Category: 91-02-1

Yu, Tao published the artcilePoly(ethylene glycol) dimethyl ether mediated oxidative scission of aromatic olefins to carbonyl compounds by molecular oxygen, Recommanded Product: Phenyl(pyridin-2-yl)methanone, the publication is RSC Advances (2021), 11(23), 13848-13852, database is CAplus and MEDLINE.

A simple and practical oxidative scission of aromatic olefins to carbonyl compounds R¹C(O)R₂ [R¹ = Ph, 4-MeC₆H₄, 4-FC₆H₄, etc., R² = Ph, 4-MeOC₆H₄, 4-ClC₆H₄, ect.] using O₂ as the sole oxidant with poly(ethylene glycol) di-Me ether as a benign solvent was developed. A wide range of monosubstituted, gem-disubstituted, 1,2-disubstituted, trisubstituted and tetrasubstituted aromatic olefins was successfully converted into the corresponding aldehydes and ketones in excellent yields even with gram-scale reaction. Some control experiments were also conducted to support a possible reaction pathway.

RSC Advances published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C6H5NO, Recommanded Product: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bhar, Kishalay published the artcileHigh temperature spin crossover behaviour of mononuclear bis-(thiocyanato)iron(II) complexes with judiciously designed bidentate N-donor Schiff bases with varying substituents, Safety of Phenyl(pyridin-2-yl)methanone, the publication is Dalton Transactions (2022), 51(24), 9302-9313, database is CAplus and MEDLINE.

THe authors present herein a family of mol. cis-[Fe^II(X-PPMA)₂(NCS)₂]·H₂O [4-X-N-(phenyl(pyridin-2-yl)methylene)aniline; X-PPMA; X = Cl (1), Br (2), and CH₃ (3)] complexes that exhibit spin crossover behavior above room temperature Judiciously designed bidentate N-donor Schiff bases of 2-benzoylpyridine and para-substituted anilines in combination with Fe(NCS)₂ were used for the synthesis of complexes 1–3. The relatively strong ligand field of the Schiff bases stabilizes the low spin state of iron(II) up to 300 K which is evident from magnetic measurements, room temperature Mossbauer spectra and crystallog. bond/angle distortion parameters. Interestingly, complexes 1–3 crystallize in a tetragonal system with either a P4₃2₁2 or P4₁2₁2 chiral space group from achiral building units due to the supramol. helical arrangements of mols. through intermol. (pyridine)C-H···C(NCS) interactions in the crystalline state. Complexes 1 and 2 exhibit complete, gradual and slightly irreversible spin crossover behavior in the temperature range of 300-500 K with equilibrium temperatures (T_1/2) 375 K (1) and 380 K (2). The spin state evolution of iron(II) in complexes 1 and 2 is monitored between 150 K and 450 K through variable temperature crystallog. studies in the warming mode. The structural data are in good agreement with the 94% (1) and 87% (2) high spin conversion of iron(II) at 450 K. At a high temperature (450 K), some minor irreversible ligand motion is noticed in complexes 1 and 2, in addition to a complete solvent loss that may induce the slight irreversibility of the spin crossover. On the other hand, complex 3 shows a complete and gradual spin crossover in the temperature range of 10-475 K with strong irreversible features. The equilibrium temperatures obtained upon first warming (T_1/2↑) and second cooling (T_1/2↓) are 375 K and 200 K, resp. In complex 3, the loss of a water mol. triggers strong deviations in the spin crossover behavior. Moreover, dehydrated complex 3 exhibits photoswitching LIESST effect with a relaxation temperature T(LIESST) = 60 K.

Dalton Transactions published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Safety of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wu, Zhao published the artcileAnti-Markovnikov hydro(amino)alkylation of vinylarenes via photoredox catalysis, Quality Control of 91-02-1, the publication is Nature Communications (2021), 12(1), 5956, database is CAplus and MEDLINE.

Herein, the application of this powerful catalytic manifold to address the hydroalkylation and hydroaminoalkylation of electronically diverse vinylarenes e.g., 1,1-diphenylethylene was presented. This reaction allows for generalized alkene hydroalkylation leveraging common alkyl radical precursors, such as organotrifluoroborate salts and carboxylic acids. Furthermore, utilizing easily accessible α-silyl amine reagents or tertiary amines directly, secondary and tertiary amine moieties can be installed onto monoaryl and diaryl alkenes to access valuable products. Thus, under a unified system, both hydroalkylation and hydroaminoalkylation of alkenes are achieved. The substrate scope is evaluated through 57 examples, the synthetic utility of the method is demonstrated, and preliminary mechanistic insights are presented.

Nature Communications published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C16H24BF4Ir, Quality Control of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Shukla, Satyendra Nath published the artcileNovel NNO pincer type Schiff base ligand and its complexes of Fe(IIl), Co(II) and Ni(II): Synthesis, spectroscopic characterization, DFT, antibacterial and anticorrosion study, Product Details of C12H9NO, the publication is Journal of Molecular Structure (2021), 130582, database is CAplus.

A novel NNO pincer type ligand (E)-N’-(phenyl(pyridin-2-yl)methylene)isonicotinohydrazide, PPMINH, was synthesized by condensation of 2-benzoyl pyridine and isonicotinylhydrazide. The ligand PPMINH on reaction with metal ions Fe(III), Co(II) and Ni(II) yielded six metal derivatives Different anal. tools like; Elemental analyses, ESI-MS, FTIR, molar conductivity, UV-spectra, magnetic susceptibility, NMR and EPR measurement were used. Theor. FTIR, ¹H NMR and ¹³C NMR of ligand and complex 6 exhibits quite a good correlation coefficient EPR spectrum of complex 6 at LNT suggests octahedral geometry around Ni(II). The ligand and complexes were screened for antibacterial activity. DFT was carried out to optimize the geometry of the ligand and complexes. The properties most relevant to their potential action as corrosion inhibitors was calculated all parameters of DFT from the inhibitor mol. to the metal atom. The corrosion inhibition effect of compounds on mild steel in an acidic medium was studied for 24, 48, 72 h using weight loss measurement.

Journal of Molecular Structure published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C18H17NO8, Product Details of C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Volpi, G. published the artcileFluorescent trifluoromethylated imidazo[1,5-a]pyridines and their application in luminescent down-shifting conversion, Category: pyridine-derivatives, the publication is Journal of Luminescence (2022), 118529, database is CAplus.

In the last few years, imidazo[1,5-a]pyridine derivatives have attracted growing attention due to their unique optical behaviors. Herein, a series of trifluoromethylated substituted imidazo[1,5-a]pyridine derivatives were synthesized and their optical properties investigated. Depending on the position of the trifluoromethylated substituents on the imidazo[1,5-a]pyridine nucleus, we were able to tune the quantum yields (Φ) both in acetonitrile solution (from 13% to 39%) and in the polymeric matrix (10%-58%) with a remarkable large Stokes shift. The investigated fluorophores were dispersed in a transparent polyurethane resin, providing a possible luminescent low-cost material for down-shifting conversion. An anal. based on the chem. structures and spectroscopic data, both in solution and polymeric medium, is reported to address the best strategies to optimize the photophys. properties and prevent aggregation. Finally, optimized polyurethane-based films prepared with compounds 2 and 3 were tested as a luminescent coating on a com. photodiode, enabling their technol. application.

Journal of Luminescence published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H20O6, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kanchanadevi, Sivaswamy published the artcileRuthenium(III) hydrazone complexes with triphenylphosphine/triphenylarsine co-ligands: Synthesis, DNA/BSA binding, antioxidative and cytotoxic activity, Recommanded Product: Phenyl(pyridin-2-yl)methanone, the publication is Inorganica Chimica Acta (2021), 120532, database is CAplus.

New ruthenium(III) complexes with (E)-3-methoxy-N’-(phenyl(pyridin-2-yl)methylene)benzohydrazide (HL) were synthesized and characterized by various physicochem. and spectroscopic methods. The ligand acted as a tridentate, monobasic chelating ligand with NNO donor sites in all the complexes. The x-ray crystal structure of one of the complexes, [Ru^III(L)(PPh₃)Cl₂] (1) demonstrated a distorted octahedral coordination geometry around the metal center. Interactions of these complexes with calf thymus-DNA (CT-DNA) assessed by absorption and emission spectroscopy revealed intercalative mode of binding. Bovine serum albumin (BSA) binding of the ligand and complexes studied by absorption spectroscopy, fluorescence and synchronous spectroscopic methods revealed that the compounds bind to BSA via static binding. Antioxidant study of the ligand and complexes showed significant antioxidant activity against DPPH radical. In addition, the in vitro cytotoxicity of the ligand and complexes against human breast cancer cell line (MCF-7) and human lung cancer cells (A-549) was assayed. The results showed higher cytotoxic activity with lower IC₅₀ values indicating their efficiency in killing the cancer cells even at low concentrations

Inorganica Chimica Acta published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Recommanded Product: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kanchanadevi, Sivaswamy published the artcileInvestigation of DNA/BSA binding and cytotoxic properties of new Co(II), Ni(II) and Cu(II) hydrazone complexes, Formula: C12H9NO, the publication is Inorganica Chimica Acta (2021), 120536, database is CAplus.

Two mononuclear complexes of Co(II) (1) and Ni(II) (2) and a chloro bridged binuclear copper(II) complex (3) of 2-benzoylpyridine-4-methoxybenzoylhydrazone have been synthesized in order to explore their biol. activities, such as DNA binding, protein-binding, antioxidant activity and anticancer activity. Anal. and spectroscopic techniques have been used to characterize the complexes. The mol. structures of 2 and 3 have been obtained by single crystal XRD. Interaction of the ligand and the complexes with calf thymus DNA (CT-DNA) has been explored by absorption and emission titrations, which revealed that the compounds interacted with CT-DNA through intercalation. Absorption titration and biol. studies revealed that the complexes interact with BSA through different binding modes to different extents. The radical scavenging ability of the ligand and the complexes was studied against DPPH radicals. The ligand and its metal complexes were tested for potential cytotoxicity towards human breast cancer (MCF-7) and lung cancer (A-549) cell lines.

Inorganica Chimica Acta published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Formula: C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Bing published the artcileAsymmetric Stepwise Reductive Amination of Aryl N-Heteroaryl Ketones with Benzyl Amines via Iridium Catalysis, SDS of cas: 91-02-1, the publication is Asian Journal of Organic Chemistry (2021), 10(11), 2950-2953, database is CAplus.

An asym. reductive amination of aryl N-heteroaryl ketones RC(O)R¹ (R = 2-methylphenyl, naphthalen-1-yl, 3,5-dimethoxyphenyl; R¹ = Me, pyridin-2-yl, quinolin-2-yl, etc.) with Benzyl Amines ArCH₂NH₂ (Ar = Ph, 2,6-dimethylphenyl) has been realized via one-pot two-step process, using p-toluenesulfonic acid and chiral iridium complexes as catalysts, a mixture of formic acid/triethylamine as a reductant. Twenty-three examples of chiral aryl N-heteroaryl methylamines (S)-RCH(R¹)NHCH₂Ar were obtained with good yields and up to 99% ee.

Asian Journal of Organic Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C3H6O2, SDS of cas: 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Al-Janabi, Ahmed S. M. published the artcileSynthesis, anti-bacterial evaluation, DFT study and molecular docking as a potential 3-chymotrypsin-like protease (3CLpro) of SARS-CoV-2 inhibitors of a novel Schiff bases, Formula: C12H9NO, the publication is Journal of Molecular Structure (2021), 129454, database is CAplus and MEDLINE.

New Schiff bases (L¹H) I (I), (L²H) II (II), (L³H) III (III) were synthesized by reaction of 2-benzoylpyridine with different amines (2-amino-6-chlorobenzothiazole, isonicotinohydrazide and N¹-(naphthalen-1-yl)ethane-1,2-diamine) and characterized by ¹H-NMR, ¹³C-NMR, IR mass spectroscopy and elemental anal. The compounds (I), (II) and (III) were assayed by the disk diffusion method for anti-bacterial against five pathogenic bacteria species (Staphylococcus aureus, Micrococcus luteus, Staphylococcus pyogenes, Bacillus subtilis, and E. coli). All prepared Schiff bases (I), (II) and (III) showed good activity compared to pos. control (streptomycin). Moreover the L³H showed the highest activity against S. aureus, and M. luteus than the other compounds and streptomycin. In addnl. mol. docking studies with 3-chymotrypsin-like protease (3CLpro), the essential enzyme for SARS-CoV-2 proliferation. The rest of compounds have shown promising results as 3CLpro inhibitors interacting with the active sites of the enzymes. Finally, DFT’s estimated electrostatic mol. potential results were used to illustrate the mol. docking findings. The DFT calculations showed that L³H has the highest dipole moment and electrophilicity index. Interestingly, L²H of the largest energy gap ΔE = 2.49 eV, there are several hydrophilic interactions that could facilitate the binding with the receptors. All of these parameters could be shared to significantly affect the protein sites of binding affinity with different extent.

Journal of Molecular Structure published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Formula: C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Liu, Yanjie published the artcileFeCl₂ Catalyzed Three-Component Reactions of Phospholes, Pyrrolidine, and Ketones (Aldehydes): Chemoselective Synthesis of 1-Phosphafulvenes, Quality Control of 91-02-1, the publication is Organic Letters (2021), 23(8), 2943-2947, database is CAplus and MEDLINE.

The authors have developed an unprecedented approach for the synthesis of transient 1-phosphafulvenes through three component reactions of phospholes. The generation of 1-phosphafulvenes was demonstrated by in situ [6 + 4] cycloaddition with 2H-phospholes and [6 + 6] self-dimerization. The [6 + 4] and [6 + 6] reaction pathway could be modulated by the starting ketones and aldehydes. The construction of 1-phosphafulvenes is illustrated by a proposed mechanism combining nucleophilic addition of phospholide to the iminium or isomerized azomethine ylide and a [1,5]-shift of phosphole.

Organic Letters published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Quality Control of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem