Adding a certain compound to certain chemical reactions, such as: 918145-29-6, 3-Bromo-6-chloro-2,4-dimethylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 918145-29-6, blongs to pyridine-derivatives compound. Safety of 3-Bromo-6-chloro-2,4-dimethylpyridine
Under N2, to a solution of 3-bromo-2,4-dimethyl-6-chloropyridine (4.40 g, 20.0 mmol) in anhydrous Et2O (80 mL), cooled at -78 0C, was added tert-BvLi (1.7 M in pentane, 14.0 mL, 24.0 mmol) slowly, forming a yellow suspension. After addition the mixture was stirred at that temperature for 15 min, and then anhydrous DMF (4.0 mL) was added. After the mixture was stirred at -78 0C for 30 min, it was brought to room temperature and stirred for another 1/2 h. Aqueous work-up and purification by flash chromatography on silica gel (EtOAc/hexanes, 1:4 in v/v) afforded 6-chloro-2,4-dimethylpyridine-3-carboxaldehyde as a pale yellow solid (2.00 g, 60%). 1H NMR (CDCl3) delta 2.60 (s, 3H), 2.81 (s, 3H), 7.11 (s, IH), 10.57 (s, IH).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,918145-29-6, its application will become more common.
Reference:
Patent; ANORMED INC.; WO2007/22371; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem