Category: 91-02-1

HPLC of Formula: C12H9NO. In 2019.0 DYES PIGMENTS published article about MULTINUCLEAR MAGNETIC-RESONANCE; X-RAY-DIFFRACTION; SOLID-STATE NMR; INTERMOLECULAR INTERACTIONS; OXIDATIVE AMINATION; FACILE SYNTHESIS; BLUE-LIGHT; COMPLEXES; EFFICIENT; IMIDAZO in [Volpi, Giorgio; Garino, Claudio; Priola, Emanuele; Magistris, Claudio; Chierotti, Michele R.; Barolo, Claudia] Univ Torino, Dipartimento Chim, NIS Interdept Ctr, Via Pietro Giuria 7, I-10125 Turin, Italy in 2019.0, Cited 62.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

A series of halogenated imidazo[1,5-alpha]pyridines was prepared and their structural and optical properties investigated. The products were characterized by spectroscopic techniques and their optical properties discussed in relation to their chemical structure. We were able to triplicate the luminescence quantum yields (phi) in solution for three different imidazo[1,5-alpha]pyridine derivatives, depending on the halogen nature of the substituent on the imidazo[1,5-alpha]pyridine moiety. The effect of the halogen and of the geometrical and chemical characteristics of the molecular skeleton on the crystal packing was studied in the solid state by single crystal X-ray diffraction. At the same time, the possible presence of halogen bonds was evaluated through solid-state NMR analysis.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Engineering an alcohol dehydrogenase with enhanced activity and stereoselectivity toward diaryl ketones: reduction of steric hindrance and change of the stereocontrol element WOS:000526708900006 published article about CARBONYL REDUCTASE; INSIGHTS; PROLINE; MUTAGENESIS; CATALYSIS; DYNAMICS; PRELOG; POCKET; OXIDE; SHAPE in [Wu, Kai; Yang, Zhijun; Meng, Xiangguo; Chen, Rong; Huang, Jiankun] Shanghai Univ Med & Hlth Sci, Sch Pharm, 279 Zhouzhu Highway,Pudong New Area, Shanghai 201318, Peoples R China; [Wu, Kai; Yang, Zhijun; Meng, Xiangguo; Shao, Lei] Shanghai Univ Med & Hlth Sci, Microbial Pharmacol Lab, 279 Zhouzhu Highway,Pudong New Area, Shanghai 201318, Peoples R China; [Shao, Lei] Shanghai Inst Pharmaceut Ind, State Key Lab New Drug & Pharmaceut Proc, 285 Gebaini Rd, Shanghai 200040, Peoples R China in 2020.0, Cited 44.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Recommanded Product: Phenyl(pyridin-2-yl)methanone

Steric hindrance in the binding pocket of an alcohol dehydrogenase (ADH) has a great impact on its activity and stereoselectivity simultaneously. Due to the subtle structural difference between two bulky phenyl substituents, the asymmetric synthesis of diaryl alcohols by bioreduction of diaryl ketones is often hindered by the low activity and stereoselectivity of ADHs. To engineer an ADH with practical properties and to investigate the molecular mechanism behind the asymmetric biocatalysis of diaryl ketones, we engineered an ADH from Lactobacillus kefiri (LkADH) to asymmetrically catalyse the reduction of 4-chlorodiphenylketones (CPPK), which are not catalysed by the wild type (WT) enzyme. Mutants seq1-seq5 with gradually increased activity and stereoselectivity were obtained through iterative shrinking mutagenesis. The final mutant seq5 (Y190P/I144V/L199V/E145C/M206F) demonstrated the highest activity and excellent stereoselectivity of >99% ee. Molecular simulation analyses revealed that mutations may enhance the activity by eliminating steric hindrance, inducing a more open binding loop and constructing more noncovalent interactions. The pro-R pose of CPPK with a halogen bond formed a pre-reaction conformation more easily than the pro-S pose, resulting in the high ee of (R)-CPPO in seq5. Moreover, different halogen bonds formed due to the different positions of chlorine substituents, resulting in opposite substrate binding orientation and stereoselectivity. Therefore, the stereoselectivity of seq5 was inverted toward ortho- rather than para-chlorine substituted ketones. These results indicate that the stereocontrol element of LkADH was changed to recognise diaryl ketones after steric hindrance was eliminated. This study provides novel insights into the role of steric hindrance and noncovalent bonds in the determination of the activity and stereoselectivity of enzymes, and presents an approach producing key intermediates of chiral drugs with practical potential.

Recommanded Product: Phenyl(pyridin-2-yl)methanone. Welcome to talk about 91-02-1, If you have any questions, you can contact Wu, K; Yang, ZJ; Meng, XG; Chen, R; Huang, JK; Shao, L or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Development of a Tunable Chiral Pyridine Ligand Unit for Enantioselective Iridium-Catalyzed C-H Borylation WOS:000664333800056 published article about C(SP(3))-H BORYLATION; BIPYRIDINE LIGAND; ARENES; ACTIVATION; COMPLEXES; CYCLOPROPANATION; C(SP(2))-H; FUNCTIONALIZATION; BONDS in [Song, Peidong; Yu, Tao; Li, Pengfei] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710054, Peoples R China; [Hu, Linlin; He, Yangqing] Xian Univ Technol, Dept Appl Chem, Xian 710048, Peoples R China; [Jiao, Jiao] Xi An Jiao Tong Univ, Sch Chem, Xian Key Lab Sustainable Energy Mat Chem, Xian 710049, Peoples R China; [Xu, Liang] Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832003, Peoples R China; [Li, Pengfei] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China in 2021.0, Cited 104.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Computed Properties of C12H9NO

Although pyridine derivatives are versatile supporting ligands in catalysis, the development of their chiral versions has been relatively limited. Herein, we report the design, synthesis, and proof-of-concept application of a structurally tunable chiral pyridine framework featuring an annulated compact ring system. Using an N,B-bidentate ligand skeleton containing the chiral pyridine moiety, we have developed an enantioselective iridium-catalyzed desymmetrizing C-H borylation reaction of diaryl(2-pyridyl)methane compounds with up to 96% ee and 93% yield. The resulting borylation products could be readily transformed into various chiral tri(hetero)arylmethane compounds. Density functional theory investigations revealed that the two chair conformations of the flexible ketal motif both favored the enantiomer that was consistent with experimental results. This work has thus introduced an effective and tunable chiral pyridine ligand framework that may be used in many catalytic asymmetric transformations.

Computed Properties of C12H9NO. Welcome to talk about 91-02-1, If you have any questions, you can contact Song, PD; Hu, LL; Yu, T; Jiao, J; He, YQ; Xu, L; Li, PF or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Ardila-Fierro, KJ; Bolm, C; Hernandez, JG in WILEY-V C H VERLAG GMBH published article about FUNCTIONALIZED GRAPHENE NANOPLATELETS; CALCIUM CARBIDE; SOLVENT-FREE; MECHANOCHEMISTRY; FORCE in [Ardila-Fierro, Karen J.; Bolm, Carsten; Hernandez, Jose G.] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany in 2019.0, Cited 64.0. Formula: C12H9NO. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

A mechanochemical synthesis of one-dimensional carbon allotrope carbyne model compounds, namely tetraaryl[n]cumulenes (n=3, 5) was realized. Central for the mechanosynthesis of the cumulenic carbon nanostructures were the development of a mechanochemical Favorskii alkynylation-type reaction and the implementation of a solvent-free, acid-free reductive elimination with tin(II) chloride by ball milling.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 APPL ORGANOMET CHEM published article about AEROBIC ALCOHOL OXIDATION; PALLADIUM NANOPARTICLES; COUPLING REACTIONS; HIGHLY EFFICIENT; SELECTIVITY; SURFACE; SUZUKI in [Ampawa, Supanan; Krittametaporn, Nuttaporn; Sangtrirutnugul, Preeyanuch] Mahidol Univ, Ctr Excellence Innovat Chem PERCH CIC, Ctr Catalysis, Dept Chem,Fac Sci, 272 Rama VI Rd, Bangkok 10400, Thailand; [Ungpittagul, Thasanaporn; Phomphrai, Khamphee] Vidyasirimedhi Inst Sci & Technol, Sch Mol Sci & Engn, Dept Mat Sci & Engn, Rayong 21210, Thailand in 2019.0, Cited 32.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Category: pyridine-derivatives

Triazole-based ligands, tris (triazolyl)methanol (Htbtm), bis (triazolyl)-phenylmethanol (Hbtm), and phenyl (pyridin-2-yl)(triazolyl)methanol (Hpytm), with differences in ligand denticity (i.e., bidentate and tridentate) and type of N donors (i.e., triazole and pyridine) were functionalized onto a silica support to produce the corresponding SiO2-L (L = tbtm, btm, pytm). Subsequent reactions with Pd (CH3COO)(2) in CH2Cl2 yielded Pd/SiO2-L. ICP-MS reveals that Pd loadings are higher with increased N loadings, resulting in the following trend: Pd/SiO2-tbtm (0.83 mmol Pd g(-1)) > Pd/SiO2-btm (0.65 mmol Pd g(-1)) ~ Pd/SiO2-pytm (0.63 mmol Pd g(-1)). Meanwhile, TEM images of the used Pd/SiO2-L catalysts after the first catalytic cycle show that the mean size of Pd NPs is highest with Pd/SiO2-pytm (8.5 +/- 1.5 nm), followed by Pd/SiO2-tbtm (6.4 +/- 1.6 nm) and Pd/SiO2-btm (4.8 +/- 1.3 nm). Based on TONs, catalytic studies toward aerobic oxidation of benzyl alcohol to benzaldehyde at 60 degrees C in EtOH showed that Pd/SiO2-pytm possessed the most active surface Pd(0) atoms, most likely as a result of more labile properties of the pyridine-triazole ligand compared to tris- and bis (triazolyl) analogs. ICP-MS and TEM analysis of Pd/SiO2-btm indicate minimal Pd leaching and similar average Pd NPs sizes after 1(st) and 5(th) catalytic runs, respectively, confirming that SiO2-btm is an efficient Pd NPs stabilizer. The Pd/SiO2-btm catalyst was also active toward aerobic oxidation of various benzyl alcohol derivatives in EtOH and could be reused for at least 7 reaction cycles without a significant activity loss.

Category: pyridine-derivatives. Welcome to talk about 91-02-1, If you have any questions, you can contact Ampawa, S; Krittametaporn, N; Ungpittagul, T; Phomphrai, K; Sangtrirutnugul, P or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

COA of Formula: C12H9NO. You, SY; Yan, CY; Zhang, RL; Cai, MZ in [You, Shengyong; Zhang, Rongli; Cai, Mingzhong] Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China; [You, Shengyong; Zhang, Rongli; Cai, Mingzhong] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China; [Yan, Chenyu] Jiangxi Normal Univ, Affiliated Middle Sch, Nanchang 330022, Jiangxi, Peoples R China; [You, Shengyong] Jiangxi Acad Sci, Inst Appl Chem, Nanchang 330029, Jiangxi, Peoples R China published A convenient and practical heterogeneous palladium-catalyzed carbonylative Suzuki coupling of aryl iodides with formic acid as carbon monoxide source in 2019.0, Cited 82.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

A practical heterogeneous palladium-catalyzed carbonylative Suzuki coupling of aryl iodides with arylboronic acids under carbon monoxide gas-free conditions has been developed using a bidentate phosphino-functionalized magnetic nanoparticle-immobilized palladium(II) complex as catalyst. Formic acid was utilized as the carbon monoxide source with dicyclohexylcarbodiimide as the activator, and a wide variety of biaryl ketones were generated in moderate to high yields. The new heterogeneous palladium catalyst can be prepared via a simple procedure and can easily be separated from a reaction mixture by simply applying an external magnet and recycled up to 10 times without any loss of activity.

COA of Formula: C12H9NO. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Dong, C; Wang, X; Pei, ZB; Sheno, RW in [Dong, Chao; Wang, Xin; Pei, Zibo; Sheno, Ruwei] Nanjing Tech Univ, Coll Chem Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 211800, Jiangsu, Peoples R China published Metal-Free Denitrogenative C-C Couplings of Pyridotriazoles with Boronic Acids To Afford alpha-Secondary and alpha-Tertiary Pyridines in 2019.0, Cited 84.0. Name: Phenyl(pyridin-2-yl)methanone. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

Pyridotriazoles are utilized as robust building blocks to access alpha-secondary and alpha-tertiary pyridines via the development of a simple yet practically useful metal-free denitrogenative C-C cross-coupling with boronic acids. The reaction shows a high level of functional tolerance, broad substrate scope, and facile scalability. The synthetic potential of the method is demonstrated by the strurctural modification of a bioactive molecule and concise synthesis of pheniramine analogs.

Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.. Name: Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Conformational Dynamics-Guided Loop Engineering of an Alcohol Dehydrogenase: Capture, Turnover and Enantioselective Transformation of Difficult-to-Reduce Ketones WOS:000484142600018 published article about THERMOANAEROBACTER-ETHANOLICUS; SATURATION MUTAGENESIS; MOLECULAR-DYNAMICS; DIRECTED EVOLUTION; SUBSTRATE-SPECIFICITY; ASYMMETRIC REDUCTION; BIOCATALYSIS; KETOREDUCTASE; MUTATION; ENZYME in [Liu, Beibei; Xu, Yan; Nie, Yao] Jiangnan Univ, Sch Biotechnol, Key Lab Ind Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China; [Liu, Beibei; Qu, Ge; Li, Jun-Kuan; Fan, Wenchao; Sun, Zhoutong] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin Airport Econ Area, 32 West 7th Ave, Tianjin 300308, Peoples R China; [Li, Jun-Kuan; Ma, Jun-An] Tianjin Univ, Tianjin Key Lab Mol Optoelect Sci, Dept Chem, Tianjin 300072, Peoples R China; [Li, Jun-Kuan; Ma, Jun-An] Tianjin Univ, Tianjin Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China in 2019, Cited 82. Category: pyridine-derivatives. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

Directed evolution of enzymes for the asymmetric reduction of prochiral ketones to produce enantio-pure secondary alcohols is particularly attractive in organic synthesis. Loops located at the active pocket of enzymes often participate in conformational changes required to fine-tune residues for substrate binding and catalysis. It is therefore of great interest to control the substrate specificity and stereochemistry of enzymatic reactions by manipulating the conformational dynamics. Herein, a secondary alcohol dehydrogenase was chosen to enantioselectively catalyze the transformation of difficult-to-reduce bulky ketones, which are not accepted by the wildtype enzyme. Guided by previous work and particularly by structural analysis and molecular dynamics (MD) simulations, two key residues alanine 85 (A85) and isoleucine 86 (I86) situated at the binding pocket were thought to increase the fluctuation of a loop region, thereby yielding a larger volume of the binding pocket to accommodate bulky substrates. Subsequently, site-directed saturation mutagenesis was performed at the two sites. The best mutant, where residue alanine 85 was mutated to glycine and isoleucine 86 to leucine (A85G/I86L), can efficiently reduce bulky ketones to the corresponding pharmaceutically interesting alcohols with high enantioselectivities (similar to 99% ee). Taken together, this study demonstrates that introducing appropriate mutations at key residues can induce a higher flexibility of the active site loop, resulting in the improvement of substrate specificity and enantioselectivity.

Welcome to talk about 91-02-1, If you have any questions, you can contact Liu, BB; Qu, G; Li, JK; Fan, WC; Ma, JA; Xu, Y; Nie, Y; Sun, ZT or send Email.. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Photoredox-Catalyzed Enantioselective alpha-Deuteration of Azaarenes with D2O WOS:000473321700033 published article about 1,2-ASYMMETRIC INDUCTION; ALLYLATION REACTIONS; RADICAL REACTIONS; REDUCTION; CHEMISTRY; DISCOVERY; EXCHANGE; KETONES in [Shao, Tianju; Li, Yajuan; Li, Chunyang; Zhao, Xiaowei; Qiao, Baokun; Jiang, Zhiyong] Henan Univ, Key Lab Nat Med & Immunoengn Henan Prov, Kaifeng 475004, Henan, Peoples R China; [Ma, Nana; Jiang, Zhiyong] Henan Normal Univ, Henan Key Lab Organ Funct Mol & Drug Innovat, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China; [Chai, Guobi] Zhengzhou Tobacco Res CNTC, Zhengzhou 450001, Henan, Peoples R China in 2019.0, Cited 61.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Application In Synthesis of Phenyl(pyridin-2-yl)methanone

The site-specific incorporation of deuterium (D) into small molecules is frequently used to access isotopically labeled compounds with broad utility in many research areas, such as drug development, mechanistic studies, and NMR analyses. Nevertheless, the deuteration of a stereocenter in an enantioselective manner, which could slow the metabolism and improve the bioavailability of bioactive molecules, remains challenging owing to the lack of established catalytic methods. Here, we report an asymmetric alpha-deuteration strategy for azaarenes with inexpensive D2O as the deuterium source. A cooperative visible light-driven photoredox and chiral Bronsted acid-catalyzed system using a Hantzsch ester as the terminal reductant has been developed, which enables racemic alpha-chloro-azaarenes and prochiral azaarene-substituted ketones to experience a single-electron reduction-enantioselective deuteration process. The transition metal-free method provides important chiral alpha-deuterated azaarenes in satisfactory yields with good to excellent enantioselectivities (up to 99% ee) and substantial deuterium incorporation.

Application In Synthesis of Phenyl(pyridin-2-yl)methanone. Welcome to talk about 91-02-1, If you have any questions, you can contact Shao, TJ; Li, YJ; Ma, NN; Li, CY; Chai, GB; Zhao, XW; Qiao, BK; Jiang, ZY or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Photoredox-Catalyzed Addition of Carbamoyl Radicals to Olefins: A 1,4-Dihydropyridine Approach WOS:000539603800001 published article about VISIBLE-LIGHT; ELECTRON; PHOTOEXCITATION; ENERGY; STATE; ACIDS in [Cardinale, Luana; Konev, Mikhail O.; Jacobi von Wangelin, Axel] Univ Hamburg, Dept Chem, Martin Luther King Pl 6, D-20146 Hamburg, Germany in 2020.0, Cited 57.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Recommanded Product: 91-02-1

Functionalization with C1-building blocks are key synthetic methods in organic synthesis. The low reactivity of the most abundant C-1-molecule, carbon dioxide, makes alternative carboxylation reactions with CO2-surrogates especially important. We report a photoredox-catalyzed protocol for alkene carbamoylations. Readily accessible 4-carboxamido-Hantzsch esters serve as convenient starting materials that generate carbamoyl radicals upon visible light-mediated single-electron transfer. Addition to various alkenes proceeded with high levels of regio- and chemoselectivity.

Recommanded Product: 91-02-1. Welcome to talk about 91-02-1, If you have any questions, you can contact Cardinale, L; Konev, MO; von Wangelin, AJ or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem