92992-85-3 | Page 2 of 3 | Pyridine-derivatives

Introduction of a new synthetic route about 92992-85-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,92992-85-3, its application will become more common.

Reference of 92992-85-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 92992-85-3 as follows.

To 2-bromo-3,5-dimethylpyridine (204 muL) were added (R)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester (350 muL),tris(dibenzylideneacetone)dipalladium(0)(73.8 mg),rac-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (100.4 mg),tert-butoxy sodium (232.4 mg) and toluene (4 mL) and the mixture was stirred at 120c for 7 hr. The reaction mixture was cooled and filtered through celite. The filtrate was concentrated and the obtained residue was purified by column chromatography (hexane:ethyl acetate)to give the title compound (459 mg). MS(APCI)m/z:292 (M+H)+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,92992-85-3, its application will become more common.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; ISHIBUCHI, Seigo; SARUTA, Kunio; HAMADA, Maiko; MATOBA, Nobuatsu; MATSUDAIRA, Tetsuji; SEKI, Maki; TARAO, Akiko; HONJO, Takashi; OGATA, Shingo; KAWATA, Atsushi; MOROKUMA, Kenji; FUJIE, Naoto; AOYAMA, Yukio; (251 pag.)EP3321256; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Extended knowledge of 92992-85-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,92992-85-3, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 92992-85-3, 2-Bromo-3,5-dimethylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 92992-85-3, blongs to pyridine-derivatives compound. Quality Control of 2-Bromo-3,5-dimethylpyridine

To 2-bromo-3,5-dimethylpyridine (10.26 g) were added (S)-1-(tert-butoxycarbonyl)-3-aminopyrrolidine (10.27 g),tris(dibenzylideneacetone)dipalladium(0)(505 mg),2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (1 g),sodium tert-butoxide (7.24 g) and toluene (180 mL) and the mixture was stirred at 80c for 3 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was concentrated under reduced pressure and the obtained residue was purified by column chromatography (hexane:ethyl acetate). The solvent was evaporated,ethyl acetate (50 mL),4N hydrogen chloride/1,4-dioxane solution (50 mL) and methanol (10 mL) were added to the obtained residue,and the mixture was stirred at room temperature for 2.5 hr. To the reaction mixture was added diethyl ether,and the supernatant was removed by decantation. To the obtained residue was added ethyl acetate/ethanol,and the precipitate was collected by filtration to give the title compound (11.9 g). MS(ESI)m/z:192(M+H)+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,92992-85-3, its application will become more common.

The origin of a common compound about 2-Bromo-3,5-dimethylpyridine

According to the analysis of related databases, 92992-85-3, the application of this compound in the production field has become more and more popular.

Application of 92992-85-3, Adding some certain compound to certain chemical reactions, such as: 92992-85-3, name is 2-Bromo-3,5-dimethylpyridine,molecular formula is C7H8BrN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 92992-85-3.

To a mixture of 2-methylpiperazine-1-carboxylic acid tert-butyl ester (2 g),2-bromo-3,5-dimethylpyridine (1.95 g),tris(dibenzylideneacetone)dipalladium(0)(183 mg),rac-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (250 mg) and tert-butoxy sodium (1.3 g) was added toluene (33 mL) and the mixture was stirred with heating under reflux for 8 hr. The reaction mixture was cooled and filtered through celite. The filtrate was evaporated and the obtained residue was purified by column chromatography (hexane:ethyl acetate)to give 4-(3,5-dimethylpyridin-2-yl)-2-methylpiperazine-1-carboxylic acid tert-butyl ester (1.61 g). MS(ESI)m/z:206(M+H)+

According to the analysis of related databases, 92992-85-3, the application of this compound in the production field has become more and more popular.

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If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 92992-85-3, 2-Bromo-3,5-dimethylpyridine.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 92992-85-3, name is 2-Bromo-3,5-dimethylpyridine. A new synthetic method of this compound is introduced below., Recommanded Product: 92992-85-3

To 2-bromo-3,5-dimethylpyridine (1 g) were added 1-(tert-butoxycarbonyl)-3-aminoazetidine (1.11 g),tris(dibenzylideneacetone)dipalladium(0)(250 mg),2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (330 mg),sodium tert-butoxide (770 mg) and toluene (8 mL) and the mixture was stirred at 120c overnight. The reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure. The obtained residue was purified by NH column chromatography (hexane:ethyl acetate)to give the title compound (965 mg). MS(APCI)m/z:278(M+H)+

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 92992-85-3, 2-Bromo-3,5-dimethylpyridine.

Some scientific research about 2-Bromo-3,5-dimethylpyridine

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 92992-85-3, 2-Bromo-3,5-dimethylpyridine.

Electric Literature of 92992-85-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 92992-85-3, name is 2-Bromo-3,5-dimethylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

(i) 2-Bromo-3,5-dimethylpyridine (12.7 g) 1,3-diaminopropane (31 ml) and pyridine (7.5 ml) were heated together under reflux for 12 hr. Working up the reaction as in the method of Example 14(i) gave 2-(3-aminopropylamino)-3,5-dimethylpyridine as an oil (2.45 g) which was used without further purification.

Reference:
Patent; Smith Kline & French Laboratories Limited; US4548940; (1985); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The origin of a common compound about 2-Bromo-3,5-dimethylpyridine

According to the analysis of related databases, 92992-85-3, the application of this compound in the production field has become more and more popular.

Share a compound : 92992-85-3

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 92992-85-3, 2-Bromo-3,5-dimethylpyridine.

Some scientific research about 2-Bromo-3,5-dimethylpyridine

Reference:
Patent; Smith Kline & French Laboratories Limited; US4548940; (1985); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Extended knowledge of 2-Bromo-3,5-dimethylpyridine

Application of 92992-85-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 92992-85-3, name is 2-Bromo-3,5-dimethylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

Example 166 2-[2-(3,5-dimethylpyridin-2-yl)-5,8-dioxo-6-(propan-2-yl)-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidin-4-yl]-N-(5-fluoropyridin-2-yl)acetamide . A mixture of 2-bromo-3,5-dimethylpyridine (64 mg, 345 muetaetaomicronIota) and hexamethylditin (72 muIota, 350 muetaetaomicronIota) in 1,4-dioxane (3 ml) was degassed with a stream of nitrogen, then tetrakis(triphenylphosphine)palladium(0) (12 mg, 10.8 muetaetaomicronIota) was added. The reaction was subjected to microwave irradiation at 1 10 C for 2h. 2-[2-Bromo-5,8-dioxo-6-(propan-2-yl)-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidin-4-yl]-N-(5-fluoropyridin-2-yl)acetamide (100 mg, 216 muetaetaomicronIota) (example 75) was added, and the reaction irradiated at 1 10C for a further 2h. KF and celite (1 :1 mixture, 250 mg) were added, and the solution stirred for one hour, before being filtered, washing with ethyl acetate/methanol, and concentrated under reduced pressure. The crude mixture was taken up in toluene (3 ml), and degassed with a stream of N2 for 5mins. Tetrakis(triphenylphosphine)palladium(0) (12 mg, 10.8 muetaetaomicronIota) was added, and the reaction irradiated to 120C in the microwave for 1 h, the irradiation was then repeated until conversion was complete. KF and celite (1 :1 mixture, 250 mg) were added, and the solution stirred for one hour, before being filtered, washing with ethyl acetate/methanol, and concentrated under reduced pressure. The crude material was purified by preparative HPLC, then further purified by trituration from MeCN to afford 27.7 mg (26% yield) of the title compound as an off-white powder. 1H NMR (500 MHz, Chloroform-d) delta [ppm] 1.34 (d, 6H), 2.35 (s, 3H), 2.75 (s, 3H), 4.39 (s, 2H), 4.51 – 4.64 (m, 1H), 5.46 (s, 2H), 6.95 (s, 1H), 7.37 – 7.44 (m, 2H), 8.09 – 8.17 (m, 2H), 8.33 (s, 1H), 8.91 (s, 1H). LC-MS (Analytical Method F) Rt = 2.30 min; MS (ESIpos): m/z = 490 [M+H]+.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; SIEBENEICHER, Holger; BRAeUER, Nico; POOK, Elisabeth; ROTGERI, Andrea; NEUHAUS, Roland; FISCHER, Oliver, Martin; NAGEL, Jens; DAVENPORT, Adam, James; CARR, James, Lindsay; TOWNSEND, Robert, James; CONNELLY URSINYOVA, Nina; PARROTT, Shelley, Anne; (471 pag.)WO2019/81343; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Share a compound : 92992-85-3

At the same time, in my other blogs, there are other synthetic methods of this type of compound,92992-85-3, 2-Bromo-3,5-dimethylpyridine, and friends who are interested can also refer to it.

Electric Literature of 92992-85-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 92992-85-3, name is 2-Bromo-3,5-dimethylpyridine. A new synthetic method of this compound is introduced below.

To a mixture of (R)-2-methylpiperazine-1-carboxylic acid tert-butyl ester (1 g),2-bromo-3,5-dimethylpyridine (975 mg),tris(dibenzylideneacetone)dipalladium(O)(92 mg),rac-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (125 mg) and tert-butoxy sodium (650 mg) was added toluene (17 mL) and the mixture was stirred under microwave irradiation at 130c for 2 hr. The reaction mixture was purified by column chromatography (hexane:ethyl acetate)to give the title compound (220 mg). MS (ESI)m/z: 306(M+H)+

At the same time, in my other blogs, there are other synthetic methods of this type of compound,92992-85-3, 2-Bromo-3,5-dimethylpyridine, and friends who are interested can also refer to it.