Category: 93-60-7

Zhang, Xue; Wang, Yun; Li, Xiaoqing; Dai, Yejia; Wang, Qinghao; Wang, Guoyou; Liu, Depeng; Gu, Xuezhu; Yu, Dingrong; Ma, Yinlian; Zhang, Cun published the artcile< Treatment mechanism of Gardeniae fructus and its carbonized product against ethanol-induced gastric lesions in rats>, Reference of 93-60-7, the main research area is Gardeniae gastric lesions gastroprotective; Gardeniae Fructus; carbonized Gardeniae Fructus; ethanol-induced gastric lesion; gastroprotective; metabolomics; processed.

Gardeniae Fructus (GF) and carbonized GF (GFC) have been shown to exert a gastrointestinal protective effect and are frequently used in clin. practice for the treatment of hemorrhage and brown stool. In this study, we employed a combination of pharmacol. methods and metabolomics in a rat model of ethanol-induced acute stomach ulcer to investigate the gastroprotective effect of GF and GFC water extracts and the potential mechanism involved in this process. The levels of nitric oxide (NO) and interleukin 6 (IL-6) in the plasma of rats were determined The results showed that both GF and GFC reduced the ethanol-induced gastric lesions and expression of NO and IL-6 in these rats. Of note, 16 and 11 feature metabolites were filtered and identified in the GF and GFC groups, resp. Both GF and GFC act by restoring the biosynthesis of valine, leucine, and isoleucine, and the metabolism of glycerophospholipids. Moreover, histol. evaluation revealed that heat processing of GF to create GFC enhanced the gastric mucosa protective effect. Furthermore, heat processing converted the main pathway from alanine, aspartate, and glutamate metabolism, associated with GF, to histidine metabolism, associated with GFC. GF and GFC ameliorated gastric mucosa lesions in rats via reductions in NO production and inflammatory cytokine secretion, and the induction of prostaglandin E2.

Frontiers in Pharmacology published new progress about Biomarkers. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Reference of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Haemmerle, Michael; Le, Minh Hien; Hekmat, Omid published the artcile< GC-FID-based quantification of the sum of the three forms of vitamin B3 from animal liver>, Reference of 93-60-7, the main research area is gas chromatog flame ionization detector vitamin B3 liver; Flame ionization detection; Gas chromatography; Nicotinamide; Nicotinamide adenine dinucleotide; Nicotinic acid; Vitamin B(3).

Vitamin B3 (nicotinic acid, nicotinamide) is an essential water-soluble vitamin and cellular energy metabolism depends on the vitamin B3-derived cofactors. Inaccessible covalently-linked nicotinic acid in food such as maize can cause vitamin B3 deficiency in animals since maize is also deficient in tryptophan, the precursor of nicotinic acid. A sensitive and reproducible GC-FID-based method for the quantification of the sum of the three forms of vitamin B3 from animal liver was developed. Free nicotinic acid, free nicotinamide and nicotinamide moiety of NAD+/NADP+ (and their riboside precursors) were simultaneously derivatized as Me nicotinate. Reaction time and temperature and the extraction procedure for Me nicotinate were optimized. Starting from wild boar liver, removal of proteins, solvent exchange, derivatization, and chloroform extraction resulted in sufficient enrichment and baseline separation of Me nicotinate. The within-laboratory reproducibility of the full procedure was determined with relative standard deviation <10%. On-column limit of detection and lower limit of quantification for Me nicotinate were both sub-picomole. The accuracy of the method was determined from the recoveries of the pre-extraction spiked-in vitamin B3 standards The overall recovery for the full procedure was 16% but very consistent (relative standard deviation = 7%), enabling determination of apparent vitamin B3 concentrations for relative quant. comparison. Analytical Biochemistry published new progress about Esterification (methyl-). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Reference of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Xin-Yue; Zhang, Ming; Liu, Zhong; He, Jia-Hao; Wang, Xiao-Chen published the artcile< C3-Selective Trifluoromethylthiolation and Difluoromethylthiolation of Pyridines and Pyridine Drugs via Dihydropyridine Intermediates>, Related Products of 93-60-7, the main research area is trifluoromethylthiopyridine preparation one pot regioselective; pyridine trifluoromethylthiolation difluoromethylthiolation hydroboration oxidative aromatization; difluoromethylthiopyridine preparation regioselective one pot.

Herein, authors report a method for unprecedented C3-selective C-H tri- and difluoromethylthiolation of pyridines. The method relies on borane-catalyzed pyridine hydroboration for generation of nucleophilic dihydropyridines; these intermediates react with trifluoromethylthio and difluoromethylthio electrophiles to form functionalized dihydropyridines, which then undergo oxidative aromatization. The method can be used for late-stage functionalization of pyridine drugs for the generation of new drug candidates.

Journal of the American Chemical Society published new progress about Aromatization. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Related Products of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Proctor, Rupert S. J.; Chuentragool, Padon; Colgan, Avene C.; Phipps, Robert J. published the artcile< Hydrogen Atom Transfer-Driven Enantioselective Minisci Reaction of Amides>, Quality Control of 93-60-7, the main research area is amide heteroarene chiral phosphoric acid diacetyl light Minisci reaction; heteroarenyl alkyl amide stereoselective preparation.

Minisci-type reactions constitute one of the most powerful methods for building up complexity around basic heteroarenes. The most desirable variants involve formal oxidative coupling of a C-H bond on each partner, leading back to the simplest possible starting materials. We herein disclose a method that enables such a coupling of linear amides and heteroarenes with full control of enantioselectivity at the newly formed stereocenter as well as site selectivity on both the heteroarene and the amide. This is achieved by the use of a chiral phosphoric acid catalyst in conjunction with diacetyl as a combined hydrogen atom transfer reagent and oxidant. Diacetyl is directly photoexcitable, and thus, no extraneous photocatalyst is required: an added feature that contributes to the simplicity and practicality of the protocol.

Journal of the American Chemical Society published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Quality Control of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nallagonda, Rajender; Karimov, Rashad R. published the artcile< Copper-Catalyzed Regio- and Diastereoselective Additions of Boron-Stabilized Carbanions to Heteroarenium Salts: Synthesis of Azaheterocycles Containing Contiguous Stereocenters>, Recommanded Product: 3-(Methoxycarbonyl)pyridine, the main research area is nonaromatic nitrogen heterocycle preparation diastereoselective addition boron carbanion heteroarenium.

Nucleophilic addition of diborylalkyl reagents to N-alkyl or N-acylpyridinium and related heteroarenium salts has been developed as a key step for the synthesis of nonaromatic nitrogen heterocycles that contain contiguous stereogenic centers. Derivatization of the dihydropyridine products for the synthesis of tetrahydropyridines and piperidines have also been described.

ACS Catalysis published new progress about Boranes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (alkyl). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Recommanded Product: 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Changjian; Sun, Rong; Zhang, Yuting; Xiong, Biao; Dai, Hui; Dai, Yong published the artcile< Co-N-Si/AC Catalyst for Aerobic Oxidation of Benzyl Alcohols to Esters under Mild Conditions>, Reference of 93-60-7, the main research area is ester preparation green chem; benzyl alc aerobic oxidative esterification cobalt catalyst; aerobic oxidation; benzyl alcohols; heterogeneous cobalt.

A stable, earth-abundant, reusable cobalt-based heterogeneous catalyst is developed for the oxidative esterification of alcs. RCH2OH (R = Ph, naphthalen-1-yl, thiophen-2-yl, etc.) under ambient conditions, featuring broad substrate scope, providing good to excellent product yields. This protocol enables easy recyclability of the catalyst, measured up to five times without significant loss of efficiency. The active sites of Co-N-Si/AC are proposed to be Co-N species.

Molecules published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Reference of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shao, Zhihui; Zhong, Rui; Ferraccioli, Raffaella; Li, Yibiao; Liu, Qiang published the artcile< General and Phosphine-Free Cobalt-Catalyzed Hydrogenation of Esters to Alcohols>, Application In Synthesis of 93-60-7, the main research area is ester cobalt catalyst hydrogenation; lactone cobalt catalyst hydrogenation; alc preparation.

The first non-noble metal catalytic system that enabled an efficient hydrogenation of non-activated esters to alcs. in the absence of phosphine ligands (with a maximum turnover number of 2391) was described. The general applicability of this protocol was demonstrated by the high-yielding hydrogenation of 39 ester substrates including aromatic/aliphatic esters, lactones, polyesters and various pharmaceutical mols.

Chinese Journal of Chemistry published new progress about Alcohols Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application In Synthesis of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mora Vargas, Jorge Andres; Ortega, Julieth Orduna; Correia dos Santos, Maite Bernardo; Metzker, Gustavo; Gomes, Eleni; Boscolo, Mauricio published the artcile< A new synthetic methodology for pyridinic sucrose esters and their antibacterial effects against Gram-positive and Gram-negative strains>, Synthetic Route of 93-60-7, the main research area is sucrose pyridinic monoester antibacterial effect gram pos neg bacteria; Acoustic cavitation; Antibacterial activity; Homogeneous catalysis; Pyridinic methyl esters; ucrose esters.

Described are the development of a new synthetic method using ultrasonic irradiation and Na methoxide as catalyst for pyridinic sucrose esters (py-SEs), derived from transesterification of sucrose with picolinic, nicotinic and isonicotinic Me esters. The reaction was optimized using a 32 x 2 exptl. design, the reaction time, temperature and sucrose:Me ester molar ratio being evaluated. The method proved to be efficient for obtaining monosubstituted esters (≥83%) with high Me ester consumption (≥79%). The monosubstituted py-SEs were isolated by semipreparative HPLC, characterized by high-resolution mass spectrometry, calorimetry, vibrational spectroscopy, and 1H and 13C NMR. The py-SEs were tested against E. coli, S. aureus, and P. aeruginosa bacteria with min. inhibitory concentration values equal or inferior to the reference drugs for both E. coli and P. aeruginosa.

Carbohydrate Research published new progress about Antibacterial agents. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Synthetic Route of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rechitskaya, E. D.; Kuratieva, N. V.; Lider, E. V.; Eremina, J. A.; Klyushova, L. S.; Eltsov, I. V.; Kostin, G. A. published the artcile< Tuning of cytotoxic activity by bio-mimetic ligands in ruthenium nitrosyl complexes>, Application In Synthesis of 93-60-7, the main research area is ruthenium nitrosyl isonicotinate nicotinate complex preparation cytotoxic activity; crystal structure ruthenium nitrosyl isonicotinate nicotinate complex.

Three novel ruthenium nitrosyl complexes [Ru(NO)Cl3(InicMe)2] (1b), [RuNOCl3(NicEt)2] (1c) and [RuNOCl3(NicMe)2] (1d) (InicMe = Me isonicotinate, NicEt = Et nicotinate, NicMe = = Me nicotinate)were prepared and crystal structure of the complexes were determined by single crystal XRD anal. In all complexes, the organic ligands are coordinated by a pyridine nitrogen atom and located in trans-position each to other and in cis-position to NO group. In the crystal package of all compounds stacking interactions of two types were determined: πarene-πarene and πCOO-πarene stacking. Finally, cytotoxicity of the compounds was tested on Hep2 and HepG2 cell lines. In the set of similar compounds mer-[RuNO(L)2Cl3] (L = Py, γ-Pic, β-Pic, Inic-Alk, Nic-Alk), complexes with iso-nicotinic acid esters are the most toxic, while nicotinic acid derivatives are less toxic and compared with pyridine complex.

Journal of Molecular Structure published new progress about Antitumor agents. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application In Synthesis of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pitre, Spencer P.; Muuronen, Mikko; Fishman, Dmitry A.; Overman, Larry E. published the artcile< Tertiary Alcohols as Radical Precursors for the Introduction of Tertiary Substituents into Heteroarenes>, Computed Properties of 93-60-7, the main research area is tertiary alkyl substituted heterocycle preparation; heterocycle tertiary alc oxalate radical alkylation photocatalyst.

Despite many recent advances in the radical alkylation of electron-deficient heteroarenes since the seminal reports by Minisci and co-workers, methods for the direct incorporation of tertiary alkyl substituents into nitrogen heteroarenes are limited. This report describes the use of tert-alkyl oxalate salts, derived from tertiary alcs., to introduce tertiary substituents into a variety of heterocyclic substrates. This reaction has reasonably broad scope, proceeds rapidly under mild conditions, and is initiated by either photochem. or thermal activation. Insights into the underlying mechanism of the higher yielding visible-light initiated process were obtained by flash photolysis studies, whereas computational studies provided insight into the reaction scope.

ACS Catalysis published new progress about Computational chemistry. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Computed Properties of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem