Category: 910656-00-7

Adding a certain compound to certain chemical reactions, such as: 910656-00-7, 4-Amino-N-methylnicotinamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C7H9N3O, blongs to pyridine-derivatives compound. HPLC of Formula: C7H9N3O

4-Amino-Lambda/-methyl-3-pyridinecarboxamide (200 mg; may be prepared as described in intermediate 121 ) was dissolved in DMF (20.00 ml_). DMAP (8.08 mg), N,N- diisopropylethylamine (0.462 ml.) and chloroacetyl chloride (0.212 ml.) were added at room temperature under stirring. The mixture was heated in the microwave for 10 min at100 0C. The mixture was diluted with EtOAc (10 ml) and washed with water and brine ( x3). Organics were dried over sodium sulphate, filtered and the solvent was evaporated to afford the crude product that was purified by silica chromatography to afford the title compound (100 mg, 0.395 mmol). m/z [M+H]+: 228.1 / 230.1. Retention time 0.44 min (LC/MS method 3).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,910656-00-7, 4-Amino-N-methylnicotinamide, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; BLUNT, Richard; EATHERTON, Andrew John; GARZYA, Vincenzo; HEALY, Mark Patrick; MYATT, James; PORTER, Roderick Alan; WO2011/12622; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 910656-00-7, 4-Amino-N-methylnicotinamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C7H9N3O, blongs to pyridine-derivatives compound. HPLC of Formula: C7H9N3O

4-Amino-Lambda/-methyl-3-pyridinecarboxamide (200 mg; may be prepared as described in intermediate 121 ) was dissolved in DMF (20.00 ml_). DMAP (8.08 mg), N,N- diisopropylethylamine (0.462 ml.) and chloroacetyl chloride (0.212 ml.) were added at room temperature under stirring. The mixture was heated in the microwave for 10 min at100 0C. The mixture was diluted with EtOAc (10 ml) and washed with water and brine ( x3). Organics were dried over sodium sulphate, filtered and the solvent was evaporated to afford the crude product that was purified by silica chromatography to afford the title compound (100 mg, 0.395 mmol). m/z [M+H]+: 228.1 / 230.1. Retention time 0.44 min (LC/MS method 3).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,910656-00-7, 4-Amino-N-methylnicotinamide, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; BLUNT, Richard; EATHERTON, Andrew John; GARZYA, Vincenzo; HEALY, Mark Patrick; MYATT, James; PORTER, Roderick Alan; WO2011/12622; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem