Category: 93-60-7

Gonzalez, Alexandre; Benfodda, Zohra; Benimelis, David; Fontaine, Jean-Xavier; Molinie, Roland; Meffre, Patrick published the artcile< Extraction and Identification of Volatile Organic Compounds in Scentless Flowers of 14 Tillandsia Species Using HS-SPME/GC-MS>, Electric Literature of 93-60-7, the main research area is Tillandsia volatile organic compound flower mass spectrometry; PCA analysis; Tillandsia; faint-scented flowers; gas chromatography-mass spectrometry (GC-MS); headspace solid phase microextraction (HS-SPME); heatmap; scentless flowers; volatile organic compounds (VOCs).

VOCs emitted by flowers play an important role in plant ecol. In the past few years, the Tillandsia genus has been scarcely studied according to the VOCs emitted by flowers. Hence, we decided to enlarge the VOCs composition study already undergone in our laboratory on fragrant 3 Tillandsia species to 12 unscented and 2 faint-scented Tillandsia species and hybrids. The headspace solid phase microextraction (HS-SPME) coupled with gas chromatog. combined with the mass spectrometry (GC-MS) method was used to explore the chem. diversity of the VOCs. This study allowed the identification of 65 VOCs among the 14 species and between 6 to 25 compounds were identified in each of the species. The aromatic profile of 10 of the species and hybrids are similar to each other′s and show 8 predominant compounds: benzaldehyde, benzacetaldehyde, hexanol, hexanal, heptanal, octanal, nonanal, and furan-2-pentyl. Some specific compounds are present only in some unique species such as trans-calamenene, α-muurolene, and α-guaiene trans-β-bergamotene. The two faint-scented species studied present an original aromatic profile with a high number of monoterpenes or phenylpropanoids/benzenoids. Our studies allow a better understanding of the ecol. role and function of these VOCs in the interactions between these plants with their environment.

Metabolites published new progress about Aliphatic alcohols Role: ANT (Analyte), BSU (Biological Study, Unclassified), PAC (Pharmacological Activity), THU (Therapeutic Use), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Electric Literature of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chhem-Kieth, Sorivan; Lametsch, Rene; Hansen, Erik Torngaard; Ruiz-Carrascal, Jorge published the artcile< Storage and thermal stability of novel heme-based pigments prepared from porcine hemoglobin>, Product Details of C7H7NO2, the main research area is porcine Hb heme pigment storage thermal stability.

The stability of novel meat pigments derived from heme-enriched extract obtained from porcine Hb was assessed. Four different ligands (sodium nitrite, 4-methylimidazole, Me nicotinate, and pyrazine) were used to produce spray-dried, microencapsulated heme-ligand complexes. The storage and thermal stabilities of the produced pigments were assessed, over a 6-mo storage period and across a temperature range of 25-75°C. Color measurements and evaluation were made on the dissolved pigments by UV-visible absorbance spectroscopy and CIELAB color space. All heme-ligand complexes exhibited a stable red color across the storage period, except for the heme-Me nicotinate adduct, which color faded to brown after 30 days of storage. For thermal stability, only the heme-4-methylimidazole complex did not retain its red color beyond 55°C. The redness of the heme-pyrazine complex showed improvement upon heating, which is proposed to be due to the degradation of polymeric heme-pyrazine structure formed during the ligation process. Due to the global effort to reduce nitrite addition in food product, there is an important interest to replace it in processed meat products, wholly or in part. Addnl., the perspective of optimizing the usage of an under-utilized blood fraction is attractive for the meat industry. The development of a heme pigment derived from porcine blood thus presents a good com. potential. Two important aspects of such product would be its stability upon storage, or during heat treatment to levels similar to what is used in processed, cooked meat products. This study presents the behavior for those two aspects of different heme-ligand complexes, and compares the results obtained with a heme pigment produced from the traditionally used nitrite.

Journal of Food Process Engineering published new progress about Blood. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Product Details of C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Knight, Brian J.; Tolchin, Zachary A.; Smith, Joel M. published the artcile< A predictive model for additions to N-alkyl pyridiniums>, Recommanded Product: 3-(Methoxycarbonyl)pyridine, the main research area is pyridine Grignard methyl triflate regioselective dearomative addition; dihydropyridine preparation.

Disclosed in this communication is a thorough study on the dearomative addition of organomagnesium nucleophiles to N-alkyl pyridinium electrophiles. The regiochem. outcomes have observable and predictable trends associated with the substituent patterns on the pyridinium electrophile. Often, the substituent effects can be either additive, giving high selectivities, or ablative, giving competing outcomes. Addnl., the nature of the organometallic nucleophilic component was also investigated for its role in the regioselective outcome. The effects of either reactive component are important to both the overall reactivity and site of nucleophilic addition The utility of these observed trends is demonstrated in a concise, dearomative synthesis of a tricyclic compound shown to have insecticidal activity.

Chemical Communications (Cambridge, United Kingdom) published new progress about Dearomatization. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Recommanded Product: 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ali, Hazim M. published the artcile< Simultaneous Determination of Methyl Nicotinate and Three Salicylic Acid Derivatives in Pain Relief Spray Using HPLC-DAD>, COA of Formula: C7H7NO2, the main research area is methyl nicotinate salicylic acid derivative pain relief spray HPLCDAD.

For the first time, the high-performance liquid chromatog.-diode array detector (HPLC-DAD) approach was operated for the simultaneous assessment of Me nicotinate (MN), Me salicylate (MS), Et salicylate (ES) and 2-hydroxyethyl salicylate (HES) in one pharmaceutical formulation. The limits of detection of MN, HES, MS and ES were found to be 0.0144, 0.0455, 0.0087 and 0.0061μg/mL. The recovery percentages and relative standard deviations ranged from 93.48 to 102.12% and 0.301 to 6.341% for all active ingredients. Accordingly, the previously described data demonstrate the sensitivity, accuracy and precision of the developed method. Therefore, the investigated approach was effectively applied for the simultaneous assessment of MN, HES, MS and ES in DEEP HEAT Spray.

Separations published new progress about Analgesics. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, COA of Formula: C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Sen; Sun, Ze-Ying; Zhu, Kongying; Zhao, Wentao; Tang, Xiangyang; Guo, Minjie; Wang, Guangwei published the artcile< Metal-Free Difunctionalization of Pyridines: Selective Construction of N-CF2H and N-CHO Dihydropyridines>, COA of Formula: C7H7NO2, the main research area is pyridine nitroalkane bromodifluoroacetate regioselective nucleophilic addition; nitroalkyl difluoromethyl dihydropyridine preparation; nitromethylene difluoromethyl dihydropyridine preparation; formyl difluoromethyl dihydropyridine preparation.

A novel nucleophilic addition of N-difluoromethylpyridinium salts with nitroalkanes to synthesize N-CF2H-dihydropyridines and N-CHO-dihydropyridines in a highly efficient and regioselective pathway was reported. This protocol exhibited good functional group tolerance and good to excellent yields.

Organic Letters published new progress about Alkanes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, COA of Formula: C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Parrot, Isabelle; Bisi, Helene; Folliard, Arnaud; Bonnard, Michel published the artcile< Volatile Compounds from Flowers of Elaeagnus x submacrophylla Servett.: Extraction, Identification of Flavonoids, and Antioxidant Capacity>, Product Details of C7H7NO2, the main research area is Elaeagnus submacrophylla flavonoid volatile compound extraction antioxidant capacity; Elaeagnus submacrophylla; antioxidants; flavonoids; phenolic content; volatile compounds.

Beneficial to the ecosystem and with significant potential in permaculture, Elaeagnus x submacrophylla Servett. was studied here mainly for the identification of its floral odorants. After olfactory evaluation and determination of the volatile profile of freshly picked flowers by headspace/solid phase microextraction coupled with gas chromatog./mass spectrometry, an ethanolic extract was prepared and investigated for its antioxidant capacity. Unusual mols. were identified in the floral headspace, such as isochavicol or chrysanthemum acetate. The evaluation of the in vitro free radical scavenging capacity (from 0.4 to 1.3 mmol TE/g) and total phenolic content (65.1 mg GAE/g) of the extract pointed out a promising antioxidant activity, potentially related to the identification of several flavonoid glycosides. These results have to be considered in the context of the ever-increasing need to produce innovative natural extracts with notably interesting claims for the cosmetic field.

ChemPlusChem published new progress about Alcohols Role: ANT (Analyte), FFD (Food or Feed Use), PAC (Pharmacological Activity), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Product Details of C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

An, Ju Hyeon; Kim, Kyu Dong; Lee, Jun Hee published the artcile< Highly Chemoselective Deoxygenation Of N-Heterocyclic N-Oxides Using Hantzsch Esters As Mild Reducing Agents>, Computed Properties of 93-60-7, the main research area is deoxygenated nitrogen heterocycle green preparation chemoselective; heterocycle nitrogen oxide deoxygenation Hantzsch ester metallaphotocatalyst.

A highly chemoselective room-temperature deoxygenation method applicable to various functionalized N-heterocyclic N-oxides via visible light-mediated metallaphotoredox catalysis using Hantzsch esters as the sole stoichiometric reductant to afford deoxygenated N-heterocycles I [R = 6-OMe, 6-Cl, 2-Ph, etc.], II [R1 = H, 5-Br; X = CH, N] and III [R2 = 3-Ph, 2,6-Cl2, pyridin-2-yl, etc.] were reported. Despite the feasibility of catalyst-free conditions, most of these deoxygenations could be completed within a few minutes using only a tiny amount of a catalyst. This technol. also allowed for multigram-scale reactions even with an extremely low catalyst loading of 0.01 mol %. The scope of this scalable and operationally convenient protocol encompassed a wide range of functional groups, such as amides, carbamates, esters, ketones, nitrile groups, nitro groups and halogens, which provided access to the corresponding compounds I, II and III in good to excellent yields (an average of an 86.8% yield for a total of 45 examples).

Journal of Organic Chemistry published new progress about Amine oxides Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (heteroarene). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Computed Properties of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Elawa, Sherif; Mirdell, Robin; Farnebo, Simon; Tesselaar, Erik published the artcile< Skin blood flow response to topically applied methyl nicotinate: Possible mechanisms.>, Synthetic Route of 93-60-7, the main research area is capillary capacity; laser speckle contrast imaging; methyl nicotinate; microcirculation; tissue viability.

BACKGROUND: Methyl nicotinate (MN) induces a local cutaneous erythema in the skin and may be valuable as a local provocation in the assessment of microcirculation and skin viability. The mechanisms through which MN mediates its vascular effect are not fully known. The aim of this study was to characterize the vasodilatory effects of topically applied MN and to study the involvement of nitric oxide (NO), local sensory nerves, and prostaglandin-mediated pathways. METHODS: MN was applied on the skin of healthy subjects in which NO-mediated (L-NMMA), nerve-mediated (lidocaine/prilocaine), and cyclooxygenase-mediated (NSAID) pathways were selectively inhibited. Microvascular responses in the skin were measured using laser speckle contrast imaging (LSCI). RESULTS: NSAID reduced the MN-induced perfusion increase with 82% (P < .01), whereas lidocaine/prilocaine reduced it with 32% (P < .01). L-NMMA did not affect the microvascular response to MN. CONCLUSION: The prostaglandin pathway and local sensory nerves are involved in the vasodilatory actions of MN in the skin. Skin research and technology : International Society for Skin Imaging (ISSI) published new progress about 93-60-7. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Synthetic Route of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shi, Yinyin; Wang, Yue; Huang, Zhefan; Zhang, Fangjun; Shao, Yinlin published the artcile< tBuOLi-Promoted Hydroboration of Esters and Epoxides>, Computed Properties of 93-60-7, the main research area is ester lactone epoxide hydroboration chemoselective lithium tertbutoxide catalyst; alc preparation.

Com. available and inexpensive lithium tert-butoxide (tBuOLi) acts as a good precatalyst for the hydroboration of esters, lactones, and epoxides using pinacolborane as a borylation agent. Functional groups such as cyano-, nitro-, amino-, vinyl, and alkynyl are unaffected under the presented hydroboration process, representing high chemoselectivity. This transformation has also been effectively applied to the synthesis of key intermediates of Erlotinib and Cinacalcet. Preliminary investigations of the mechanism show that the hydroboration proceeds through the in situ formed BH3 species.

ACS Omega published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Computed Properties of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bairagi, Pallab Kumar; Goyal, Arpit; Verma, Nishith published the artcile< Methyl nicotinate biomarker of tuberculosis voltammetrically detected on cobalt nanoparticle-dispersed reduced graphene oxide-based carbon film in blood>, Quality Control of 93-60-7, the main research area is methyl nicotinate biomarker graphene oxide carbon cobalt nanoparticle tuberculosis.

Me nicotinate (MN), a metabolite of Mycobacterium tuberculosis, is an important biomarker of tuberculosis (TB). An effective measurement of MN can provide an early detection of TB, before it becomes life threatening. In this study, a cobalt (Co) and reduced graphene oxide (rGO) dispersed N-doped phenolic polymer precursor-based carbon film is used as the biosensor electrode to detect and measure MN in human blood for the first time. The Co nanoparticles are successfully used as the nonbiol. recognition element of MN. Doping of the carbon film with N-heteroatom using melamine increases the film electro-conductivity Using differential pulse voltammetry, the sensor electrode exhibits excellent linearity (0.9925) over 0.05-14 mg L-1MN concentrations (S/N ratio = 3), with high sensitivity (1735.2μA mM-1 cm-2) and low detection limit (0.0004 mM). The sensor also shows good selectivity and high recovery for MN. Most importantly, the sensor successfully confirms its clin. applicability when tested in the synthetic clin. MN solutions (RSD < 6.5%). The method and materials developed in this study have paved a new platform for developing similar biosensors using non-biol. components for chronic diseases such as typhoid and kidney-dysfunction. Sensors and Actuators, B: Chemical published new progress about Blood. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Quality Control of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem