Category: 92992-85-3

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.92992-85-3, name is 2-Bromo-3,5-dimethylpyridine, molecular formula is C7H8BrN, molecular weight is 186.0491, as common compound, the synthetic route is as follows.HPLC of Formula: C7H8BrN

[0085 -Step e: Preparation of 2′,5′-dichloro-3,5-dimethyl-2,4′-bipyridine [0086] To a solution of 2,5-dichloropyridin-4-ylboromc acid (7.56 g, 40 mmol), 2-bromo- 3,5- dimethylpyridine (5.62 g, 30 mol) in dioxane (60 mL) and H?0 (12 mL) were added Pd(dppf)CI2 (1.35 g, 1.7 mmol) and K :'( ) · 31 >( > (16.2 g, 60 mmol), the mixture was stirred at reflux under N2 atmosphere overnight. TLC showed the reaction was complete. After cooling to room temperature, the mixture was filtered. Water (50 mL) was then added to the filtrate. The mixture was extracted with dichloromethane (150 mL x 3). The combined organic layers were washed with brine (300 mL), dried over Na2S04, filtered and concentrated. The residue was purified by silica gel column chromatography (petroleum ether/EtOAc = 20:1 to 10:1) to give title compound (3.1 g, 41%) as a white solid. NMR (400MHz, CDCI3): delta 8.46 (s, 1 H), 8.37 (s, 1 H), 7.47 (s, 1 H), 7.33 (s, 1 H), 2.39 (s, 3H), 2.16 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,92992-85-3, 2-Bromo-3,5-dimethylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; ZHANG, Xiaohu; WO2014/113191; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 92992-85-3, name is 2-Bromo-3,5-dimethylpyridine. A new synthetic method of this compound is introduced below., Safety of 2-Bromo-3,5-dimethylpyridine

In a three-neck round-bottom flask were placed 2-bromo-3,5- dimethylpyridine (5.00 g, 26.87 mmol) and dry THF (40 mL) under N2 atmosphere. The solution was cooled down at -78C. nBuLi 2.5 M in hexanes (12.89 mL, 32.25 mmol) was added dropwise to the solution. The reaction mixture was stirred at -78C for 20 mm and 5-methylfuran-2-carbaldehyde (2.94 mL, 29.56 mmol) dissolved in dry THF (10 mL) was added dropwise to thesolution. The reaction mixture was stirred at -78C for 30 mm and then was slowly warmed to rt and the stirring was kept at this temperature overnight. The reaction was quenched with sat. NH4CI. The aqueous layer was extracted with EtOAc. The combined organic layers were dried over Mg504, filtered and the solution was concentrated to dryness. The crude material was purified by silica gel column chromatography eluting with a gradient of Hexanes/EtOAc from [96:4] to [90:10]. The product fractions were collected and evaporated under redcued pressure to afford (3,5-di methyl pyrid in-2-yl)(5-methylfu ran-2- yl)methanol Ex.87a (3.29 g, 56%) as orange oil. 1 H NMR (400 MHz, CDCI3, d in ppm): 2.13 (s, 3H), 2.24 (d, 3H, J=0.8Hz), 2.33 (s, 3H), 5.71 (s, 1H), 5.83-5.86

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 92992-85-3, 2-Bromo-3,5-dimethylpyridine.

Reference:
Patent; GENFIT; DELHOMEL, Jean-Francois; PERSPICACE, Enrico; MAJD, Zouher; PARROCHE, Peggy; WALCZAK, Robert; (284 pag.)WO2018/138362; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 92992-85-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 92992-85-3, name is 2-Bromo-3,5-dimethylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

Compound 11b was prepared from 2-bromo-3,5-dimethylpyridine (9b) and 10 in a manner similar to that described for compound 11a, with a yield of 68% as a brown syrup. 1H NMR(DMSO-d6) d 2.29 (s, 3H), 2.30 (s, 3H), 4.55 (d, 2H, J = 5.7 Hz),5.21 (t, 1H, J = 5.7 Hz), 7.38 (d, 2H, J = 8.3 Hz), 7.47 (d, 2H,J = 8.3 Hz), 7.52 (br s, 1H), 8.30 (br s, 1H); MS (ESI) m/z 214 [M+H]+.

According to the analysis of related databases, 92992-85-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Hamaguchi, Wataru; Masuda, Naoyuki; Miyamoto, Satoshi; Kikuchi, Shigetoshi; Narazaki, Fumie; Shiina, Yasuhiro; Seo, Ryushi; Amano, Yasushi; Mihara, Takuma; Moriguchi, Hiroyuki; Hattori, Kouji; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3351 – 3367;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem