Category: 910543-72-5

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 910543-72-5, name is 3-Amino-5-bromo-1-methylpyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows. Formula: C6H7BrN2O

To a solution of (6-Chloro-pyridin-3-yl)-(4-methyl-piperazin-l-yl)-methanone (2.0Og, 7.46 mmol) in 10 mL dimethylformamide was added 3-Amino-5-bromo-l -methyl- lH-pyridin-2-one (1.8Og, 8.95mmol) and sodium hydiride (537mg, 22.4mmol). After stirring for 18 hours, this was quenched with water. This was extracted with ethylacetate. The ethylacetate layer was dired over anhydrous sodium sulfate, concentrated in vacuo, and purified by flash chromatography (gradient elution 0 to 5% methanol/DCM) to yield 5-Bromo-l-methyl-3-[5-(4-methyl- piperazine-l-carbonyl)-pyridin-2-ylamino]-lH-pyridin-2-one (900mg, 1.94mmol). MS (ESI) 406.0 (M+H)+.

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Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2009/98144; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 910543-72-5 , The common heterocyclic compound, 910543-72-5, name is 3-Amino-5-bromo-1-methylpyridin-2(1H)-one, molecular formula is C6H7BrN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

vii. The compound 9 (1.0 eq) was dissolved in DCM, then methanol(0.01eq) and glacial acetic acid(0.01eq) were added to facilitate dissolution. After stirring a little while, the HCHO or CH3CHO liquid was added slowly. The reaction mixture was stirred at room temperature for 0.5 hour. After the reaction was completed by TLC detection, Na(CN)BH3 (3.0 eq) was added into the reaction mixture, the reaction lasted for 1 hour. Then the mixture were evaporated under reduced pressure to remove the solvent and the residual methanol, and the obtained crude product was extracted with EA/H2O/brine, dried. Intermediate 10 was gained. The yield was 60%.

The synthetic route of 910543-72-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rong, Juan; Feng, Zhan-Zhan; Shi, Yao-Jie; Ren, Jing; Xu, Ying; Wang, Ning-Yu; Xue, Qiang; Liu, Kun-Lin; Zhou, Shu-Yan; Wei, Wei; Yu, Luo-Ting; Bioorganic and Medicinal Chemistry Letters; vol. 29; 19; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 910543-72-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 910543-72-5, name is 3-Amino-5-bromo-1-methylpyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 3-amino-5-bromo-1 -methyl-1 ,2-dihydropyridin-2-one (406.08 mg, 2.000 mmol, 1 equiv) and Et3N (1 619.05 mg, 16.000 mmol, 8 equiv) in DCM (5 ml_) was added acetyl chloride (628.00 mg, 8.00 mmol, 4 equiv) dropwise at 0 degrees C. The mixture was stirred for 1 hour at room temperature. Then the solvent was evaporated, and the residue was purified by flash chromatography, eluted with EtOAc/PE (0-100%) to give the A/-(5-bromo-1 -methyl-2-oxo-1 ,2-dihydropyridin-3-yl)acetamide (487 mg, 99.36%). LCMS (ESI) m/z: [M+H]+ = 245.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 910543-72-5, 3-Amino-5-bromo-1-methylpyridin-2(1H)-one.

Reference:
Patent; FOGHORN THERAPEUTICS INC.; ZHOU, Qianhe; BOCKER, Michael; MILLAN, David, Simon; CHAN, Ho, Man; SOARES, Luis; NETHERTON, Matthew, Russell; RUPPEL, Sabine, K.; YANG, Zhaoxia; LOWE, Jason, T.; BRUCELLE, Francois; (220 pag.)WO2019/152440; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem