Category: 914358-73-9

Electric Literature of 914358-73-9, Adding some certain compound to certain chemical reactions, such as: 914358-73-9, name is 5-Bromo-2-methylpyridin-3-amine,molecular formula is C6H7BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 914358-73-9.

A mixture of 4.00 g (21.4 mmol) C-3, 4.3 mL (32 mmol) 2,4-difluorobenzenesulfonyl chloride, 5.2 mL (64 mmol) pyridine and 50 mL DCM is stirred at RT for 5 h. After completion of the reaction, the solvent is removed under reduced pressure, the crude product is taken up in 50 mL water and extracted twice with 100 mL DCM. The combined organic layers are dried over MgS04 and the solvent is removed under reduced pressure. The crude product can be used without further purification. Yield: 7.88 g (91%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 914358-73-9, 5-Bromo-2-methylpyridin-3-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WUNBERG, Tobias; VEEN, Van Der, Lars; KRAEMER, Oliver; WO2012/101186; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 914358-73-9, 5-Bromo-2-methylpyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 914358-73-9, blongs to pyridine-derivatives compound. Computed Properties of C6H7BrN2

To a mixture of 3-amino-5-bromo-2-methylpyridine (8.3 g) and potassium acetate (5.2 g) in chloroform (200 mL) was added acetic anhydride (16.7 mL) at room temperature and the mixture let stirred at room temperature for 3 hours and then heated to reflux for an additional 2 hours, After cooling the mixture to room temperature, was added isoamylnitrite (11.9 mL) and 18-crown-6-ether (1 g) and the mixture heated to reflux for 26 hours. After cooling to room temperature, the mixture was filtered through a plug of Celite. The filtrate was concentrated under reduced pressure to yield a residue that was treated with a suspension of potassium carbonate (10 g) in a mixture of methanol (150 mL) and water (10 mL) at 0 C. for 2 hours. The mixture was concentrated under reduced pressure to yield a residue that was extracted with EA and washed with water. The organic layer was dried over sodium sulfate, filtered and concentrated under reduced pressure to give a residue that was triturated with a mixture of DCM and heptane to give 6-bromo-1H-pyrazolo[4,3-b]pyridine (6.85 g, 75% overall yield from 10 g of 5-bromo-2-methyl-3-nitropyridine). MS (ES): M/Z [M+H]=198. 1H NMR: (400 MHz, DMSO-d6): 8.33 (br. s, 2H), 8.57 (d, J=1.7 Hz, 1H), 13.47 (br. s, 1H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,914358-73-9, its application will become more common.

Reference:
Patent; Soll, Mark David; Hir de Fallois, Loic Patrick Le; Huber, Scot Kevin; Lee, Hyoung Ik; Wilkinson, Douglas Edward; Jacobs, Robert Toms; Beck, Brent Christopher; US2010/125089; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 914358-73-9, name is 5-Bromo-2-methylpyridin-3-amine, molecular formula is C6H7BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C6H7BrN2

c) N-(5-bromo-2-methyl-3-pyridinyl)cyclopropanesulfonamide; In an oven dried round bottom flask under nitrogen, a solution of 5-bromo-2-methyl-3-pyridinamine (150 mg, 0.802 mmol) in anhydrous pyridine (4 mL) was treated with cyclopropanesulfonyl chloride (0.098 mL, 0.962 mmol) and the resultant reaction mixture stirred at room temperature for 18.75 hours. The reaction mixture was concentrated in vacuo, diluted with ethyl acetate (100 mL) and water (30 mL), neutralized with saturated ammonium chloride (aq) and the product extracted into the organic layer. The aqueous layer was back-extracted with ethyl acetate (40 mL) and the combined organic layers washed with brine (50 mL), dried over magnesium sulfate, filtered and concentrated in vacuo to give a yellow-brown solid. Purification by silica gel chromatography (0-50% ethyl acetate in hexanes) provided the title compound (218 mg, 93%) as an off-white solid. MS (ES)+ m/e 290.9, 292.8 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 914358-73-9.

Reference:
Patent; CHAUDHARI, Amita; DHANAK, Dashyant; DONATELLI, Carla Ann; FAITG, Thomas H.; FENG, Yanhong; KNIGHT, Steven David; PARRISH, Cynthia A.; RALPH, Jeffrey M.; US2008/293706; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem