Category: 912934-77-1

Synthetic Route of 912934-77-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 912934-77-1, name is 6-Bromopyridine-2-sulfonyl chloride, molecular formula is C5H3BrClNO2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of Compound 12 (0.079 g, 0.780 mmol) and TEA (0.24 mL, 1.715 mmol) in DCM (5 mL) cooled to 0 C was added Compound 11 (0.20 g, 0.780 mmol). The mixturewas stirred at 0 C for 1 h, quenched with water and extracted with DCM. The organic extracts were dried over Mg504 and concentrated to give Compound 13 as an orange oil that was used in subsequent steps without purification (0.21 g, yield 84%): LC/MS: nz/z= 322.8 [M+Hf (Calc: 321.2).

According to the analysis of related databases, 912934-77-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PURDUE PHARMA L.P.; TAFESSE, Laykea; PARK, Jae, Hyun; WO2015/123398; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 912934-77-1, Adding some certain compound to certain chemical reactions, such as: 912934-77-1, name is 6-Bromopyridine-2-sulfonyl chloride,molecular formula is C5H3BrClNO2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 912934-77-1.

n-Butyl magnesium chloride (2.0 M in THF, 2.25 ml, 45 mmol) was added to a stirred solution of w-butyl lithium (1.6 M in hexanes, 5.56 ml, 8.9 mmol) at 0C under argon. After 10 minutes at 0C the mixture was cooled to -10C. A solution of 2,6-dibromopyridine (3.0 g, 12.7 mmol) in toluene (35 ml) was added over 10 minutes and the mixture was stirred at -10 for 2 hours. After cooling to -40C, sulfur dioxide gas was bubbled into the mixture for 5 minutes and the reaction was stirred at -40C for 30 minutes. Sulfuryl chloride (1.1 ml, 13.6 mmol) was added and the mixture was allowed to warm to room temperature. The resulting mixture was added over 5 minutes to a stirred mixture of phenol (1.25 g, 13.3 mmol) and triethylamine (7.0 ml, 50.6 mmol) in acetonitrile (30 ml) at 0C. The mixture was stirred at 0C for 30 minutes and then at room temperature for 2 hours. The mixture was concentrated in vacuo and the residue partitioned between ethyl acetate and dilute sodium bicarbonate solution. The organic phase was washed with water, brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to afford the title product (D7). MS(ES+) m/e 314/316 [M+H]+.

According to the analysis of related databases, 912934-77-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/10629; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 912934-77-1, Adding some certain compound to certain chemical reactions, such as: 912934-77-1, name is 6-Bromopyridine-2-sulfonyl chloride,molecular formula is C5H3BrClNO2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 912934-77-1.

To a solution of compound from Example 1 step e (142 mg, 0.5 mmol) in pyridine (2 mL) was added 6-bromopyridine-2-sulfonyl chloride (128 mg, 0.5 mmol). The mixture was stirred at rt overnight. After evaporated most of the pyridine, the residue was purified by silica gel column chromatography to obtain the desired product (120 mg, 48%) as a pale-yellow foam which will be used directly for the next step.

According to the analysis of related databases, 912934-77-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; YU, Jianming; SHOOK, Brian, C.; BLAISDELL, Thomas, P.; KIM, In, Jong; PANARESE, Joseph; MCGRATH, Kevin; NEGRETTI-ENMANUELLI, Solymar; OR, Yat, Sun; (301 pag.)WO2017/123884; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 912934-77-1, 6-Bromopyridine-2-sulfonyl chloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 6-Bromopyridine-2-sulfonyl chloride, blongs to pyridine-derivatives compound. name: 6-Bromopyridine-2-sulfonyl chloride

Step 1-Preparation of 1-((6-bromopyridin-2-yl)sulfonyl)pyrrolidine-3-carbonitrile, 64 To 6-bromopyridine-2-sulfonyl chloride (100 mg, 0.39 mmol) was added pyrrolidine-3-carbonitrile (37.48 mg, 0.39 mmol) and dichloromethane (2 ml). The reaction was allowed to stir at room temperature for 30 minutes. The reaction was quenched with saturated sodium bicarbonate solution and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, filtered and concentrated to dryness to provide 1-((6-bromopyridin-2-yl)sulfonyl)pyrrolidine-3-carbonitrile 64. This material was used in the next step without further purification.

The synthetic route of 912934-77-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Plexxikon Inc.; Wu, Guoxian; Wu, Jeffrey; Chan, Katrina; Dong, Ken; Ewing, Todd; Ibrahim, Prabha N.; Lin, Jack; Spevak, Wayne; Zhang, Ying; (150 pag.)US2017/158690; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem