Category: 915107-31-2

Synthetic Route of 915107-31-2, Adding some certain compound to certain chemical reactions, such as: 915107-31-2, name is Methyl 6-chloro-5-methoxynicotinate,molecular formula is C8H8ClNO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 915107-31-2.

Step 3. Preparation of methyl 5-methoxy-6-(4-methyl-1 H-imidazol-1 – yl)nicotinate (C7). Methyl 6-chloro-5-methoxynicotinate (C6) (185 mg, 0.918 mmol) was combined with 4-methyl-1 H-imidazole (148 mg, 1 .80 mmol) and cesium fluoride (273 mg, 1 .80 mmol). After the mixture was purged with nitrogen, dimethyl sulfoxide (3.0 mL) was added and the mixture was heated at 1 10 C for 1 .25 hours. After cooling to room temperature, the reaction was combined with an identical reaction carried out on 0.15 mmol of substrate, and poured into aqueous sodium bicarbonate solution (25 mL). After extraction with ethyl acetate (3 x 25 mL), the organic layers were combined, washed with aqueous sodium bicarbonate solution (25 mL), washed with brine (25 mL), dried over magnesium sulfate and concentrated in vacuo. Chromatography on silica (Gradient: 0% to 40% [9:1 ethyl acetate: 2 M ammonia in methanol] in ethyl acetate), afforded the title product. Yield: 148 mg, 0.599 mmol, 56%. LCMS m/z 248.5 (M+1 ). 1 H NMR (400 MHz, CDCI3) delta 2.30 (d, J=0.9 Hz, 3H), 3.98 (s, 3H), 4.04 (s, 3H), 7.63 (m, 1 H), 7.93 (d, 1 .7 Hz, 1 H), 8.47 (d, J=1 .1 Hz, 1 H), 8.68 (d, J=1.8 Hz, 1 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 915107-31-2, Methyl 6-chloro-5-methoxynicotinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER INC.; AM ENDE, Christopher William; JOHNSON, Douglas Scott; O’DONNELL, Christopher John; PETTERSSON, Martin Youngjin; SUBRAMANYAM, Chakrapani; WO2011/48525; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 915107-31-2, name is Methyl 6-chloro-5-methoxynicotinate. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 915107-31-2

To a solution of 6-chloro-5-methoxynicotinic acid methyl ester (1.3 g, 6.4 mmol) in MeOH (4 mL) at 25 C. was added 10% NaOH aqueous solution (19.3 mmol). The reaction was stirred for 24 h, then placed into an ice water bath and acidified with 2M HCl until pH=2 was achieved. The flask was then placed into a refrigerator for 3 h. The white precipitate was filtered off and rinsed with cold H2O. The solid was dissolved in acetone, dried over MgSO4 and concentrated to furnish the product 6-chloro-5-methoxynicotinic acid as a yellow solid (0.895 g, 74%); 1H NMR (400 MHz, CDCl3) delta 8.45 (d, 1H), 7.66 (d, 1H), 3.83 (s, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 915107-31-2, Methyl 6-chloro-5-methoxynicotinate.

Reference:
Patent; Zhu, Yuanming; Loso, Michael R.; Nugent, Benjamin M.; Huang, Jim X.; Rogers, Richard B.; US2008/108667; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 915107-31-2, name is Methyl 6-chloro-5-methoxynicotinate. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 915107-31-2

To a solution of 6-chloro-5-methoxynicotinic acid methyl ester (1.3 g, 6.4 mmol) in MeOH (4 mL) at 25 C. was added 10% NaOH aqueous solution (19.3 mmol). The reaction was stirred for 24 h, then placed into an ice water bath and acidified with 2M HCl until pH=2 was achieved. The flask was then placed into a refrigerator for 3 h. The white precipitate was filtered off and rinsed with cold H2O. The solid was dissolved in acetone, dried over MgSO4 and concentrated to furnish the product 6-chloro-5-methoxynicotinic acid as a yellow solid (0.895 g, 74%); 1H NMR (400 MHz, CDCl3) delta 8.45 (d, 1H), 7.66 (d, 1H), 3.83 (s, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 915107-31-2, Methyl 6-chloro-5-methoxynicotinate.

Reference:
Patent; Zhu, Yuanming; Loso, Michael R.; Nugent, Benjamin M.; Huang, Jim X.; Rogers, Richard B.; US2008/108667; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 915107-31-2 ,Some common heterocyclic compound, 915107-31-2, molecular formula is C8H8ClNO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

3- (4- (Trifluoromethyl) phenyl) pyrrolidine (210 mg, 0.98 mmol) , methyl 6-chloro-5-methoxynicotinate (192 mg, 0.95 mmol) and K 2CO 3 (386 mg, 2.79 mmol) were dissolved in DMSO (6 mL) , and the mixture was heated to 100 and stirred for 5 h. The reaction mixture was cooled to room temperature, diluted with EtOAc (60 mL) , and washed with water (15 mL) and saturated aqueous NaCl (15 mL×5) successively, dried over anhydrous Na 2SO 4 , and concentrated in vacuo to give a crude product, which was purified by silica-gel column chromatography (eluent: PET/EtOAc (v/v) = 5/1) to give a light yellow solid (280 mg, 75%) . [0690] MS (ESI, pos. ion) m/z = 381.2 [M+1] +.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,915107-31-2, its application will become more common.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; LIU, Bing; ZHONG, Xue; WANG, Feng; LI, Xuke; HE, Wei; PAN, Wei; HUANG, Jiuzhong; ZHANG, Yingjun; ZHENG, Changchun; (0 pag.)WO2020/11147; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 915107-31-2, name is Methyl 6-chloro-5-methoxynicotinate. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of Methyl 6-chloro-5-methoxynicotinate

Example 3. 3-Cyano-1-[6-(3,3-difluoro-pyrrolidin-1-yl)-5-methoxy-pyridin-3-ylmethyl]-1 H-pyrazole-4-carboxylic acid {l-amino-isoquinolin-6-ylmethyl)-amide {6-Chloro-S-methoxy-pyridin-3-yl)-methanol To a stirred solution of 6-chloro-5-methoxy-nicotinic acid methyl ester (0.5 g, 2.48 mmol) in anhydrous THF (20 mL) cooled to 0 C under nitrogen, was added UAIH4 (104 mg, 2.73 mmol). The reaction was allowed to warm to rt. The reaction was cooled to 0 C and quenched with water. Potassium sodium tartrate (Rochelle’s salt) was added and the mixture was filtered through Celite and washed with EtOAc (20 mL). The filtrate was separated and the aqueous extracted with EtOAc (20 mL). The combined organic layers were washed with brine (50 ml), dried over MgSO and the solvent removed in vacuo. The residue was purified by automated FC (EtOAc/petrol) to afford (6-chloro-5-methoxy-pyridin-3-yl)- methanol (710 mg, 82% yield) [MuEta]+ = 173.7

With the rapid development of chemical substances, we look forward to future research findings about 915107-31-2.

Reference:
Patent; KALVISTA PHARMACEUTICALS LIMITED; SMITH, Alun John; NOVAK, Andrew Richard; EVANS, David Michael; EDWARDS, Hannah Joy; STOCKS, Michael John; DAVIE, Rebecca Louise; MARSH, Sally Louise; HODGSON, Simon Teanby; (0 pag.)WO2016/83816; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 915107-31-2 ,Some common heterocyclic compound, 915107-31-2, molecular formula is C8H8ClNO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

3- (4- (Trifluoromethyl) phenyl) pyrrolidine (210 mg, 0.98 mmol) , methyl 6-chloro-5-methoxynicotinate (192 mg, 0.95 mmol) and K 2CO 3 (386 mg, 2.79 mmol) were dissolved in DMSO (6 mL) , and the mixture was heated to 100 and stirred for 5 h. The reaction mixture was cooled to room temperature, diluted with EtOAc (60 mL) , and washed with water (15 mL) and saturated aqueous NaCl (15 mL×5) successively, dried over anhydrous Na 2SO 4 , and concentrated in vacuo to give a crude product, which was purified by silica-gel column chromatography (eluent: PET/EtOAc (v/v) = 5/1) to give a light yellow solid (280 mg, 75%) . [0690] MS (ESI, pos. ion) m/z = 381.2 [M+1] +.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,915107-31-2, its application will become more common.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; LIU, Bing; ZHONG, Xue; WANG, Feng; LI, Xuke; HE, Wei; PAN, Wei; HUANG, Jiuzhong; ZHANG, Yingjun; ZHENG, Changchun; (0 pag.)WO2020/11147; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 915107-31-2, name is Methyl 6-chloro-5-methoxynicotinate. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of Methyl 6-chloro-5-methoxynicotinate

Example 3. 3-Cyano-1-[6-(3,3-difluoro-pyrrolidin-1-yl)-5-methoxy-pyridin-3-ylmethyl]-1 H-pyrazole-4-carboxylic acid {l-amino-isoquinolin-6-ylmethyl)-amide {6-Chloro-S-methoxy-pyridin-3-yl)-methanol To a stirred solution of 6-chloro-5-methoxy-nicotinic acid methyl ester (0.5 g, 2.48 mmol) in anhydrous THF (20 mL) cooled to 0 C under nitrogen, was added UAIH4 (104 mg, 2.73 mmol). The reaction was allowed to warm to rt. The reaction was cooled to 0 C and quenched with water. Potassium sodium tartrate (Rochelle’s salt) was added and the mixture was filtered through Celite and washed with EtOAc (20 mL). The filtrate was separated and the aqueous extracted with EtOAc (20 mL). The combined organic layers were washed with brine (50 ml), dried over MgSO and the solvent removed in vacuo. The residue was purified by automated FC (EtOAc/petrol) to afford (6-chloro-5-methoxy-pyridin-3-yl)- methanol (710 mg, 82% yield) [MuEta]+ = 173.7

With the rapid development of chemical substances, we look forward to future research findings about 915107-31-2.

Reference:
Patent; KALVISTA PHARMACEUTICALS LIMITED; SMITH, Alun John; NOVAK, Andrew Richard; EVANS, David Michael; EDWARDS, Hannah Joy; STOCKS, Michael John; DAVIE, Rebecca Louise; MARSH, Sally Louise; HODGSON, Simon Teanby; (0 pag.)WO2016/83816; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 915107-31-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 915107-31-2, name is Methyl 6-chloro-5-methoxynicotinate, molecular formula is C8H8ClNO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of 6-chloro-5-methoxy-nicotinic acid methyl ester (0.5g, 2.48mmol) in anhydrous THF (20mL) cooled to 0 C under nitrogen, LiAIH4 (104mg, 2.728mmol) was added. The reaction was allowed to warm to rt for 2 hrs. The reaction was cooled to 0 C and quenched with water (5mL). Potassium sodium tartrate ( ochelle’s salt) was added to help break up the suspension. The mixture was filtered through Celite, washing well with water (20mL) and ethyl acetate (lOOmL). The filtrate was collected and the layers separated. The aqueous extracted with ethyl acetate (3 x 20mL). The combined organic layers were washed with brine (50mL), dried over MgS04 and the solvent removed in vacuo. The crude was purified by flash chromatography (silica) eluting in step gradients up to 40% Pet. Ether, 60% ethyl acetate. Pure fractions were concentrated affording the title compound (6- chloro-5-methoxy-pyridin-3-yl)-methanol as a white solid (360mg, 2.074mmol, 84% yield). [M+H]+ = 174

According to the analysis of related databases, 915107-31-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KALVISTA PHARMACEUTICALS LIMITED; DAVIE, Rebecca Louise; EDWARDS, Hannah Joy; EVANS, David Michael; HODGSON, Simon Teanby; MILLER, Iain; NOVAK, Andrew Richard; SMITH, Alun John; STOCKS, Michael John; WO2014/188211; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 915107-31-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 915107-31-2, name is Methyl 6-chloro-5-methoxynicotinate. This compound has unique chemical properties. The synthetic route is as follows.

Methyl 6-bromo-5-methoxynicotinate To a solution of 6-chloro-5-methoxypyridine-3-carboxylate (850 mg, 4.22 mmol) in toluene (50 mL) was added POBr3 (2.9 g, 10.37 mmol) at room temperature. The resulting solution was then stirred for 16 h at 90 C., cooled to room temperature and diluted with water (30 mL). The resulting mixture was extracted with ethyl acetate (60 mL*3). The organic phases were combined, washed with brine and dried over sodium sulfate. The solvent was removed under reduced pressure and the residue was purified by flash chromatography eluting with ethyl acetate in hexane (0% to 100% gradient) to yield methyl 6-bromo-5-methoxypyridine-3-carboxylate as off-white solid (800 mg, 116%). MS: m/z=246.0 [M+H]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 915107-31-2, Methyl 6-chloro-5-methoxynicotinate.

Reference:
Patent; Merck Patent GmbH; SHERER, Brian A.; KARRA, Srinivasa; XIAO, Yufang; (407 pag.)US2016/376283; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem