Liu, Xinli; Li, Bingwen; Hua, Xiufang; Cui, Dongmei published the artcile< 1,2-Hydroboration of Pyridines by Organomagnesium>, Application of C7H7NO2, the main research area is pyridine regioselective hydroboration organomagnesium.
Hydroboration of pyridine derivatives at room temperature with earth-abundant and biocompatible magnesium catalysts ligated by phosphinimino amides is developed. Fine turnover frequency (TOF) and distinguished 1,2-regioselectivity have been achieved. The exclusive chemoselective carbonyl hydroboration happens with competitive TOF. A HBpin assisted mechanism is deduced by the reaction rate law, activation parameters, and kinetic isotope effect (KIE) in combination with DFT calculations To our knowledge, this is the first example of pyridine 1,2-dearomatization by Mg-based catalysts.
Organic Letters published new progress about Activation energy. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application of C7H7NO2.