Category: 93-60-7

Zhu, Guohua; Huang, Yang; Wang, Chun; Lu, Linxia; Sun, Tongming; Wang, Miao; Tang, Yanfeng; Shan, Doudou; Wen, Shuijin; Zhu, Jinli published the artcile< A novel coumarin-based fluorescence chemosensor for Al3+ and its application in cell imaging>, Reference of 93-60-7, the main research area is coumarin fluorescence chemosensor aluminum cell imaging; Al(3+); Chemosensor; Coumarin; Live cells.

As an efficient turn-on fluorescent chemosensor for Al3+, a new coumarin derivative (CND) has been designed and synthesized by the condensation of 8-formyl-7-hydroxycoumarin with niacin hydrazide. The spectroscopic studies revealed that the sensor CND exhibited a remarkable fluorescence enhancement towards Al3+ with high selectivity and sensitivity in EtOH-HEPES (95:5, volume/volume, pH = 7.40), which was attributed to the photoinduced electron transfer (PET) and -C:N isomerization mechanism. Fluorescence titration calculations data showed that the detection limit and the association constants of CND for Al3+ are 2.51 × 10-7 M and 9.64 × 104 M-1, resp. The results of experiments, including Job’s plot, 1H NMR titration and ESI-MS, revealed that the stoichiometric binding between CND and Al3+ was 1:1. The studies of the pH dependency of CND for Al3+ detection, and the cell imaging suggested the sensor CND could be promisingly applied for the recognition of Al3+ in biol. cells.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Fluorescence. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Reference of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oates, Conor L.; Widegren, Magnus B.; Clarke, Matthew L. published the artcile< Manganese-catalysed transfer hydrogenation of esters>, Application In Synthesis of 93-60-7, the main research area is primary alc preparation manganese catalyst; ester reduction ethanol hydrogen transfer agent.

Manganese catalyzed ester reduction using ethanol as a hydrogen transfer agent in place of dihydrogen is reported. High yields can be achieved for a range of substrates using 1 mol% of a Mn(I) catalyst, with an alkoxide promoter. The catalyst is derived from a tridentate P,N,N ligand.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aliphatic esters Role: RCT (Reactant), RACT (Reactant or Reagent). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application In Synthesis of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guo, Yu; Wang, Ruo-Ya; Kang, Jia-Xin; Ma, Yan-Na; Xu, Cong-Qiao; Li, Jun; Chen, Xuenian published the artcile< Efficient synthesis of primary and secondary amides via reacting esters with alkali metal amidoboranes>, Formula: C7H7NO2, the main research area is primary secondary amide preparation chemoselective; ester sodium amidoborane amidation.

Authors report here a facile synthesis method of primary and secondary amides through a direct amidation of esters with sodium amidoboranes (NaNHRBH3, R = H, Me), at room temperature without using catalysts and other reagents. This process is rapid and chemoselective, and features quant. conversion and wide applicability for esters tolerating different functional groups. The exptl. and theor. studies reveal a reaction mechanism with nucleophilic addition followed by a swift proton transfer-induced elimination reaction.

Nature Communications published new progress about Amidation. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Formula: C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Frost, Scott C.; Walker, Paige; Orians, Colin M.; Robbat, Albert Jr. published the artcile< The Chemistry of Green and Roasted Coffee by Selectable 1D/2D Gas Chromatography Mass Spectrometry with Spectral Deconvolution>, Reference of 93-60-7, the main research area is roasted coffee spectral deconvolution gas chromatog mass spectrometry; 2D–GC/MS; GC/MS; coffee; coffee quality; deconvolution; green coffee.

Gas chromatog./mass spectrometry (GC/MS) is a long-standing technique for the anal. of volatile organic compounds (VOCs). When coupled with the Ion Analytics software, GC/MS provides unmatched selectivity in the anal. of complex mixtures and it reduces the reliance on high-resolution chromatog. to obtain clean mass spectra. Here, we present an application of spectral deconvolution, with mass spectral subtraction, to identify a wide array of VOCs in green and roasted coffees. Automated sequential, two-dimensional GC-GC/MS of a roasted coffee sample produced the retention index and spectrum of 750 compounds These initial analytes served as targets for subsequent coffee anal. by GC/MS. The workflow resulted in the quantitation of 511 compounds detected in two different green and roasted coffees. Of these, over 100 compounds serve as candidate differentiators of coffee quality, AAA vs. AA, as designated by the Coopedota cooperative in Costa Rica. Of these, 72 compounds survive the roasting process and can be used to discriminate green coffee quality after roasting.

Molecules published new progress about Gas chromatography. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Reference of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kasting, Gerald B.; Miller, Matthew A.; Xu, Lijing; Yu, Fang; Jaworska, Joanna published the artcile< In Vitro Human Skin Absorption of Solvent-deposited Solids: Niacinamide and Methyl Nicotinate>, Application of C7H7NO2, the main research area is niacinamide methyl nicotinate skin absorption; Absorption; Disposition; Passive diffusion/transport; Percutaneous; Permeability; Skin; Transdermal; pathways.

A quant. understanding of the dose dependence of topical delivery is important to cosmetic and dermatol. product development and to risk assessment for hazardous chems. contacting the skin. Despite considerable research, predictive capability in this area remains limited. To this end we conducted an exptl. skin absorption study of two closely related skin care agents, niacinamide (nicotinamide, NA) and Me nicotinate (MN), and analyzed the results quant. using a transient diffusion model described sep. (Yu et al. submitted for publication). Radiolabeled test compounds were solvent-deposited onto ex vivo human skin mounted in Franz diffusion cells over a dose range exceeding 4.5 orders of magnitude, and permeation was measured over a 1-4 day period. At low doses, the permeation rate of NA was approx. 60-fold lower than that of its lower melting, more lipophilic analog, MN; at high doses an even greater difference was observed The difference can be qual. explained based on higher lipid solubility and lower crystallinity of MN relative to NA. Dissolution-limited mass transfer through a lipid layer at the SC surface is suggested. Relevance of the results to practical skin care formulations was confirmed by a parallel study of NA in an o/w emulsion.

Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about Crystallinity. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application of C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hao, Pengfei; Guo, Chunyu; Wang, Meidan; Shen, Junju; Fu, Yunlong published the artcile< Lattice Water Controlled Photo- and Thermochromism of N-Protonated Carbomethoxypyridinium Iodoargentate Hybrids>, Quality Control of 93-60-7, the main research area is lattice water controlled photochromism thermochromism protonated carbomethoxypyridinium iodoargentate hybrid; silver iodide protonated carbomethoxypyridinium preparation crystal structure; thermochromism hydration dehydration induced protonated carbomethoxypyridinium iodoargentate; photochromism intermol charge transfer protonated carbomethoxypyridinium iodoargentate.

Two iodoargentate hybrids, {[HNOM][AgI2]·H2O} (1) and {[HINOM][AgI2]·H2O} (2) (HNOM+ = N-protonated 3-carbomethoxypyridinium; HINOM+ = N-protonated 4-carbomethoxypyridinium), were designed and prepared, which were constructed from typical [AgI2]- inorganic chains and cationic H-bonding supramol. networks (1-dimensional for 1 and three-dimensional for 2) of lattice H2O and positional isomeric N-protonated carbomethoxypyridinium. Two hybrids exhibit sensitive photochromism based on intermol. electron transfer (ET) and thermochromism due to reversible hydration and dehydration and the consequent variation of intermol. charge transfer (CT). Also, loss of lattice H2O gives rise to improved photochromic dehydrated form 1T and optically inert dehydrated form 2T, suggesting a delicate modulating effect of lattice contraction on the intermol. CT and ET as well as consequently photoresponsive behaviors.

Inorganic Chemistry published new progress about Charge transfer interaction (hydration/dehydration induced). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Quality Control of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.93-60-7, name is Methyl nicotinate, molecular formula is C7H7NO2, molecular weight is 137.136, as common compound, the synthetic route is as follows.Application In Synthesis of Methyl nicotinate

A 10 l Buechi stirred autoclave with gas inlet tube, stirrer, internal thermometer and pressure equalizer was initially charged with 1.72 kg of methyl nicotinate (12.5 mol). 3.68 kg of diethylamine (50 mol) and 100 g of potassium tert-butoxide as a catalyst were slowly added thereto, and the mixture was homogenized while stirring.The reaction mixture thus obtained was pumped through the reaction tube continuously at 4 l/h at a working pressure of 30 bar and exposed to a microwave power of 2.8 kW, 91% of which was absorbed by the reaction mixture. The residence time of the reaction mixture in the irradiation zone was approx. 42 seconds. At the end of the reaction tube, the reaction mixture had a temperature of 285 C. Immediately after leaving the reactor, the reaction mixture was cooled to room temperature with a jacketed coil heat exchanger.A conversion of 85% of theory was attained. The reaction product was pale yellowish in color; the iron content was <5 ppm. After distillative removal of the methanol formed and of the excess or unconverted reactants, 1.85 kg of N,N-diethylnicotinamide with a purity of 98% were obtained by means of vacuum distillation. At the same time, in my other blogs, there are other synthetic methods of this type of compound,93-60-7, Methyl nicotinate, and friends who are interested can also refer to it. Reference:
Patent; CLARIANT FINANCE (BVI) LIMITED; US2012/95238; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 93-60-7, Methyl nicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H7NO2, blongs to pyridine-derivatives compound. Computed Properties of C7H7NO2

To a stined solution of methyl nicotinate (500gm) in isopropyl alcohol was addedhydrazine hydrate (80%) (460m1). Resultant mixture was heated and stined at 80-85C for 4hrs. Reaction mixture was cooled to RT. Separated solid was filtered, washed with isopropyl alcohol and dried to give title compound as off white solid.?H NMR (DMSO-d6, 400 MHz, ppm): 9.967(1H, singlet), 8.967-8.961(1H, singlet), 8.699- 8.683(1H, doublet), 8.167-8.138(1H, doublet), 7.512-7.479(1H, triplet), 4.567(2H, Singlet) Mass (mlz):138 (M + 1)

The synthetic route of 93-60-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TORRENT PHARMACEUTICALS LIMITED; DUTT, Chaitanya; GUPTA, Rameshchandra; PATEL, Manish; ABRAHAM, Jaya; MISHRA, Vivek; KESARWANI, Amit; DESHPANDE, Shailesh; ZAMBAD, Shital, Kumar; MATHUR, Anoop; KOTECHA, Jignesh; LATAD, Sachin; CHAUDHARI, Anita; (45 pag.)WO2016/162785; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 93-60-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 93-60-7, name is Methyl nicotinate. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Lanthanum nitrate hexahydrate (La (NO 3) 3 .6H 2 0, 17.3 mg, 0.04 mmol) and nitrous oxide were added to a Soxhlet reflux vessel containing absorbent cotton and 2.0 g of dried pelletized molecular sieves 5 A (MS 5 A) , Tri-n-octylphosphine (90% purity, 40 muL, 0.08 mmol) and dimethyl carbonate dehydrated by distillation (8 mL) were placed and stirred at room temperature for 1 to 2 minutes. The resulting mixture was heated under heating reflux conditions (bath temperature of 110 C.) for 1 hour. The mixed solution was cooled to room temperature, the solvent component was distilled off under reduced pressure, and the mixture was dried at room temperature under 5 Torr or less for 1 hour to prepare a catalyst. In the reaction vessel, n-hexane (8 mL) as a solvent, 4-nitrobenzoic acid ester (4.0 mmol) as a carboxylic acid ester and benzyl alcohol (4.0 mmol) as a primary alcohol were added in this order. Immediately, the reactor was heated to reflux condition (bath temperature: 90 C.). Refluxing was continued while appropriately checking the progress of the reaction by TLC, and after 5 hours, the completion of the reaction was confirmed by TLC. Thereafter, the reaction mixture was cooled to room temperature, a small amount of water (0.3 to 0.5 mL) was added, and the reaction was stopped by stirring at room temperature for 5 minutes. The reaction mixture was dried over magnesium sulfate, filtered, and the filtrate was concentrated. The product was isolated from the concentrate by silica gel column chromatography (n-hexane: ethyl acetate). The yield was 99%.In Examples 25 to 29 and Comparative Examples 10 to 14, a product was obtained in the same manner as in Example 24, except that the compound shown in Table 4 was used as the carboxylic acid ester and the reaction time was changed. In addition, in Example 30 and Comparative Example 15, production was carried out in the same manner as in Example 24, except that methyl benzoate was used as the carboxylic acid ester, cyclohexanol as the secondary alcohol was used as the alcohol compound, and the reaction time was changed I got things. However, in Examples 26, 27 and 29 and Comparative Examples 11, 12 and 15, as shown in Table 4, the amounts of lanthanum compounds and ligands used were increased. The results are shown in Table 4 including the results of Example 24 and Comparative Example 9.

According to the analysis of related databases, 93-60-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NAGOYA UNIVERSITY; MITSUBISHI RAYON COMPANY LIMITED; SHIHARA, KAZUAKI; HATANO, MANABU; (25 pag.)JP5804472; (2015); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In an article, author is Wang, Jin, once mentioned the application of 93-60-7, Name is Methyl nicotinate, molecular formula is C7H7NO2, molecular weight is 137.136, MDL number is MFCD00006388, category is pyridine-derivatives. Now introduce a scientific discovery about this category, Quality Control of Methyl nicotinate.

One-pot synthesis of imidazo[1,2-alpha]pyridine thioethers using imidazo[1,2-alpha]pyridines, arylsulfonyl chlorides and hydrazine

A one-pot reaction of making RS-substituted imidazo[1,2-alpha]pyridine derivatives by directly using aryl or alkylsulfonyl chloride and hydrazine was developed, selectively giving good yields of the expected products. Compared with previously reported methods of using ArSO2NHNH2 as a sulfur source, this method is much cheaper, more practical and convenient and enriches current methods to make thioether-containing compounds, providing a good example of green chemistry.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 93-60-7, Quality Control of Methyl nicotinate.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem