration FTO/1/Ga/In, where studies reveal that it has a yellow color with CIE(x, y) = (0.33, 0.55), a luminance of 134 cd cm^-2, and a turn-on voltage of 3.5 V. Protonation of the pendant pyridine nitrogen atoms of L¹ afforded a second ionic complex [Pd(L¹H)₂](ClO₄)₂ (2) which is also emissive at room temperature with a λ_max of 611 nm, resulting in an orange LEC with CIE(x, y) = (0.43, 0.53). The presence of mobile anions and cations in the second inorganic transition metal complex resulted in more efficient charge injection and transport which significantly improved the luminance and turn-on voltage of the device to 188.6 cd cm^-2 and 3 V, resp. This study establishes Pd(II) hydrazone complexes as a new class of materials whose emissive properties can be chem. tuned and provides proof-of-concept for their use in LECs, opening up exciting new avenues for potential applications in the field of solid state lighting. The emissive properties of two Pd(II) hydrazone complexes have been exploited for the fabrication of single-layer light-emitting electrochem. cells. We demonstrate that a neutral Pd(II) complex capable of undergoing proton transfer with the solvent can support a suitable ionic medium for LECs. Furthermore, selective protonation of the hydrazone ligands and the introduction of perchlorate counterions afford a second LEC device with increased c.d., a red-shifted emission, and significantly improved brightness. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Application In Synthesis of Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application In Synthesis of Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

[CN̂]-Alkenyl Gold(III) Complexes by Proximal Ring-Opening of (2-Pyridyl)alkylidenecyclopropanes: Mechanistic Insights was written by Gonzalez, Jorge A.;Verdugo, Felipe;Mascarenas, Jose Luis;Lopez, Fernando;Nevado, Cristina. And the article was included in Angewandte Chemie, International Edition in 2020.Electric Literature of C12H9NO This article mentions the following:

Pyridine-substituted alkylidenecyclopropanes (Py-ACPs) react with gold(III) salts under mild reaction conditions through an unprecedented, proximal ring-opening pathway, to generate highly appealing, catalytically active pyridine alkenyl [CN̂]-gold(III) species. Mechanistic studies reveal that the activation of the C-C bond of the ACP takes place through an unusual concerted, σ-bond metathesis type-process. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Electric Literature of C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Electric Literature of C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Selective α-Deuteration of Cinnamonitriles using D₂O as Deuterium Source was written by Guo, Beibei;de Vries, Johannes G.;Otten, Edwin. And the article was included in Advanced Synthesis & Catalysis in 2022.Formula: C12H9NO This article mentions the following:

The selective α-deuteration of α,β-unsaturated nitriles using the strong base t-BuOK or a metal-ligand cooperative Ru pincer catalyst was described. With D₂O as deuterium source and glyme as solvent at 70°C, t-BuOK is an efficient catalyst for deuteration at the α-C(sp²) position of cinnamonitriles, providing access to a broad range of deuterated derivatives in good to excellent yields and with very high levels of deuterium incorporation. While the t-BuOK-catalyzed protocol does not tolerate base-sensitive functional groups, cinnamonitrile derivatives containing a benzylic bromide or ester moiety were deuterated in excellent yields using Milstein’s ruthenium PNN pincer catalyst. Moreover, the activity for H/D exchange of the metal-ligand cooperative Ru catalyst was found to be significantly higher than that of t-BuOK, allowing reactions to proceed well even at room temperature A mechanistic proposal is put forward that involves deprotonation of the cinnamonitrile α-CH position when using t-BuOK as catalyst, whereas H/D exchange catalysis with the Ru PNN pincer likely proceeds via (reversible) oxa-Michael addition of D₂O. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Formula: C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Assessment of cytotoxic and genotoxic potentials of a mononuclear Fe(II) Schiff base complex with photocatalytic activity in Trigonella was written by Mahapatra, Kalyan;Ghosh, Ayon Kanti;De, Sayanti;Ghosh, Noyel;Sadhukhan, Pritam;Chatterjee, Sharmistha;Ghosh, Rajarshi;Sil, Parames C.;Roy, Sujit. And the article was included in Biochimica et Biophysica Acta, General Subjects in 2020.Related Products of 91-02-1 This article mentions the following:

In recent times, coordination complexes of iron in various oxidation states along with variety of ligand systems have been designed and developed for effective treatment of cancer cells without adversely affecting the normal cell and tissues of various organs. In this study, we have evaluated the mechanism of action of a Fe(II) Schiff base complex in the crop plant Trigonella foenum-graecum L. (Fenugreek) as the screening system by using morphol., cytol., biochem. and mol. approaches. Further functional characterization was performed using MCF-7 cell line and solid tumor model for the assessment of anti-tumor activity of the complex. Our results indicate efficiency of the Fe(II) Schiff base complex in the induction of double strand breaks in DNA. Complex treatment clearly induced cytotoxic and genotoxic damage in Trigonella seedlings. The Fe-complex treatment caused cell cycle arrest via the activation of ATM-ATR kinase mediated DNA damage response pathway with the compromised expression of CDK1, CDK2 and CyclinB1 protein in Trigonella seedlings. In cultured MCF-7 cells, the complex induces cytotoxicity and DNA fragmentation through intracellular ROS generation. Fe-complex treatment inhibited tumor growth in solid tumor model with no addnl. side effects. The growth inhibitory and cytotoxic effects of the complex result from activation of DNA damage response along with oxidative stress and cell cycle arrest. Overall, our results have provided comprehensive information on the mechanism of action and efficacy of a Fe(II) Schiff base complex in higher eukaryotic genomes and indicated its future implications as potential therapeutic agent. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Related Products of 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Related Products of 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fluorenone Schiff base derivative complexes of ruthenium, rhodium and iridium exhibiting efficient antibacterial activity and DNA-binding affinity was written by Kollipara, Mohan Rao;Shadap, Lathewdeipor;Banothu, Venkanna;Agarwal, Nipanshu;Poluri, Krishna Mohan;Kaminsky, Werner. And the article was included in Journal of Organometallic Chemistry in 2020.Computed Properties of C12H9NO This article mentions the following:

Half-sandwich ruthenium, rhodium and iridium pyridyl fluorenylidene azine Schiff base complexes [LMCl(2-pyCR:NN:Fl)] (1–9; M = Ru, L = p-cymene; M = Rh, Ir, L = C₅Me₅; R = Ph, Me, H; py = pyridyl, Fl = 9-fluorenylidene) were prepared and examined for their antibacterial activity. Metal precursors [(arene)MCl₂]₂ (arene = p-cymene, Cp*; M = Ru, Rh and Ir) on reacting with 9-fluorenone derivative ligands L1, L2 and L3 resulted in the formation of mononuclear bidentate cationic N-N bonded complexes. The biol. studies of these complexes such as antibacterial activity studies (against Gram-pos. and Gram-neg. bacteria) revealed significant antibacterial activity with complexes 4, 7 and 9 having the highest activity potency (in-vitro). While for DNA-binding studies, the results revealed that complexes 4 and 5 displayed significant changes in their spectral features upon addition of SM-DNA, thus, indicating that these complexes bind to DNA with a significant affinity. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Computed Properties of C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Computed Properties of C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Asymmetric Transfer Hydrogenative Amination of Benzylic Ketones Catalyzed by Cp*Ir(III) Complexes Bearing a Chiral N-(2-Picolyl)sulfonamidato Ligand was written by Kawada, Takuma;Yabushita, Kenya;Yasuda, Toshihisa;Ohta, Takeshi;Yajima, Takaaki;Tanaka, Kouichi;Utsumi, Noriyuki;Watanabe, Masahito;Murata, Kunihiko;Kayaki, Yoshihito;Kuwata, Shigeki;Katayama, Takeaki. And the article was included in Journal of Organic Chemistry in 2022.Name: Phenyl(pyridin-2-yl)methanone This article mentions the following:

A convenient asym. reductive amination of benzylic ketones (α-arylated ketones) catalyzed by newly designed Cp*Ir complexes bearing a chiral N-(2-picolyl)sulfonamidato ligand was developed. Using readily available β-amino alcs. as chiral aminating agents, a range of benzo-fused and acyclic ketones were successfully reduced with formic acid in methanol at 40°C to afford amines with favorable chemo- and diastereoselectivities. The amino alc.-derived chiral auxiliary was easily removed by mild periodic oxidants, leading to optically active primary β-arylamines without erosion of the optical purity (up to 97% ee). The excellent catalytic performance was retained even upon lowering the amount of catalyst to a substrate/catalyst (S/C) ratio of 20,000, and the amination could be performed on a large scale exceeding 100 g. The precise hydride transfer to iminium species generated from the ketonic substrate and the chiral amine counterpart was suggested by the mechanistic studies on stoichiometric reactions of isolable hydridoiridium complexes and model intermediates such as N,O-acetal, enamine, and iminium compounds In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Name: Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Name: Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Scandium(III) Triflate Catalyzed Direct Synthesis of N-Unprotected Ketimines was written by Kondo, Yuta;Kadota, Tetsuya;Hirazawa, Yoshinobu;Morisaki, Kazuhiro;Morimoto, Hiroyuki;Ohshima, Takashi. And the article was included in Organic Letters in 2020.Product Details of 91-02-1 This article mentions the following:

N-Unprotected ketimines are useful substrates and intermediates for synthesizing valuable nitrogen-containing compounds, but their potential applicability is limited by the available synthetic methods. To address this issue, we report a scandium(III) triflate catalyzed direct synthesis of N-unprotected ketimines. Using com. available reagents and Lewis acid catalysts, ketones were directly transformed into the corresponding N-unprotected ketimines in high yields with broad functional group tolerance, even in multigram scales. The reactions were readily applicable for one-pot synthesis of important compounds such as a glycine Schiff base without isolation of N-unprotected ketimine intermediates. Preliminary mechanistic studies to clarify the reaction mechanism are also described. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Product Details of 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Product Details of 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of thiosemicarbazone derivatives as effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates was written by Zhao, Bing;Zhang, Xinhui;Yu, Tingting;Liu, Ying;Zhang, Xiaoling;Yao, Yongfang;Feng, Xuejian;Liu, Hongmin;Yu, Dequan;Ma, Liying;Qin, Shangshang. And the article was included in Acta Pharmaceutica Sinica B in 2021.Recommanded Product: Phenyl(pyridin-2-yl)methanone This article mentions the following:

In this study, structure-activity relationship based on thiosemicarbazone derivatives (E)-R¹C(S)NHN=C(R²)(R³) (I) (R¹ = phenylamino, Ph, cyclohexylamino, morpholin-4-yl, etc.; R² = H, Me; R³ = Ph, pyridin-2-yl, 3,4,5-trimethoxyphenyl, etc.) was systematically characterized and their potential activities combined with meropenem (MEM) were evaluated. Compounds (I).HCl [R¹ = piperazin-1-yl, R² = H, R³ = 2-hydroxyphenyl (II); R¹ = 4-methylpiperazin-1-yl, R² = H, R³ = 2-hydroxyphenyl (III)] exhibited excellent activity against 10 NDM-pos. isolate clin. isolates in reversing MEM resistance. Further studies demonstrated that compounds II and III were uncompetitive NDM-1 inhibitors with Ki = 0.63 and 0.44μmol/L, resp. Mol. docking speculated that compounds II and III were most likely to bind in the allosteric pocket which would affect the catalytic effect of NDM-1 on the substrate meropenem. Toxicity evaluation experiment showed that no hemolysis activities were found even at concentrations of 1000 mg/mL against red blood cells. In vivo exptl. results showed that a combination of MEM and compound III was markedly effective in treating infections caused by NDM-1 pos. strain and prolonging the survival time of sepsis mice. The finding showed that compound III might be a promising lead in developing new inhibitor to treat NDM-1 producing superbug. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Recommanded Product: Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Recommanded Product: Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem