Category: 92914-74-4

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 92914-74-4, name is Isoxazolo[5,4-b]pyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 92914-74-4

General procedure: To a solution of 3-aminoisoxazolo[5,4-b]pyridine(1) (1.35 g, 0.01 mol) in tetrahydrofurane (100mL) a few drops of pyridine and benzoyl chloride or4-bromobenzoyl chloride or 4-chlorobenzoyl chloridewas added. The reaction mixture was heatedunder reflux while being stirred in the microwavereactor in an aluminum bath at 60-65OC for 15 min.(3 5 min. with 5 min. breaks) at microwave powerP = 240 W. The solvent was removed under reducedpressure. The residue obtained was triturated withwater, filtered, dried and crystallized from ethanol.

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Reference:
Article; Por?ba, Krystyna; Pawlik, Krzysztof; Rembacz, Krzysztof P.; Kurowska, Ewa; Matuszyk, Janusz; D?ugosz, Anna; Acta poloniae pharmaceutica; vol. 72; 4; (2015); p. 727 – 735;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 92914-74-4, Adding some certain compound to certain chemical reactions, such as: 92914-74-4, name is Isoxazolo[5,4-b]pyridin-3-amine,molecular formula is C6H5N3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 92914-74-4.

Synthesis of exemplary compound 5: N-(1-(4-(Trifluoromethylthio)phenyl)-ethypisoxazolo[5,4-b]pyridin-3-amine 484 mg (2.2 mmol) of 4′-(trifluoromethylthio)acetophenone were added to a solution of 270 mg (2.0 mmol) of isoxazolo[5,4-b]pyridin-3-amine (intermediate VX001) in DCM (20 ml), and the mixture was stirred for 1 h at RT. 958 mul (6.0 mmol) of triethylsilane and 446 mul (6.0 mmol) of TFA were then added, and the reaction solution was stirred for 7 d at 60 C. After cooling to RT, the mixture was rendered basic with a sat. aq. NaHCO3 soln. The phases were separated, and the aqueous phase was again extracted with DCM. The combined organic phases were dried over Na2SO4, filtered and concentrated in vacuo. CC (EA/hexane 1:1) of the residue yielded 328 mg (1.0 mmol, 48%) of N-(1-(4-(trifluoromethylthio)phenyl)ethyl)-isoxazolo[5,4-b]pyridin-3-amine. MS: m/z 340.1 [M+H]+.

According to the analysis of related databases, 92914-74-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GRUNENTHAL GMBH; US2010/234419; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem