Category: 93-60-7

Arshad, Zarina; Saied, Sumayya; Ali, Basharat; Salar, Uzma; Tauseef, Saima; Arshia; Ajaz, Munazza; Khan, Uroosa; Haider, Syed Moazzam; Taha, Muhammad; Khan, Khalid Mohammed published the artcile< Synthesis of N'-nicotinoyl sulfonohydrazides and their antimicrobial activity>, Formula: C7H7NO2, the main research area is nicotinoyl sulfonohydrazide preparation antibacterial antifungal.

N’-Nicotinoyl sulfonohydrazide derivatives I [R = Me, Ph, 2-O2NC6H4, etc.] were synthesized from nicotinyl hydrazide and evaluated for their antimicrobial potential against Gram pos. bacterial strains (Bacillus cereus, Bacillus subtilis, Corynebacterium diphtheriae, Staphylococcus fecalis, Staphylococcus aureus and MRSA (Methicillin-resistant Staphylococcus aureus)) and Gram neg. bacterial strains (Escherichia.coli, Pseudomonas aeruginosa, Salmonella ParatyphiB, Salmonella tyhpi). Compound I [R = 2-OH-3,5-diClC6H2] showed outstanding antibacterial activity against Staphylococcus fecalis and compounds I [R = 2-O2NC6H4, 2-OH-3,5-diClC6H2] were found to be moderately activite against Salmonella Paratyphi B, shown by their zone of inhibition values. In addition to that compond I [R = Me] also showed moderate activity against Escherichia coli. All derivatives I were also subjected for the evaluation of their antifungal activity against Saccharomyces cerevisiae, Microsporum canin, Rhizopus, Aspergillus niger, Candida albicans and Candida tropicalis. Compound I [R = 2-OH-3,5-diClC6H2] showed promising antifungal activity against Rhizopus sp. and compounds I [R = Me, 2,4-di-MeOC6H3] showed moderate antifungal potential against Microsporum canis, Aspergillus niger and Candida tropicalis.

Journal of the Chemical Society of Pakistan published new progress about Antibacterial agents. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Formula: C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Dong; Jiang, Yuanyang; Dong, Linru; Li, Gaoyu; Sun, Baoying; Desaubry, Laurent; Yu, Peng published the artcile< One-Pot Selective Saturation and Functionalization of Heteroaromatics Leading to Dihydropyridines and Dihydroquinolines>, Related Products of 93-60-7, the main research area is pyridine one pot regioselective dearomatization bond formation; dihydropyridine preparation; quinoline one pot regioselective dearomatization bond formation; dihydroquinoline preparation.

A one-pot regioselective two C-C-bond-forming dearomatization of pyridines and quinolines is disclosed. Two 3,4-betaines are identified for the first time as very useful organic synthons in heterocyclic chem. Furthermore, the chem. reactivity of the prepared trifluoromethyl ketones, a new type of push-pull enones, has been explored to develop straightforward methods for their functionalization. This protocol represents a breakthrough in the dearomatization of heteroaromatics as both the selective saturation and functionalization of heteroaromatics are achieved in high efficiency by the attachment of two substituents, including the valuable trifluoromethyl ketone group.

Journal of Organic Chemistry published new progress about C-C bond formation. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Related Products of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hou, Xiaoya; Zhou, Sen; Li, Yuli; Guo, Minjie; Zhao, Wentao; Tang, Xiangyang; Wang, Guangwei published the artcile< Synthesis of Indolizines from Pyridinium Salts and Ethyl Bromodifluoroacetate>, COA of Formula: C7H7NO2, the main research area is indolizine synthesis annulation pyridinium salt bromodifluoroacetate.

Here we present a novel annulation of pyridinium salts with BrCF2CO2Et to access the indolizine derivatives with high efficiency. The α substitution of pyridine plays a key role in determining the reaction pathways. Various types of indolizines can be conveniently accessed from easily available pyridinium salts under mild and simple reaction conditions.

Organic Letters published new progress about Cyclization, regioselective. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, COA of Formula: C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pang, Maofu; Shi, Le-Le; Xie, Yufang; Geng, Tianyi; Liu, Lan; Liao, Rong-Zhen; Tung, Chen-Ho; Wang, Wenguang published the artcile< Cobalt-Catalyzed Selective Dearomatization of Pyridines to N-H 1,4-Dihydropyridines>, Computed Properties of 93-60-7, the main research area is pyridine cobalt catalyst chemoselective regioselective dearomatization; dihydropyridine preparation.

Catalytic reduction of pyridines to N-H 1,4-dihydropyridines was exceptionally challenging because they are essential intermediates to form tetrahydropyridines. Using a facile dihydrogen source H3N·BH3 to activate the pyridine ring in situ, was achieved by selective transfer hydrogenation of nicotinate derivatives to N-H 1,4-dihydropyridines by cobalt-amido cooperative catalysis. The reactions operated smoothly under mild conditions to produce a variety of N-H 1,4-dihydropyridines with high chemo- and regioselectivity. This catalytic method also provides a practical protocol to regenerate Hantzsch analogs after delivery of H2.

ACS Catalysis published new progress about Chemoselectivity. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Computed Properties of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ismael, Aya; Gevorgyan, Ashot; Skrydstrup, Troels; Bayer, Annette published the artcile< Renewable Solvents for Palladium-Catalyzed Carbonylation Reactions>, Related Products of 93-60-7, the main research area is aryl bromide boronic acid palladium renewable solvent carbonylative coupling; ketone aryl preparation; amine aryl bromide palladium renewable solvent aminocarbonylation catalyst; amide preparation; alkoxide aryl bromide palladium renewable solvent alkoxycarbonylation catalyst; ester preparation.

Solvents constitute the largest component for many chem. processes and substitution of nonrenewable solvents is a longstanding goal for green chem. Here, we show that Pd-catalyzed carbonylative couplings, such as carbonylative cross-couplings, aminocarbonylations, and alkoxycarbonylations, can be successfully realized using renewable solvents. The present research covers not only well-established renewable solvents, such as 2-methyltetrahydrofuran (2MeTHF), limonene, and di-Me carbonate, but also recently introduced biomass-derived 1,1-diethoxyethane, isosorbide di-Me ether, eucalyptol, rose oxide, γ-terpinene, and α-pinene. The carbonylative coupling of boronic acids and aryl bromides works well in limonene. Aminocarbonylation gave excellent results in di-Me carbonate, α-pinene, and limonene, while alkoxycarbonylation was successful in 2MeTHF, α-pinene, γ-terpinene, and di-Me carbonate. The developed methods based on renewable solvents can be used for the synthesis of com. drug Trimetozine and an analog of Itopride.

Organic Process Research & Development published new progress about Alkoxycarbonylation. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Related Products of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kumari, Renu; Singh, R. T. published the artcile< Studies on the effect of dielectric constants of aquo-DMF solvent- system of the solvolysis products of nicotinates>, Reference of 93-60-7, the main research area is dimethyl formamide nicotinate solvolysis dielec constant.

From the enhancement observed in ΔG* values with simultaneous decrease in the values of ΔH and ΔS* of the reaction, it is concluded that the organic co-solvent DMF (DMF) acts as entropy controller and enthalpy stimulator solvent for alkali catalyzed solvolysis of Me nicotinate. Form the evaluated values of water mols. associated with the activated complex of the reaction which are found to increase with increase in the temperature of the reaction, it is inferred that the bimol. mechanistic path is changed to unimol. in presence of the organic component (DMF) of the reaction media. The numerical value of Iso-Kinetic temperature of the reaction which comes to be nearly 287.5 (below 300) indicates that there is weak but considerable solvent-solute interaction in the aquo-DMF solvent system.

Journal of Ultra Chemistry published new progress about Activation energy. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Reference of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Dong; Wang, Zhentao; Liu, Zhenlin; Huang, Mindong; Hu, Jianyong; Yu, Peng published the artcile< Strategic C-C Bond-Forming Dearomatization of Pyridines and Quinolines>, Recommanded Product: 3-(Methoxycarbonyl)pyridine, the main research area is regioselective diastereoselective tetrahydropyridine tetrahydroquinoline preparation one pot aromatization; dearomative double nucleophilic addition pyridine quinoline.

A one-pot protocol for the dearomative double nucleophilic addition to pyridines and quinolines, providing convenient, regioselective and diastereoselective access to tetrahydropyridines and tetrahydroquinolines under reductant-free conditions is described. This method also offers a new strategy for the general dearomatization of nitrogen heteroaromatics

Organic Letters published new progress about Crystal structure. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Recommanded Product: 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Zhong; He, Jia-Hao; Zhang, Ming; Shi, Zhu-Jun; Tang, Han; Zhou, Xin-Yue; Tian, Jun-Jie; Wang, Xiao-Chen published the artcile< Borane-Catalyzed C3-Alkylation of Pyridines with Imines, Aldehydes, or Ketones as Electrophiles>, Product Details of C7H7NO2, the main research area is C3 selective pyridine preparation regioselective; pyridine imine aldehyde ketone alkylation borane catalyst.

Achieving C3-selective pyridine functionalization is a longstanding challenge in organic chem. The existing methods, including electrophilic aromatic substitution and C-H activation, often require harsh reaction conditions and excess pyridine and generate multiple regioisomers. Herein, authors report a method for borane-catalyzed tandem reactions that result in exclusively C3-selective alkylation of pyridines. These tandem reactions consist of pyridine hydroboration, nucleophilic addition of the resulting dihydropyridine to an imine, an aldehyde, or a ketone, and subsequent oxidative aromatization. Because the pyridine is the limiting reactant and the reaction conditions are mild, this method constitutes a practical tool for late-stage functionalization of structurally complex pharmaceuticals bearing a pyridine moiety.

Journal of the American Chemical Society published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Product Details of C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Elif Ozturkkan Ozbek, Fureya; Ugurlu, Guventurk; Kalay, Erbay; Necefoglu, Hacali published the artcile< Synthesis, characterization and computational studies of 4-[(Pyridine-3-carbonyl)-hydrazonomethyl]-benzoic acid>, Reference of 93-60-7, the main research area is nicotinohydrazide mol structure hyperpolarizability dipole moment UV NMR IR.

A new hydrazone derivative compound, 4-[(Pyridine-3-carbonyl)-hydrazonomethyl]-benzoic acid, C15H11N3O, was obtained and characterized by 1H NMR, 13C NMR and UV-Vis, FT-IR and FT-Raman spectroscopy techniques. Mol. geometry, vibrational wavenumbers, frontier MO and non-linear optical (NLO) property of the title compound were calculated using ab initio Hartree-Fock (HF) and D. Functional Theory (DFT), employing B3LYP functional at 6-311++G (d,p) basis set. 1H and 13C NMR chem. shifts were calculated by using the gauge in dependent AO (GIAO) method at the HF and B3LYP methods with different basis sets. In addition, the HOMO and the LUMO were obtained from DFT LSDA methods with 6-311++G (d,p) basis set. The NLO behavior of the title compound has been studied by determining the elec. dipole moment (μ) and hyperpolarizability (β) using both B3LYP/6-311++G (d,p) and HF/6-311++G (d,p) methods. The energy gaps s(ΔEgap = ELUMO-EHOMO) of title mol. were calculated at 4.15, 2.77 and 9.81 eV with DFT-B3LYP/6-311++ G (d,p), DFT-LSDA/6-311++ G (d,p) and HF/6-311++ G (d,p) level of theory, resp. The calculated exptl. energy gap was found as 2.827 eV.

Journal of Molecular Structure published new progress about Conformational potential energy surface. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Reference of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cheung, Chi Wai; Shen, Ni; Wang, Shao-Peng; Ullah, Asim; Hu, Xile; Ma, Jun-An published the artcile< Manganese-mediated reductive amidation of esters with nitroarenes>, Electric Literature of 93-60-7, the main research area is aryl amide; ester nitroarene reductive amidation.

A convenient and efficient method to synthesize N-aryl amides RNHC(O)R1 (R = 4-methylphenyl, 2H-1,3-benzodioxol-5-yl, quinolin-6-yl, etc; R1 = n-C6H13, cyclohexyl, 4-chlorophenyl, pyridin-3-yl, etc.) via amidation of esters R1C(O)OR2 (R2 = Et, benzyl, 2H-1,3-benzodioxol-5-ylmethyl, etc.) with nitroarenes RNO2 was reported. In the presence of manganese metal, this amidation proceeded smoothly without the need for addnl. catalysts or ligands. Various esters and nitroarenes are suitable substrates to afford a wide range of N-aryl amides, including bio-active mols. RNHC(O)R1 (R = 2-phenyl-1,3-benzoxazol-5-yl, R1 = Ph; R = 2-phenyl-1,3-benzoxazol-5-yl, R1 = benzyl) and intermediates I (X = H, Cl) to drug mols. e.g., II.

Organic Chemistry Frontiers published new progress about Amidation (reductive). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Electric Literature of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem