Category: 914349-75-0

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 914349-75-0, name is 5-(4-Fluorophenyl)picolinonitrile, molecular formula is C12H7FN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 914349-75-0

5-(4-fluorophenyl)picolinonitrile (1.5 g) was dissolved in dry THF (20 mL) and cooled in an ethanol / CO2 bath. 1 M LiAlH4 in THF (20 mL) was added and the mixture stirred at below room temperature for 2 h. The reaction was quenched by the dropwise addition of 1 : 10 water : THF (20 mL), diluted with ethyl acetate, stirred with 1 M NaOH and the organic phase decanted, washed with 1 M NaOH, brine and dried. Evaporation gave the title compound as an amorphous yellow solid, used immediately and without further purification.

With the rapid development of chemical substances, we look forward to future research findings about 914349-75-0.

Reference:
Article; Greig, Iain R.; Baillie, Gemma L.; Abdelrahman, Mostafa; Trembleau, Laurent; Ross, Ruth A.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 18; (2016); p. 4403 – 4407;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 914349-75-0, name is 5-(4-Fluorophenyl)picolinonitrile, molecular formula is C12H7FN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 914349-75-0

5-(4-fluorophenyl)picolinonitrile (1.5 g) was dissolved in dry THF (20 mL) and cooled in an ethanol / CO2 bath. 1 M LiAlH4 in THF (20 mL) was added and the mixture stirred at below room temperature for 2 h. The reaction was quenched by the dropwise addition of 1 : 10 water : THF (20 mL), diluted with ethyl acetate, stirred with 1 M NaOH and the organic phase decanted, washed with 1 M NaOH, brine and dried. Evaporation gave the title compound as an amorphous yellow solid, used immediately and without further purification.

With the rapid development of chemical substances, we look forward to future research findings about 914349-75-0.

Reference:
Article; Greig, Iain R.; Baillie, Gemma L.; Abdelrahman, Mostafa; Trembleau, Laurent; Ross, Ruth A.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 18; (2016); p. 4403 – 4407;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem